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Outcomes of surgical management of buschke-lowenstein tumor in a Philippine tertiary hospital
Sofia Isabel T. Manlubatan,Mark Augustine S. Onglao,Mayou Martin T. Tampo,Marc Paul J. Lopez 대한대장항문학회 2022 Annals of Coloproctolgy Vol.38 No.1
Buschke-Lowenstein tumor (BLT) is a sexually transmitted infection (STI) caused by the human papillomavirus. This study investigated the profile, management, and outcomes of patients who underwent surgery for BLT from 2015 to 2019 at the Philippine General Hospital. Seven patients underwent surgery for BLT. All were male, with ages ranging from 21 to 41 years. Presenting symptoms were anal mass, foul-smelling discharge, pain, bleeding, and pruritus. All were positive for human immunodeficiency virus. All admitted to having engaged in both insertive and receptive anal intercourse, with multiple partners. All underwent excision with healing by secondary intention. Two had recurrence of warts. Four had an anal stricture. Of these, 3 underwent anal dilatation, while 1 had to undergo proximal bowel diversion. One had intraepithelial carcinoma without dermal invasion on histopathologic analysis. BLT is a rare STI characterized by local aggressiveness but with low malignant potential. Wide excision remains to be the mainstay of treatment.
Sofia Isabel T. Manlubatan,Marc Paul J. Lopez,Mark Augustine S. Onglao,Hermogenes J. Monroy III 대한대장항문학회 2021 Annals of Coloproctolgy Vol.37 No.4
Purpose: The coronavirus disease 2019 (COVID-19) pandemic has strained healthcare resources worldwide. Despite the high number of cases, cancer management should remain one of the priorities of healthcare, as any delay would potentially cause disease progression.Methods: This was an observational study that included nonmetastatic rectal cancer patients managed at the Philippine General Hospital from March 16 to May 31, 2020, coinciding with the lockdown. The treatment received and their outcomes were investigated.Results: Of the 52 patients included, the majority were female (57.7%), belonging to the age group of 50 to 69 years (53.8%), and residing outside the capital (59.6%). On follow-up, 23.1% had no disease progression, 17.3% had local progression, 28.8% had metastatic progression, 19.2% have died, and 11.5% were lost to follow up. The initial plan for 47.6% patients was changed. Of the 21 patients with nonmetastatic disease, 2 underwent outright resection. The remaining 19 required neoadjuvant therapy. Eight have completed their neoadjuvant treatment, 8 are undergoing treatment, 2 had their treatment interrupted, and 1 has yet to begin treatment. Among the 9 patients who completed neoadjuvant therapy, only 1 was able to undergo resection on time. The rest were delayed, with a median time of 4 months. One has repeatedly failed to arrive for her surgery due to public transport limitations. There was 1 adjuvant chemotherapy-related mortality.Conclusion: Delays in cancer management resulted in disease progression in several patients. Alternative neoadjuvant treatment options should be considered while taking into account oncologic outcomes, acceptable toxicity, and limitation of potential COVID-19 exposure.
Ernesto Barzola Navarro,Emilio Vicente Lopez,Yolanda Quijano,Riccardo Caruso,Valentina Ferri,Hipolito Durand,Isabel Fabra Cabrera,Eduardo Diaz Reques,Benedetto Ielpo,Anastasiia Yuriyivna Glagoliev,Car 한국간담췌외과학회 2019 Annals of hepato-biliary-pancreatic surgery Vol.23 No.2
BRCA gene mutations are found in up to 10% of pancreatic adenocarcinoma cases. We present a description of 4 cases along with a review of the current literature regarding pathogenesis, target treatment, response and survival rates in these types of malignancies. We describe four cases of pancreatic adenocarcinoma, in three of which the BRCA2 mutation was identified, in one - BRCA1 gene alteration. Two patients underwent surgery following the neoadjuvant treatment with Folfirinox and radiotherapy; in the first case, a distal pancreatectomy with splenectomy was performed and in the second one - the Whipple’s procedure. In both cases, a complete pathological response was reported. Other 2 patients were treated with Folfirinox after BRCA mutation identification and acceptable life expectancy was obtained. The association of pathologic complete response (PCR) with lower rates of local recurrence and better survival in patients with various types of adenocarcinomas is well known. Identification of such patients carrying BRCA mutations could provide an application of better personalized treatment. In some patients with pancreatic cancer, especially when there is clinical or demographic reason to suspect a genetic predisposition, a confirmation of the presence of BRCA mutations could provide an opportunity to use target treatment with beneficial outcomes regarding survival.
Characterization and Classification of Soils in Mexicali Valley, Baja California, Mexico
Monica Aviles-Marin,Roberto Soto-Ortiz,Angel Lopez-Lopez,Victor Cardenas-Salazar,Angel Faz-Cano,Earl Alexander,Jesus Roman-Calleros,Isabel Escobosa-Garcia,Fernando Escobosa-Garcia 한국토양비료학회 2014 한국토양비료학회 학술발표회 초록집 Vol.2014 No.6
Atoche-Socola, Katherine Joselyn,Arriola-Guillen, Luis Ernesto,Lopez-Flores, Ana Isabel,Garcia, Isadora Martini,Huertas-Mogollon, Gustavo,Collares, Fabricio Mezzomo,Leitune, Vicente Castelo Branco The Korean Academy of Prosthodonitics 2021 The Journal of Advanced Prosthodontics Vol.13 No.4
PURPOSE. This study aimed to compare the microshear bond strength (µSBS) of dual-cure resin cement in CAD-CAM zirconia after different cleaning techniques. MATERIALS AND METHODS. Fifty discs of zirconia-based ceramic from Ivoclar Vivadent were embedded in acrylic resin. The discs were divided into five groups according to the cleaning methods used: Group 1: drying with spraying + sandblasting with Al<sub>2</sub>O<sub>3</sub>; Group 2: washed with water and dried with spraying + sandblasting with Al<sub>2</sub>O<sub>3</sub>;Group 3: washed with distilled water and dried with spraying + sandblasting with Al<sub>2</sub>O<sub>3</sub> + zirconium oxide (Ivoclean); Group 4: washed with distilled water and dried with spraying + sandblasting with Al<sub>2</sub>O<sub>3</sub> + potassium hydroxide (Zirclean); and Group 5: washed with distilled water and dried with spraying + sandblasting with Al<sub>2</sub>O<sub>3</sub> + 1% NaClO. All of the groups were contaminated with artificial saliva for 1 minute and then cleaned. Statistical analyses were performed using ANOVA and Tukey's tests. RESULTS. There were statistically significant differences among all groups for µSBS (P < .05). The group treated with zirconium oxide (Group 3) showed the highest µSBS (18.75 ± 0.23 MPa). CONCLUSION. When applied to zirconia, the cleaning methods affected the bonding with resin cement differently.