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Illumina-sequencing based transcriptome study of coat color phenotypes in domestic goats
Yongdong Peng,Xiaohui Liu,Liying Geng,Ruxue Ma,Lisha Li,Jingshi Li,Chuansheng Zhang,Zhengzhu Liu,Yuanfang Gong,Xianglong Li 한국유전학회 2017 Genes & Genomics Vol.39 No.8
This study performed a comprehensive expression profiling of genes expressed in the skin of goats with three different coat colors by Illumina Sequencing. A total of 91 significantly expressed genes were detected when comparing gray skin to white skin library and these included 74 up-regulated and 17 down-regulated genes in gray skin. There were 67 differentially expressed genes between brown skin and white skin libraries, 23 of which were up-regulated and 44 were down-regulated in brown skin. When we compared brown and gray libraries, 154 differentially expressed genes were found, of which 33 showed higher expression and 121 showed lower expression in brown skin. To our surprise, MC1R, MITF, TYR and KIT showed no significant difference in expression between the goats with three skin colors, whereas ASIP was detected in white skin but not in dark skins. In this study, PMEL, TRPM1, TYRP1 and DCT were significantly upregulated in brown goat skin compare with gray and white skins. PMEL showed higher expression in gray goat skin compared with white goat skin, whereas there were no significant differences in the expression of TYRP1, TRPM1 and DCT between gray and white skin samples. In addition, ELOVL3 showed higher expression in gray goat skin than in brown and white skins, whereas there was no significant differences in the expression of ELOVL3 between brown and white skin samples. These results expand our understanding of the complex molecular mechanisms of skin physiology and melanogenesis in goat and provide a foundation for future studies.
Trapidil determines the fate of RHF rats through inhibition of ER stress
Yilin Wang,Yu Wang,Chengxi Wei,Quan Wan,Zhifei Fan,Liying Xuan,Wanru Geng,Liqun Shao,Jie Long,Junyi Gu,Ming Zhao 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.4
Pulmonary arterial hypertension is a fatal disease,especially when it causes right heart failure (RHF). However, it is difficult to treat. It has been reported thattrapidil (Tra) can improve the redox balance and cardiacconditions. In this study, we investigated the effect of Tra onRHF induced by monocrotaline (MCT) in rats. Male Wistarrats were treated with MCT or Tra. Treatment lasted 28 days,then rats were euthanized after echocardiography and catheterization. Subsequently, lungs and right ventricular myocardiawere evaluated by hematoxylin and eosin, Masson,and TUNEL staining. Protein expression was detected bywestern blotting. We found remarkably expanded rightventricle end-diastolic volume, decreased partial pressureof oxygen (PaO2), increased partial pressure of carbondioxide (PaCO2), right ventricular systolic pressure, meanpulmonary arterial pressure, lung/body weight, and liver/body weight in the RHF rat group, as well as increases inthe apoptosis rate and the expression of endoplasmic reticulumstress (ERS)-related proteins. However, these changes were significantly inhibited by Tra. Our data suggested thatinhibition of ERS is essential for improving RHF, and thattherapeutic intervention of Tra in RHF rats works by reducingERS.