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- 저자 : Lian-Quan Zhang (검색결과 4 건)
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Plasma Folate and Vitamin B <sub>12</sub> Levels in Patients with Hepatocellular Carcinoma
Cui, Lian-Hua,Quan, Zhen-Yu,Piao, Jin-Mei,Zhang, Ting-Ting,Jiang, Meng-Hui,Shin, Min-Ho,Choi, Jin-Su MDPI 2016 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.17 No.7
<P>Folate and vitamin B<SUB>12</SUB> involved in the one-carbon metabolism may play a key role in carcinogenesis and progression of hepatocellular carcinoma (HCC) through influencing DNA integrity. The purpose of this study is to evaluate the association of plasma folate and vitamin B12 levels with HCC in a case-control study on 312 HCC patients and 325 cancer-free controls. Plasma concentrations of folate and vitamin B<SUB>12</SUB> in all the subjects were measured by electrochemiluminescence immunoassay. Meanwhile, the information of HCC patients’ clinical characteristics including tumor-node-metastasis (TNM) stage, tumor size and tumor markers were collected. The patients of HCC had significantly lower folate levels than those of controls; there was no significant difference in the mean of plasma vitamin B<SUB>12</SUB> levels. We also observed an inverse association between the levels of plasma folate and HCC: the adjusted odds ratios (OR) (95% confidence intervals (CI)) of HCC from the highest to lowest quartile of folate were 0.30 (0.15–0.60), 0.33 (0.17–0.65), and 0.19 (0.09–0.38). Compared to the subjects in the lowest quartile of plasma vitamin B<SUB>12</SUB>, only the subjects in the highest quartile of vitamin B<SUB>12</SUB> exhibited a significant positive relationship with HCC, the adjusted OR was 2.01 (95% CI, 1.02–3.98). HCC patients with Stage III and IV or bigger tumor size had lower folate and higher vitamin B<SUB>12</SUB> levels. There was no significant difference in the mean plasma folate levels of the HCC cases in tumor markers status (AFP, CEA and CA19-9 levels), whereas patients with higher CEA or CA19-9 levels retained significantly more plasma vitamin B<SUB>12</SUB> than those with normal-CEA or CA19-9 level. In conclusion, plasma folate and vitamin B<SUB>12</SUB> levels could be associated with HCC, and might be used as predictors of clinical characteristics of HCC patients. However, further prospective studies are essential to confirm the observed results.</P>
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Xiao-Xuan Zhang,Jing Jiang,Ya-Nan Cai,Chun-Feng Wang,Peng Xu,Gui-Lian Yang,Quan Zhao 대한기생충학열대의학회 2016 The Korean Journal of Parasitology Vol.54 No.1
A study of 426 rabbits from 3 cities in Jilin province (Changchun City and Jilin City) and Liaoning province (Shenyang City) was conducted between May and June 2015. The overall prevalence of E. bieneusi in rabbits was 0.94% (4/426), with 0% (0/116), 1.72% (3/174), and 0.74% (1/136) in Jilin, Changchun, and Shenyang City, respectively. Only 3 farms (farm 1 and farm 3 in Changchun City, farm 8 in Shenyang City) were PCR-positive for E. bieneusi. Moreover, rabbits of more than 6 months (1.72%) had the highest E. bieneusi prevalence, followed by rabbits of 4-6 months (1.26%), 2-3 months (0.58%), and less than 1 month (0%). Analysis of ITS gene of E. bieneusi suggested that all 4 E. bieneusi isolates were genotype D, and were classified as group 1a. The present results first demonstrated the existence of zoonotic E. bieneusi in domestic rabbits in China. Effective control measures should be implemented to prevent E. bieneusi infection in domestic rabbits, other animals, and humans.
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Novel HMW glutenin genes from Aegilops tauschii and their unique structures
Wen-Jie Chen,Zhong-Wei Yuan,Lian-Quan Zhang,Xing Fan,Ze-Hong Yan,Ji-Rui Wang,You-Liang Zheng,Huai-Gang Zhang,Deng-Cai Liu 한국유전학회 2012 Genes & Genomics Vol.34 No.3
A pair of novel high-molecular-weight glutenin subunits (HMW-GS) 1Dx5.3t and 1Dy12.1**t were revealed and characterized from Ae. tauschii accession PI554324. SDS-PAGE band of 1Dx5.3t was between those of 1Bx6 and 1Bx7, while 1Dy12.1**t with slightly faster migration rate than that of 1Dy12. The lengths of 1Dx5.3t and 1Dy12.1**t were 2115 bp and 1986 bp, encoding 703 and 660 amino acid residues,respectively. Their authenticity was confirmed by successful expression of the coding regions in Escherichia coli. 1Dx5.3t is the shortest of the known Dx-type alleles. 1Dy12.1**t is also a special subunit since it has an additional cysteine in the front of the central repetitive domain. This cysteine that is not existed in previously reported Dy-type genes may be useful for improving bread wheat quality. Median-joining Network analysis indicated that 1Dy12.1**t may be a key site in the genealogy of the Glu-Dy.
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Analytical and Numerical Analysis on a New Type of Bolted Connection for Modular Steel Construction
En-Feng Deng,Jun-Yi Lian,Zhe Zhang,Zhe Liu,Ji-Jian Zhou,Shi-Quan Wang 한국강구조학회 2023 International Journal of Steel Structures Vol.23 No.4
Modular steel construction (MSC) has exhibited widespread applications in civil engineering. The inter-module connection is a key issue for the seismic performance of MSC. A detailed finite element model (FEM) of a new type of bolted connection was firstly developed. Its accuracy was validated by comparing numerical results with previous experimental results in terms of hysteretic curve and failure mode. A theoretical mechanical model was developed and its capabilities on predictions of initial rotational stiffness and ultimate moment resistance of the connection were checked through validations against test results. Further, a parametric study on several specimens with different axial load ratios, boundary conditions and section of the beams was conducted. The prediction capability of the theoretical model on seismic behavior of the connection with different beam sections was checked by comparing the skeleton curves of FEA results with theoretical ones. Subsequently, a simplified FEM was established and validated to accelerate the numerical simulation of the seismic performance of the connection.
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