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Expression Profile of Neuro-Endocrine-Immune Network in Rats with Vascular Endothelial Dysfunction
Li, Lujin,Jia, Zhenghua,Xu, Ling,Wu, Yiling,Zheng, Qingshan The Korean Society of Pharmacology 2014 The Korean Journal of Physiology & Pharmacology Vol.18 No.2
This study was to determine the correlation between endothelial function and neuro-endocrine-immune (NEI) network through observing the changes of NEI network under the different endothelial dysfunction models. Three endothelial dysfunction models were established in male Wistar rats after exposure to homocysteine (Hcy), high fat diet (HFD) and Hcy+HFD. The results showed that there was endothelial dysfunction in all three models with varying degrees. However, the expression of NEI network was totally different. Interestingly, treatment with simvastatin was able to improve vascular endothelial function and restored the imbalance of the NEI network, observed in the Hcy+HFD group. The results indicated that NEI network may have a strong association with endothelial function, and this relationship can be used to distinguish different risk factors and evaluate drug effects.
Expression Profile of Neuro-Endocrine-Immune Network in Rats with Vascular Endothelial Dysfunction
Lujin Li,Yiling Wu,Qingshan Zheng,Zhenghua Jia,Ling Xu 대한약리학회 2014 The Korean Journal of Physiology & Pharmacology Vol.18 No.2
This study was to determine the correlation between endothelial function and neuro-endocrineimmune(NEI) network through observing the changes of NEI network under the different endothelialdysfunction models. Three endothelial dysfunction models were established in male Wistar rats afterexposure to homocysteine (Hcy), high fat diet (HFD) and Hcy+HFD. The results showed that therewas endothelial dysfunction in all three models with varying degrees. However, the expression of NEInetwork was totally different. Interestingly, treatment with simvastatin was able to improve vascularendothelial function and restored the imbalance of the NEI network, observed in the Hcy+HFD group. The results indicated that NEI network may have a strong association with endothelial function, andthis relationship can be used to distinguish different risk factors and evaluate drug effects.