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요한복음 2:4의 Γύναι 용법에 대한 유진 나이다의 견해
거트M.네퍼(Gert M. Knepper),김형동(번역자) 대한성서공회 2016 성경원문연구 Vol.- No.39
이 연구 논문은 요한복음 2:4에 있어서 γύναι의 용례에 대한 유진 나이다의 견해와 상응하는 논의들이 50여년 이상에 걸쳐 변화해 온 방식을 고찰한다. 그는 한편으로 지탱할 수 없는 그의 견해에 대한 점차적으로 더욱더 시시각각 변하는 논의들을 만들어 내었지만, 다른 한편으로는 서서히 이 특별한 호칭이 지닌 좀 더 부드러운 뜻을 선호하는 것 같다. 본 논문은 이 문제에 대한 최근의 견해들을 요약하고, γύναι의 번역에 대한 논평으로 마무리한다.
Transferrin ( Tf ) and Group - specific Component ( Gc ) Variants in Korean Population
( Moon You Oh,Friedrich Kneppers,Chung Choo Lee ) 한국유전학회 1985 Genes & Genomics Vol.7 No.2
Some avriants of Transferrin and Group-specific Component have been investigated in Korean population by polyacrylamide gel isoelectric focusing. Among 1,085 unrelated individuals, 4 heterozygous transferrin variants. C1B1, C2B1, C2B1-2 and C2-variant, were detected. The numbers of each variant were 5(C1B1), 1(C2B1), 1(C2B1-2), and 1(C2-variant), respectively. The gene frequencies of the variants were; B1=0.0028, B1-2=0.00046, unknown variant=0.00046, respectively. On the other hand, among 1,227 unrelated individuals, 6 kinds of variants of Group-specific Component were detected, and their numbers were 2(1F-1A8), 2(2-1A9), 2(2-1A8), 1(2-1A12), 1(1S-1A9), 1(1A5-1A8), respectively. All of the variants were heterozygous only.
Nielsen, Jakob,Kwon, Tae-Hwan,Frokiaer, Jorgen,Knepper, Mark A,Nielsen, Soren American Physiological Society 2007 American Journal of Physiology Vol.292 No.1
<P>Aldosterone induces redistribution of epithelial sodium channel (ENaC) to the apical plasma membrane from intracellular vesicles in renal connecting tubule (CNT) and cortical collecting duct (CCD). The role of the classical mineralocorticoid receptor (MR) in ENaC trafficking is still debated. We examined whether the MR antagonist spironolactone affects ENaC regulation in the kidney cortex of aldosterone-infused rats. Aldosterone infusion for 7 days resulted in a plasma aldosterone concentration in the high physiological range (3 to 4 nM). Aldosterone infusion decreased plasma K(+) concentration compared with untreated control rats. Cotreatment with spironolactone completely blocked the aldosterone-induced decrease in plasma K(+). Immunoblotting and immunohistochemistry showed increased protein abundance of Na-K-ATPase alpha(1)-subunit and NCC in the kidney cortex, in response to aldosterone infusion that was blocked by spironolactone. In contrast, aldosterone-induced redistribution of ENaC subunits from the cytoplasm to the apical plasma membrane domain in CNT and CCD was unaffected by spironolactone. Immunoblotting of alphaENaC showed increased protein abundance in aldosterone-infused rats that was not blocked by spironolactone treatment. To exclude possible glucocorticoid receptor (GR)-mediated effects of aldosterone, we treated aldosterone-infused rats with both spironolactone and the GR antagonist RU486. Combined MR and GR blockade prevented neither ENaC trafficking nor the upregulation of alphaENaC protein abundance in aldosterone-infused rats. We provide new evidence for ENaC trafficking occurring independent of MR and GR activation in aldosterone-infused rats.</P>
Hwang, Jacqueline R.,Chou, Chung-Lin,Medvar, Barbara,Knepper, Mark A.,Jung, Hyun Jun American Physiological Society 2017 American Journal of Physiology Vol.313 No.1
<P>The gene encoding the aquaporin-2 water channel is regulated transcriptionally in response to vasopressin. In the renal collecting duct, vasopressin stimulates the nuclear translocation and phosphorylation (at Ser<SUP>552</SUP>) of β-catenin, a multifunctional protein that acts as a transcriptional coregulator in the nucleus. The purpose of this study was to identify β-catenin-interacting proteins that might be involved in transcriptional regulation in rat inner medullary collecting duct (IMCD) cells, using experimental and computational approaches. We used a standard chromatin immunoprecipitation procedure coupled to mass spectrometry (ChIP-MS) in a nuclear fraction isolated from rat IMCD suspensions. Over four biological replicates, we reproducibly identified 43 β-catenin-binding proteins, including several known β-catenin-binding partners as well as novel interacting proteins. Multiple proteins involved in transcriptional regulation were identified (Taf1, Jup, Tdrd3, Cdh1, Cenpj, and several histones). Many of the identified β-catenin-binding partners were found in prior studies to translocate to the nucleus in response to vasopressin. There was only one DNA-binding transcription factor (TF), specifically Taf1, part of the RNA-polymerase II preinitiation complex. To identify sequence-specific TFs that might interact with β-catenin, Bayes’ theorem was used to integrate data from several information sources. The analysis identified several TFs with potential binding sites in the <I>Aqp2</I> gene promoter that could interact with β-catenin in the regulation of <I>Aqp2</I> gene transcription, specifically Jun, Junb, Jund, Atf1, Atf2, Mef2d, Usf1, Max, Pou2f1, and Rxra. The findings provide information necessary for modeling the transcriptional response to vasopressin.</P>
Altered Renal Sodium Transporter Expression in an Animal Model of Type 2 Diabetes Mellitus
Oh, Yun Kyu,Joo, Kwon Wook,Lee, Jay Wook,Jeon, Un Sil,Lim, Chun Soo,Han, Jin Suk,Knepper, Mark A.,Na, Ki Young The Korean Academy of Medical Sciences 2007 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.22 No.6
<P>Hemodynamic factors play an important role in the development and/or progression of diabetic nephropathy. We hypothesized that renal sodium transporter dysregulation might contribute to the hemodynamic alterations in diabetic nephropathy. Otsuka Long Evans Tokushima Fatty (OLETF) rats were used as an animal model for type 2 diabetes. Long Evans Tokushima (LETO) rats were used as controls. Renal sodium transporter regulation was investigated by semiquantitative immunoblotting and immunohistochemistry of the kidneys of 40-week-old animals. The mean serum glucose level in OLETF rats was increased to 235±25 mg/dL at 25 weeks, and the hyperglycemia continued up to the end of 40 weeks. Urine protein/creatinine ratios were 10 times higher in OLETF rats than in LETO rats. At 40th week, the abundance of the epithelial sodium channel (ENaC) β-subunit was increased in OLETF rats, but the abundance of the ENaC γ-subunit was decreased. No significant differences were observed in the ENaC α-subunit or other major sodium transporters. Immunohistochemistry for the ENaC β-subunit showed increased immunoreactivity in OLETF rats, whereas the ENaC γ-subunit showed reduced immunoreactivity in these rats. In OLETF rats, ENaC β-subunit upregulation and ENaC γ-subunit downregulation after the development of diabetic nephropathy may reflect an abnormal sodium balance.</P>