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RISS 인기검색어
- 검색키워드
- 저자 : Liping Qiao (검색결과 4 건)
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Assessing containment properties of underground oil storage caverns: methods and a case study
Liping Qiao,Zhechao Wang,Shucai Li,Liping Bi,Zhenhao Xu 한국지질과학협의회 2017 Geosciences Journal Vol.21 No.4
One of the most important issues in the construction of underground water-sealed oil storage caverns is the assessment of their containment properties. These properties depend on the hydrogeological condition and also engineering characteristics of the caverns. Conceptual hydrogeological model for assessing the containment properties of underground water-sealed oil storage caverns was developed. Empirical, numerical and experimental methods for assessing the containment properties were summarized. A principle for the selection of assessment methods was proposed for engineering application. It was proposed that the selected assessment method should be appropriate for the investigation stages, the research objectives and the parameters which have been determined. A five-stage flowchart for the assessment of containment properties of underground water-sealed oil storage caverns was developed. The set of assessment methods was applied to a pilot underground water-sealed oil storage facility in China. Empirical methods, fracture network method and field test methods were presented for the assessment of the containment properties of the cavern, while the other methods were introduced in previous studies.
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Novel blood-based hypomethylation of SH3BP5 is associated with very early-stage lung adenocarcinoma
Qiao Rong,Zhong Runbo,Liu Chunlan,Di Feifei,Zhang Zheng,Wang Ling,Xu Tian,Wang Yue,Dai Liping,Gu Wanjian,Han Baohui,Yang Rongxi 한국유전학회 2022 Genes & Genomics Vol.44 No.4
Background: Early detection is essential to improve the survival of lung cancer (LC). The quantitative measurement of specific DNA methylation changes in the peripheral blood could provide an efficient strategy for the detection of early cancer. Objective: We applied a candidate approach and assess the association between blood-based SH3BP5 methylation and the risk of lung adenocarcinoma (LUAD) in a case-control cohort. Methods: The methylation level of four CpG sites in the promoter of SH3BP5 gene was quantitatively determined by mass spectrometry in 171 very early-stage LUAD patients (93.6% LUAD at stage I) and 190 age and gender-matched controls. The logistic regression and non-parametric tests were used for the statistical analyses. Results: We observed a significant association between decreased methylation of SH3BP5_CpG_4 in the peripheral blood and increased risk of LUAD (odds ratio (OR) per-10% methylation = 1.51, P = 0.006, FDR = 0.024), and even for the LUAD at stage I (OR per-10% methylation = 1.53, P = 0.006, FDR = 0.024). Moreover, the lower quartile of SH3BP5_CpG_4 methylation was correlated with increased risk for LUAD with a P trend of 0.011. Further investigation disclosed that the hypomethylation of SH3BP5_CpG_4 was mostly associated with LUAD in younger subjects (OR per-10% methylation = 2.02, P = 0.010, age < 55 years old) and probably could be enhanced by advance stage. Conclusion: Our study revealed an association between blood-based SH3BP5 hypomethylation and very early-stage LUAD, which provides a novel support for the blood-based methylation signatures as a potential marker for the evaluation of cancer risk.
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Estimation of groundwater inflow into an underground oil storage facility in granite
Wang, Zhechao,Kwon, Sangki,Qiao, Liping,Bi, Liping,Yu, Liyuan Techno-Press 2017 Geomechanics & engineering Vol.12 No.6
Estimation of groundwater inflow into underground opening is of critical importance for the design and construction of underground structures. Groundwater inflow into a pilot underground storage facility in China was estimated using analytical equations, numerical modeling and field measurement. The applicability of analytical and numerical methods was examined by comparing the estimated and measured results. Field geological investigation indicated that in local scale the high groundwater inflows are associated with the appearance of open joints, fractured zone or dykes induced by shear and/or tensile tectonic stresses. It was found that 8 groundwater inflow spots with high inflow rates account for about 82% of the total rate for the 9 caverns. On the prediction of the magnitude of groundwater inflow rate, it was found that could both (Finite Element Method) FEM and (Discrete Element Method) DEM perform better than analytical equations, due to the fact that in analytical equations simplified assumptions were adopted. However, on the prediction of the spatial distribution estimation of groundwater inflow, both analytical and numerical methods failed to predict at the present state. Nevertheless, numerical simulations would prevail over analytical methods to predict the distribution if more details in the simulations were taken into consideration.
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Yang, Joon Seon,Qiao, Juan,Kim, Jin Yong,Zhao, Liping,Qi, Li,Moon, Myeong Hee American Chemical Society 2018 ANALYTICAL CHEMISTRY - Vol.90 No.5
<P>In this Article, we have reported a fully automated online method to carry out proteolysis and glycopeptide enrichment in sequence for nanoflow liquid chromatography-tandem mass spectrometry (nLC-ESI-MS/MS) analysis. By implementing two serial thermoresponsive porous polymer membrane reactors (TPPMRs), in which the TPPM could be immobilized either with trypsin for proteolysis or with lectins for glycopeptide enrichment, the entire pretreatment procedure can be performed online in about an hour. The TPPM was fabricated by coating polystyrene-maleic anhydride-<I>N</I>-isopropylacrylamide (PS-MAn-PNIPAm), which was synthesized by reversible addition-fragmentation chain transfer polymerization, on a Nylon sheet. Because of the thermoresponsive nature of PNIPAm, it formed micelle cavities and changed its morphology at elevated temperatures, resulting in enhanced interactions between the enzyme or lectins and the proteins/peptides flowing through the membrane. The performances of the TPPMs were evaluated by varying the temperature conditions and the amount of standard proteins, showing that both proteolysis and glycopeptide enrichment with online deglycosylation were highly efficient at 37 °C. The developed online serial TPPMRs-nLC-ESI-MS/MS method was applied to the human plasma sample (1.5 μL) and a total of 262 <I>N</I>-glycopeptides could be identified from 155 glycoproteins. Thus, the present work demonstrates a fully automated high speed analytical protocol for online proteolysis and glycopeptide enrichment, which is extremely useful for analyzing small amounts of the proteome samples.</P> [FIG OMISSION]</BR>
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