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RISS 인기검색어
- 검색키워드
- 저자 : Liandong Yu (검색결과 3 건)
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Kinematics and dynamic analysis of a novel hybrid dynamics simulator
Bo Hu,Liandong Zhang,Jingjing Yu 대한기계학회 2016 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.30 No.11
A serial-parallel dynamics simulator based on serial-parallel manipulator is proposed. According to the dynamics simulator motion requirement, the proposed serial-parallel dynamics simulator formed by 3-RRS (active revolute joint-revolute joint-spherical joint) and 3-SPR (Spherical joint-active prismatic joint- revolute joint) PMs adopts the outer and inner layout. By integrating the kinematics, constraint and coupling information of the 3-RRS and 3-SPR PMs into the serial-parallel manipulator, the inverse Jacobian matrix, velocity, and acceleration of the serial-parallel dynamics simulator are studied. Based on the principle of virtual work and the kinematics model, the inverse dynamic model is established. Finally, the workspace of the (3-RRS)+(3-SPR) dynamics simulator is constructed.
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Simultaneous immunoassays of dual prostate cancer markers using a SERS-based microdroplet channel
Gao, Rongke,Cheng, Ziyi,Wang, Xiaokun,Yu, Liandong,Guo, Zhongyi,Zhao, Gang,Choo, Jaebum Elsevier 2018 Biosensors & Bioelectronics Vol.119 No.-
<P><B>Abstract</B></P> <P>The simultaneous detection of multiple biomarkers plays an important role in the accurate diagnosis of cancer. In this study, we developed a novel, surface-enhanced Raman scattering (SERS)-based microfluidic device for the simultaneous detection of free prostate-specific antigen (f-PSA) and total PSA (t-PSA) markers. A fully automatic droplet-based microfluidic platform for the rapid and sensitive detection of f-PSA and t-PSA was designed. Magnetic immunocomplexes were aligned on one side of the channel using a permanent magnet embedded in the microfluidic device, and parent microdroplets containing magnetic immunocomplexes and supernatant solutions were split into two smaller daughter droplets at the Y-shaped junction of the channel. Then, Raman signals of sequential droplets including supernatant solutions were measured for the quantitative analysis of the PSA markers. Two parallel microfluidic channels were designed and fabricated for the simultaneous detection of f-PSA and t-PSA. Our results showed a good linear response for both PSA markers in the range from 0.05 to 100 ng mL<SUP>−1</SUP>. The limits of detection were estimated to be below 0.1 ng mL<SUP>−1</SUP> for both the f-PSA and t-PSA. This SERS-based assay in a microfluidic channel was completed in 10 min without any manual incubation and washing steps. Our method is a very promising clinical tool for PSA-based screening test of prostate cancer.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We report a SERS-based microfluidic device for the detection of two prostate cancer markers. </LI> <LI> Quantitative analysis of two cancer markers in the low concentration range is possible using this device. </LI> <LI> This approach provides new insights into the accurate screening test of prostate cancer. </LI> </UL> </P>
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Yang Lu,Jiyong Park,Dian Bian,Liandong Yu,Seung-Woo Kim 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.2
We present an integrated scheme of 3-D surface profile measurements made at multiple sites concurrently by employing only a single fiber femtosecond laser as the common light source of low coherence scanning interferometry. This versatile use of an ultrashort mode-locked laser is enabled by linear scanning control of the pulse repetition rate on the source site, while diverse forms of unequal-path, non-symmetric measurements are taken with nanometer precision for different targets simply by delivering fr-scanned pulses through a fiber network. This proposed scheme has no restriction on the number of interferometer sites being integrated concurrently, allowing more diverse industrial applications of ultrashort lasers despite increased system cost and complexity.
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