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- 저자 : Longxiang Wu (검색결과 4 건)
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Wu Weiyu,Zhang Xuelian,He Feng,Wu Longxiang 대한독성 유전단백체 학회 2022 Molecular & cellular toxicology Vol.18 No.3
Background Colorectal cancer (CRC) is one of the most common malignancies worldwide, with the second highest incidence among men and the third incidence among women. Objective To uncover the expression of RNF115 in human colorectal cancer (CRC) tissues and cell lines, investigate its effects on CRC progression, and further explore the mechanisms. Results TCGA database showed the high transcript per million (TPM) in human CRC tissues and its relationship with poor prognosis. RNF115 was highly expressed in CRC tissues and cell lines. RNF115 contributed to the growth of CRC cells via mediating cell cycle and colony formation. RNF115 knockdown also stimulated the apoptosis of CRC cells by increasing Bax and cleaved caspase-3 expression levels. Mechanistically, RNF115 affected the proliferation and apoptosis via targeting WNT/β-catenin pathway in CRC cells. Conclusion RNF115 was highly expressed in human CRC tissues and cell lines and correlated with poor prognosis. RNF115 contributed to the growth of CRC cells via mediating cell cycle and colony formation, and also induced the apoptosis of CRC cells via targeting WNT/β-catenin pathway. RNF115 could serve as a target for CRC treatment.
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Zhi Wang,Longxiang Wu,Shiyu Tong,Xiheng Hu,Xiongbing Zu,Yuan Li,Wei He,Longfei Liu,Minfeng Chen,Lin Qi 한국통합생물학회 2016 Animal cells and systems Vol.20 No.2
Resveratrol possesses a wide spectrum of pharmacological properties and has been an ideal alternative drug for the treatment of different cancers, including prostate cancer. However, the mechanisms by which resveratrol inhibits the growth of prostate cancer are still not fully elucidated. To understand the effect of resveratrol on the apoptosis and the epithelial-tomesenchymal transition (EMT) of prostate cancer as well as its related mechanism, we investigated the potential use of resveratrol in PC-3 prostate cancer cells in vitro using real-time PCR, fluorescence-activated cell sorting, Western blotting, etc. Resveratrol suppresses the PC-3 prostate cancer cell growth and induces apoptosis. Resveratrol also influences the expression of EMT-related proteins (increased E-cadherin and decreased Vimentin expression). Finally, resveratrol also suppressed Akt phosphorylation in PC-3 cells. This study indicates that resveratrol may be a potential anti-cancer treatment for prostate cancer; moreover, it provides new evidence that resveratrol suppresses prostate cancer growth and metastasis.
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Qixiang Yan,Junchen Zhang,Wenyu Chen,Longxiang Ma,Cong Wu,Wen Zhang 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.11
The intersection structure, composed of twin shield tunnels and a transverse passage, is ubiquitous in the metros around the world. However, the dynamic characteristics of this kind of intersection structure have not been studied a lot yet. By carrying out the corresponding model tests and numerical simulations, the dynamic characteristics of this kind of intersection structure are studied in this paper, which is very helpful for the determination of the ground vibration from this kind of underground structure. The results show that the vibration of the transverse passage is more severe than the main tunnel, manifested that the frequency response function (FRF) of the transverse passage has greater magnitudes than that of the main tunnel at the locations with the same distance from the vibration source. The peak frequencies of the acceleration responses at different locations of the intersection structure under the moving train load are all located in the frequency band 44.9 − 56.1 Hz where the corresponding 1/3 octave band spectra of FRF have the largest values in the considered frequency band 31.5 − 250 Hz, indicating that the natural frequencies of the intersection structure in the frequency band 44.9~56.1 Hz have significant influences on its acceleration responses below 250 Hz induced by the moving train.
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Lian Qiang,Tang Simiao,Zhu Longxiang,Zhang Luteng,Sun Wan,Bu Shanshan,Pan Liangming,Tian Wenxi,Qiu Suizheng,Su G.H.,Wu Xinghua,Wang Xiaoyu 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.11
Blanket is of vital importance for engineering application of the fusion reactor. Nuclear heat deposition in materials is the main heat source in blanket structure. In this paper, the three-dimensional method for thermalhydraulics/ neutronics coupling analysis is developed and applied for the full-scale module of the helium-cooled ceramic breeder tritium breeding blanket (HCCB TBB) designed for China Fusion Engineering Test Reactor (CFETR). The explicit coupling scheme is used to support data transfer for coupling analysis based on cell-to-cell mapping method. The coupling algorithm is realized by the user-defined function compiled in Fluent. The threedimensional model is established, and then the coupling analysis is performed using the paralleled Coupling Analysis of Thermal-hydraulics and Neutronics Interface Code (CATNIC). The results reveal the relatively small influence of the coupling analysis compared to the traditional method using the radial fitting function of internal heat source. However, the coupling analysis method is quite important considering the nonuniform distribution of the neutron wall loading (NWL) along the poloidal direction. Finally, the structure optimization of the blanket is carried out using the coupling method to satisfy the thermal requirement of all materials. The nonlinear effect between thermal-hydraulics and neutronics is found during the blanket structure optimization, and the tritium production performance is slightly reduced after optimization. Such an adverse effect should be thoroughly evaluated in the future work.
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