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Li Wang,Hua-Jun Gong,Chun-Sheng Liu 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.3
In this paper, a composite fault-tolerant control problem is studied for a class of uncertain nonlinear systemwith asymmetric input constraint, actuator fault and external unmatched disturbance. The radial basis functionneural network (RBFNN) is employed to approximate the unknown uncertainty and asymmetric input saturation. The approximation error, external unmatched disturbance and actuator faults are integrated as the compounded disturbance. A nonlinear disturbance observer is designed to tackle the effect of the compounded disturbance whichcan be separated from the controller design. To handle the effect of asymmetric input saturation, a smooth continuousdifferentiable saturation model is explored. Adaptive NN fault-tolerant control scheme is developed toguarantee that all the signals in the closed-loop systems are semiglobally uniformly ultimately bounded (SGUUB)and the tracking errors converge to a small neighborhood of origin by choosing the appropriate design parameters. The effectiveness of the proposed control scheme is demonstrated in the simulation study.
Li Wang,Xiao-Fei Liu,Shi Yun,Xiao-Peng Yuan,Xu-Hu Mao,Chao Wu,Wei-Jun Zhang,Kai-Yun Liu,Gang Guo,Dong-Shui Lu,Wen-De Tong,Ai-Dong Wen,Quan-Ming Zou 한국미생물학회 2010 The journal of microbiology Vol.48 No.2
A multivalent fusion vaccine is a promising option for protection against Helicobacter pylori infection. In this study, UreB414 was identified as an antigenic fragment of urease B subunit (UreB) and it induced an antibody inhibiting urease activity. Immunization with UreB414 partially protected mice from H. pylori infection. Furthermore, a trivalent fusion vaccine was constructed by genetically linking heat shock protein A (HspA), H. pylori adhesin A (HpaA), and UreB414, resulting in recombinant HspA-HpaA-UreB414 (rHHU). Its protective effect against H. pylori infection was tested in BALB/c mice. Oral administration of rHHU significantly protected mice from H. pylori infection, which was associated with H. pylori-specific antibody production and Th1/Th2-type immune responses. The results show that a trivalent fusion vaccine efficiently combats H. pylori infection, and that an antigenic fragment of the protein can be used instead of the whole protein to construct a multivalent vaccine.