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      • Research on User Clustering Collaborative Filtering Algorithm

        Lihua Tian,Liguo Han,Junhua Yue 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.4

        Memory-based CF algorithms have the weakness of low real-time ability and scalability. For these issues, a SVD-based K-means clustering CF algorithm is proposed. Traditional clustering-based CF algorithms have low recommendation precision because of data sparsity. So we first fill the missing ratings by SVD prediction, and then implement k-means clustering in the filled matix. This algorithm overcomse the data sparsity issue via SVD and keep the advantage of clustering, such as good real-time ability and scalability. Experiments results show that this algorithm outperforms Pearson CF, svd CF and k-means CF.

      • Dynamic Gesture Recognition based on Image Sequence

        Lihua Tian,Liguo Han,Xiujuan Gu 보안공학연구지원센터 2015 International Journal of u- and e- Service, Scienc Vol.8 No.12

        This paper proposed an algorithm for 3D hands tracking on the learned hierarchical latent variable space, which employs a Hierarchical Gaussian Process Latent Variable Model(HGPLVM) to learn the hierarchical latent space of hands motion and the nonlinear mapping from the hierarchical latent space to the pose space simultaneously. Nonlinear mappings from the hierarchical latent space to the space of hand images are constructed using radial basis function interpolation method. With these mappings, particles can be projected into hand images and measured in the image space directly. Particle filters with fewer particles are used to track the hand on the learned hierarchical low-dimensional space. Then the Hierarchical Conditional Random Field, which can capture extrinsic class dynamics and learn the relationship between motions of hand parts and different hand gestures simultaneously, is presented to model the continuous hand gestures. Experimental results show that our proposed method can track articulated hand robustly and approving recognition performance has also been achieved on the user-defined hand gesture dataset.

      • Research on Image Segmentation based on Clustering Algorithm

        Lihua Tian,Liguo Han,Junhua Yue 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.2

        Hierarchical clustering (HC) algorithm can obtain good clustering results, but it needs large storage and computational complexity for large image processing. Anew color image segmentation algorithm based on mean shift and hierarchical clustering algorithm named MSHC is presented in this paper. MSHC algorithm preprocesses an input image by MS algorithm to form segmented regions that preserve the desirable discontinuity characteristics of image. The number of segmented regions, instead of the number of image pixels, is considered as the input data scale of HC algorithm. The proximity between each cluster is calculated to form the proximity matrix, and then ward algorithm is employed to obtain the final segmentation results. MSHC algorithm is employed on color image and medical image segmentation.

      • KCI등재

        Tie1 contributes to the development of ovarian hyperstimulation syndrome under the regulation of EGR1 in granulosa cells

        Sun Lihua,Tian Hui,Xue Songguo,Ye Hongjuan,Xue Xue,Wang Rongxiang,Liu Yu,Zhang Caixia,Chen Qiuju,Gao Shaorong 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

        The expression of tyrosine kinase with immunoglobulin-like and epidermal growth factor-like domains 1 (Tie1), a transmembrane protein expressed almost exclusively by endothelial cells, has been reported in granulosa cells. However, its significance in ovarian hyperstimulation syndrome (OHSS), which can occur after the injection of gonadotropins in infertile women undergoing controlled ovarian stimulation, is unknown. Here, we report significantly increased Tie1 and vascular endothelial growth factor (VEGF) expression in cultured granulosa cells from OHSS patients, as well as ovaries from rats with experimentally established OHSS, compared to controls, with the levels of both proteins also increasing in granulosa and SVOG cells (a nontumorigenic human granulosa-lutein cell line) treated with an acute dose of human chorionic gonadotropin (hCG). Tie1 silencing abolished the hCG-induced VEGF level in SVOG cells and attenuated the progression of OHSS in rats, as determined by histological analysis. Further studies in SVOG cells revealed that the hCG-induced upregulation of Tie1 expression involved the phosphoinositide 3-kinase/protein kinase B signaling pathway. We also report that early growth response protein 1 (EGR1), whose expression was also upregulated by hCG, bound directly to the Tie1 promoter and activated its transcription. Taken together, our results indicate that Tie1 may be a therapeutic target in cases of moderate-to-severe OHSS. Further studies are needed to address its clinical relevance.

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