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- 저자 : Li Ming-Zhang (검색결과 394 건)
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Zhang, Kan,Li, Ping,Ma, Ming,Park, Jong Hyeok Elsevier 2016 Journal of Power Sources Vol.336 No.-
<P><B>Abstract</B></P> <P>Suppressing side reactions at the cathode-electrolyte interface (CEI) is critical for alleviating capacity fading of the high-voltage (>5 V) spinel cathode material LiNi<SUB>0.5</SUB>Mn<SUB>1.5</SUB>O<SUB>4</SUB> (LNMO). The primary bottleneck in conventional nanoengineering of LNMO involves an antagonistic relationship between the positive effects of the nanometer particle size and negative effects stemming from the larger CEI area. Inspired by Buckminster Fuller's geodesic domes, we have designed a seamless LNMO hollow sphere (S-LNMO) that comprises average 120 nm-sized triangles and truncated triangle subunits by means of grain growth orientation. The “tensegrity” structure has efficiently hindered the interfacial side reaction, which occurs only within a depth of 5 nm from the surface, thereby improving its electrochemical stability. The embedded layered Li<SUB>2</SUB>TiO<SUB>3</SUB> (LTO) in bulk S-LNMO (LTO:S-LNMO) region further improved the high-rate performance, demonstrating an ∼110 mAh/g capacity with 80.9% retention after 400 cycles at 5 C and remaining stable after 900 cycles at 5 C even after being stored at 50 °C for one week.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Seamless disordered Fd3m-phase LiNi<SUB>0.5</SUB>Mn<SUB>1.5</SUB>O<SUB>4</SUB> hollow spheres are subtly designed. </LI> <LI> The seamless architecture minimized the interfacial side reaction. </LI> <LI> Nanometer depth analysis showed an electrolyte permeation distance of less than 5 nm. </LI> <LI> A layered Li<SUB>2</SUB>TiO<SUB>3</SUB> embedded in LiNi<SUB>0.5</SUB>Mn<SUB>1.5</SUB>O<SUB>4</SUB> enables high-rate performance. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Current state of research about acupuncture for the treatment of COVID-19: A scoping review
Chen Chen,Jie Zhan,Hao Wen,Xiaojing Wei,Lu Ding,Chenyang Tao,Cui Li,Peiming Zhang,Yuyuan Tang,Jing-chun Zeng,Li-ming Lu 한국한의학연구원 2021 Integrative Medicine Research Vol.10 No.-
Background Since the outbreak of coronavirus disease (COVID-19), acupuncture has been widely used in the treatment of COVID-19. The research community has responded rapidly and has already published many research articles about this topic. Methods We searched PubMed, Embase, Cochrane Library as well as CNKI, Wanfang and VIP from January 1, 2020 to July 31, 2021. The dates of publication, language of publication, methodological characteristics and the key findings were analyzed separately. The data are presented as bar graphs, structured tables and figures. Results In this scoping review, 16 research articles were included: 7 case reports, 6 observational studies, 1 review, 1 RCT and 1 nonrandomized clinical trial. The majority of the articles (81.3%) were published by Chinese scholars, 12.5% articles were by scholars in the United States, and 6.3% articles were by scholars in Iran. The included studies reported that acupuncture could alleviate the symptoms of COVID-19 patients, shorten their hospitalization days, and is effective for the elderly. There were no side effects reported. The most frequent acupoints used were LI4, PC6, ST36 and KI3. They reported many obstacles in implementing acupuncture therapy for treating COVID-19 patients. Conclusion Acupuncture has a good effect for the treatment of COVID-19, but high-quality evidence support is still lacking. Coupled with the difficulties that acupuncturists experienced during the process of treatment, the promotion of acupuncture treatment for COVID-19 faces many obstacles. Background Since the outbreak of coronavirus disease (COVID-19), acupuncture has been widely used in the treatment of COVID-19. The research community has responded rapidly and has already published many research articles about this topic. Methods We searched PubMed, Embase, Cochrane Library as well as CNKI, Wanfang and VIP from January 1, 2020 to July 31, 2021. The dates of publication, language of publication, methodological characteristics and the key findings were analyzed separately. The data are presented as bar graphs, structured tables and figures. Results In this scoping review, 16 research articles were included: 7 case reports, 6 observational studies, 1 review, 1 RCT and 1 nonrandomized clinical trial. The majority of the articles (81.3%) were published by Chinese scholars, 12.5% articles were by scholars in the United States, and 6.3% articles were by scholars in Iran. The included studies reported that acupuncture could alleviate the symptoms of COVID-19 patients, shorten their hospitalization days, and is effective for the elderly. There were no side effects reported. The most frequent acupoints used were LI4, PC6, ST36 and KI3. They reported many obstacles in implementing acupuncture therapy for treating COVID-19 patients. Conclusion Acupuncture has a good effect for the treatment of COVID-19, but high-quality evidence support is still lacking. Coupled with the difficulties that acupuncturists experienced during the process of treatment, the promotion of acupuncture treatment for COVID-19 faces many obstacles.
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Zhang, Ming,Zhao, Cheng,Li, Jinye,Xu, Liheng,Wei, Fang,Hou, Deyi,Sarkar, Binoy,Ok, Yong Sik Elsevier 2019 Journal of hazardous materials Vol.373 No.-
<P><B>Abstract</B></P> <P>Disposal of soil washing effluent (SWE) resulting from the surfactant-enhanced remediation of soil containing hydrophobic organic contaminants (HOCs)is complicated because of the presence of high levels of surfactants. The synthesized layered double hydroxides (LDHs), modified with sodium dodecyl sulfonate (SDS) in different loading amounts (organo-LDHs),were evaluated in this study as sorbents for the removal of two typical HOCs, phenanthrene (PHE) and pyrene (PYR),from a simulative SWE. The results showed that the organo-LDHs can effectively sorb PHE and PYR from the SWE within an equilibrium time of 2 h. All isotherms were linear and the sorption capabilities of the organo-LDHs increased almost linearly with the increase in the amount of SDS loaded on the LDHs. Besides, the surface areas of the organo-LDHs decreased sharply with the increase in SDS loading owing to the hindrance of the exposed surface of the LDHs by the incorporated SDS. These findings indicated that partitioning dominated the sorption process rather than adsorption, and the strong affinity of HOCs towards the organic phase in LDHs assisted in the effective removal of polycyclic aromatic hydrocarbons (PAHs) from the SWE. Furthermore, the sorption capabilities of organo-LDHs towards PHE and PYR at the higher loading amounts of SDS were much greater than that of commercial activated carbon at the higher concentration ranges of PAHs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Dodecyl sulfonate anion modified LDHs are employed for the removal of PHE and PYR in soil washing effluent (SWE). </LI> <LI> Organo-LDHs showed superior performance in PHE removal from SWE than that of commercial activated carbon. </LI> <LI> Partitioning of PHE and PYR in the organic fraction of the organo-LDHs was the main mechanism. </LI> <LI> Using organo-LDHs for the separation of HOCs from surfactants in SWE facilitated reuse of the surfactants. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Cong, Xin,Zhang, Xue-Ming,Zhang, Yan,Wei, Tai,He, Qi-Hua,Zhang, Li-Wei,Hua, Hong,Lee, Sang-Woo,Park, Kyungpyo,Yu, Guang-Yan,Wu, Li-Ling Elsevier 2018 Biochimica et biophysica acta. Molecular basis of Vol.1864 No.10
<P><B>Abstract</B></P> <P>Sjögren's syndrome (SS) is an inflammatory autoimmune disease that causes hyposecretion in salivary glands. Endothelial tight junctions (TJs) play crucial roles in salivation and barrier function of blood vessels. However, whether the alteration of endothelial TJs were involved in pathogenesis of SS was still unknown. Here, the ultrastructure and function of endothelial TJs in submandibular glands (SMGs) were detected by transmission electron microscopy and in vivo paracellular permeability assay in different aged NOD mouse model for SS. CFSE-labeled lymphocytes were injected into tail vein to trace the infiltration, while claudin-5 expression and distribution were detected by immunofluorescence, qRT-PCR, and western blot. Results showed that the stimulated salivary flow rate was gradually decreased and lymphocytic infiltration was found as age increased in 12- and 21-week-old NOD mice, but not 7-week-old NOD mice. Blood vessels were dilated, while endothelial TJ width and paracellular tracer transport were increased in 12-week-old NOD mice. Moreover, the injected CFSE-labeled lymphocytes were observed in SMGs of 12-week-old NOD mice. Claudin-5 level was increased and relocalized from the apical portion of neighboring endothelial cells to lateral membranes and cytoplasm in 12-week-old NOD mice. Additionally, the alteration of claudin-5 expression and distribution was further confirmed in labial salivary glands and bilateral parotid glands from SS patients. In cultured human microvessel endothelial cell line (HMEC-1), IFN-γ stimulation significantly increased claudin-5 expression. Taken together, we identified that the endothelial TJ barrier was disrupted and contributed to the development of salivary hyposecretion and lymphocytic infiltration in SS.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Endothelial tight junction barrier is disrupted in hyposecretory submandibular glands from Sjögren's syndrome mouse model </LI> <LI> The disrupted salivary endothelial barrier is linked with lymphocytic infiltration in Sjögren's syndrome mouse model </LI> <LI> The redistribution of claudin-5 is responsible for disrupted endothelial barrier in salivary glands from Sjögren's syndrome </LI> </UL> </P>
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Beiyuan, Jingzi,Lau, Abbe Y.T.,Tsang, Daniel C.W.,Zhang, Weihua,Kao, Chih-Ming,Baek, Kitae,Ok, Yong Sik,Li, Xiang-Dong Elsevier 2018 Science of the Total Environment Vol.612 No.-
<P><B>Abstract</B></P> <P>Remediation of CCA-contaminated soil (Cr, Cu, and As) by biodegradable chelant-enhanced washing (EDDS, <I>S,S</I>-ethylene-diamine-disuccinic-acid) needs further enhancement. This study investigated the effectiveness of coupling with pre-treatment by selective dissolution and post-treatment by soil amendments, respectively. Three groups of reagents (reductants, alkaline solvents, and organic ligands) were adopted in the pre-treatment to dissolve the oxide minerals before EDDS extraction. In the post-treatment, soil amendments (coal fly ash (CFA), acid mine drainage sludge (AMDS), green waste compost (GWC)), and their mixtures) were used for a 2-month stabilization after 2-h EDDS washing. Multi-endpoint evaluation was performed by assessing the chemical state, leachability, mobility, bioaccessibility, and plant-availability of residual metal(loid)s as well as the cytotoxicity, enzyme activities, and available nutrients of the treated soils. Pre-treatment by dithionite-citrate-bicarbonate significantly enhanced extraction efficiency, but also increased the leachability of As and Cr and bioaccessibility of Cr in the treated soils. While sodium hydroxide removed the majority of As without increasing its leachability and bioaccessibility, it increased the cytotoxicity and inhibited the acid phosphatase activity. Post-treatment with AMDS and CFA effectively controlled the mobility and leachability of residual As and Cr after EDDS washing. However, destabilized Cu was only marginally immobilized by GWC due to strong Cu-EDDS complexation. The bioaccessibility and phytoavailability of Cu was primarily reduced by EDDS washing, while those of As and Cr could be attenuated by AMDS and CFA. This study indicates that coupling chemical extraction with subsequent soil amendment plays complementary roles in mitigating effects of residual metal(loid)s and improving environmental quality.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Selective dissolution improved the removal efficiency of Cr, Cu, and As. </LI> <LI> Leachability and bioaccessibility of residual metal(loid)s were increased. </LI> <LI> NaOH washing boosted cytotoxicity and inhibited acid phosphatase activity. </LI> <LI> Mobility and leachability of residual metal(loid)s were curbed by CFA and AMDS. </LI> <LI> In contrast, bioaccessibility and plant-availability were reduced only by EDDS. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Bolan, Shiv,Kunhikrishnan, Anitha,Seshadri, Balaji,Choppala, Girish,Naidu, Ravi,Bolan, Nanthi S.,Ok, Yong Sik,Zhang, Ming,Li, Chun-Guang,Li, Feng,Noller, Barry,Kirkham, Mary Beth Elsevier 2017 Environment international Vol.108 No.-
<P><B>Abstract</B></P> <P>The last few decades have seen the rise of alternative medical approaches including the use of herbal supplements, natural products, and traditional medicines, which are collectively known as ‘Complementary medicines’. However, there are increasing concerns on the safety and health benefits of these medicines. One of the main hazards with the use of complementary medicines is the presence of heavy metal(loid)s such as arsenic (As), cadmium (Cd), lead (Pb), and mercury (Hg). This review deals with the characteristics of complementary medicines in terms of heavy metal(loid)s sources, distribution, bioavailability, toxicity, and human risk assessment. The heavy metal(loid)s in these medicines are derived from uptake by medicinal plants, cross-contamination during processing, and therapeutic input of metal(loid)s. This paper discusses the distribution of heavy metal(loid)s in these medicines, in terms of their nature, concentration, and speciation. The importance of determining bioavailability towards human health risk assessment was emphasized by the need to estimate daily intake of heavy metal(loid)s in complementary medicines. The review ends with selected case studies of heavy metal(loid) toxicity from complementary medicines with specific reference to As, Cd, Pb, and Hg. The future research opportunities mentioned in the conclusion of review will help researchers to explore new avenues, methodologies, and approaches to the issue of heavy metal(loid)s in complementary medicines, thereby generating new regulations and proposing fresh approach towards safe use of these medicines.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A first-time comprehensive overview on the health risk assessment of heavy metal(loid)s in complementary medicines </LI> <LI> Ayurvedic medicines contain toxic levels of heavy metal(loid)s including As, Cd, Hg and Pb </LI> <LI> The bioavailability of metal(loid)s in complementary medicines depends on speciation of these metals </LI> <LI> Regular intake of some complementary medicines has caused metal(loid) toxicity in humans </LI> <LI> Health risk assessment can be achieved based on the daily intake of complementary medicines and total metal(loid) content </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Interactions between heavy metal(loid)s and complementary medicines.</P> <P>[DISPLAY OMISSION]</P>
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Li, Chen-Long,Chang, Liang,Guo, Lin,Zhao, Dan,Liu, Hui-Bin,Wang, Qiu-Shi,Zhang, Ping,Du, Wen-Zhong,Liu, Xing,Zhang, Hai-Tao,Liu, Yang,Zhang, Yao,Xie, Jing-Hong,Ming, Jian-Guang,Cui, Yu-Qiong,Sun, Ying Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23
Background: ${\beta}$-elemene, extracted from herb medicine Curcuma wenyujin has potent anti-tumor effects in various cancer cell lines. However, the activity of ${\beta}$-elemene against glioma cells remains unclear. In the present study, we assessed effects of ${\beta}$-elemene on human glioma cells and explored the underlying mechanism. Materials and Methods: Human glioma U87 cells were used. Cell proliferation was determined with MTT assay and colony formation assay to detect the effect of ${\beta}$-elemene at different doses and times. Fluorescence microscopy was used to observe cell apoptosis with Hoechst 33258 staining and change of glioma apoptosis and cell cycling were analyzed by flow cytometry. Real-time quantitative PCR and Western-blotting assay were performed to investigated the influence of ${\beta}$-elemene on expression levels of Fas/FasL, caspase-3, Bcl-2 and Bax. The experiment was divided into two groups: the blank control group and ${\beta}$-elemne treatment group. Results: With increase in the concentration of ${\beta}$-elemene, cytotoxic effects were enhanced in the glioma cell line and the concentration of inhibited cell viability ($IC_{50}$) was $48.5{\mu}g/mL$ for 24h. ${\beta}$-elemene could induce cell cycle arrest in the G0/G1 phase. With Hoechst 33258 staining, apoptotic nuclear morphological changes were observed. Activation of caspase-3,-8 and -9 was increased and the pro-apoptotic factors Fas/FasL and Bax were upregulated, while the anti-apoptotic Bcl-2 was downregulated after treatment with ${\beta}$-elemene at both mRNA and protein levels. Furthermore, proliferation and colony formation by U87 cells were inhibited by ${\beta}$-elemene in a time and does-dependent manner. Conclusions: Our results indicate that ${\beta}$-elemene inhibits growth and induces apoptosis of human glioma cells in vitro. The induction of apoptosis appears to be related with the upregulation of Fas/FasL and Bax, activation of caspase-3,-8 and -9 and downregulation of Bcl-2, which then trigger major apoptotic cascades.
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Numerical simulation of Rayleigh-Bénard convection of nanofluids in rectangular cavities
Li Zhang,You-Rong Li,Ji-Ming Zhang 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.8
In order to understand the characteristics of Rayleigh-Bénard convection of nanofluids in a rectangular cavity, a series of threedimensional numerical simulations were carried out by using the finite volume method. The working mediums were Al 2 O 3 -water and CuO-water nanofluids, and Rayleigh number varied from 1708 to 1.5×10 5 . Results show that the critical Rayleigh number of the Rayleigh-Bénard convection onset increases with the increase of the volume fraction of nanoparticles, which hints that nanoparticles make the flow become more stable. Furthermore, the critical Rayleigh number decreases with the increase of the aspect ratio of the cavity. After convection appears, the average Nusselt number at the bottom wall increases, but the flow intensity and the oscillation frequency decrease with the increase of the volume fraction of nanoparticles. With the increase of Rayleigh number, there exist four bifurcation sequences, which are Steady flow (SF) → Periodic oscillatory flow (POF) → Chaotic flow (CF), SF → POF → SF → POF →CF, SF → POF → Multiple periodic oscillatory flow (MPOF) → POF →CF and SF → POF → MPOF →CF.
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Zhang Ying,Wang Peng,Jin Mei-xian,Zhou Ying-qi,Ye Liang,Zhu Xiao-juan,Li Hui-fang,Zhou Ming,Li Yang,Li Shao,Liang Kang-yan,Wang Yi,Gao Yi,Pan Ming-xin,Zhou Shu-qin,Peng Qing 한국조직공학과 재생의학회 2023 조직공학과 재생의학 Vol.20 No.3
BACKGROUND: Human umbilical cord mesenchymal stem cells (hUCMSCs) have emerged as promising therapy for immune and inflammatory diseases. However, how to maintain the activity and unique properties during cold storage and transportation is one of the key factors affecting the therapeutic efficiency of hUCMSCs. Schisandrin B (SchB) has many functions in cell protection as a natural medicine. In this study, we investigated the protective effects of SchB on the hypothermic preservation of hUCMSCs. METHODS: hUCMSCs were isolated from Wharton’s jelly. Subsequently, hUCMSCs were exposed to cold storage (4 C) and 24-h re-warming. After that, cells viability, surface markers, immunomodulatory effects, reactive oxygen species (ROS), mitochondrial integrity, apoptosis-related and antioxidant proteins expression level were evaluated. RESULTS: SchB significantly alleviated the cells injury and maintained unique properties such as differentiation potential, level of surface markers and immunomodulatory effects of hUCMSCs. The protective effects of SchB on hUCMSCs after hypothermic storage seemed associated with its inhibition of apoptosis and the anti-oxidative stress effect mediated by nuclear factor erythroid 2–related factor 2 signaling. CONCLUSION: These results demonstrate SchB could be used as an agent for hypothermic preservation of hUCMSCs.
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