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RISS 인기검색어
- 검색키워드
- 저자 : Leiming Wang (검색결과 3 건)
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Analysis of the Effects of Warm Weather Conditions on Fuel Tank Flammability
Xiaozhen Wang,Leiming Geng,Weihua Liu 한국항공우주학회 2024 International Journal of Aeronautical and Space Sc Vol.25 No.2
There have been many civil aircraft fuel tank deflagration accidents under warm weather conditions around the world. To ensure flight safety, the International Aviation Authorities have established quantitative standard limit indicators for the flammability exposure time of fuel tanks of civil transport aircraft on the ground and during climb stages under warm weather conditions above 26.7 °C (80°F). However, in the practice of airworthiness certification of a certain civil aircraft, people found that the smooth development of airworthiness certification work has been restricted due to the lack of in-depth research on the calculation method, influencing factors, and preventive measures of fuel tank flammability exposure time under warm weather conditions. Accordingly, this paper establishes a simulation model based on the physical structure of the fuel system of a civil aircraft, discusses the variation law of the flammability of the fuel tank under warm weather conditions based on MIL- STD-210A hot-weather atmosphere, and analyzes the influence of factors, such as ground temperature, flight phase, cruising time, and fuel type on the flammability of the fuel tank. The results show that compared with normal climate conditions, warm weather conditions will increase the exposure time of fuel tank flammability; at the same time, factors, such as short range, climbing stage, and low-flash point fuel, have more significant effects on fuel tank flammability in warm climates. The research results have a guiding significance for the proposal of fuel flammability airworthiness compliance method under warm weather conditions.
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Jian Ren,Xiao Xiao,Li Ruofei,Lv Cheng,Zhang Yu,Leiming Wang,Tao Hong,Hongqi Zhang,Wang Yibo 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Cavernous malformations (CMs) invading the central nervous system occur in ~0.16–0.4% of the general population, often resulting in hemorrhages and focal neurological deficits. Further understanding of disease mechanisms and therapeutic strategies requires a deeper knowledge of CMs in humans. Herein, we performed single-cell RNA sequencing (scRNA-seq) analysis on unselected viable cells from twelve human CM samples and three control samples. A total of 112,670 high-quality cells were clustered into 11 major cell types, which shared a number of common features in CMs harboring different genetic mutations. A new EC subpopulation marked with PLVAP was uniquely identified in lesions. The cellular ligand‒receptor network revealed that the PLVAP-positive EC subcluster was the strongest contributor to the ANGPT and VEGF signaling pathways in all cell types. The PI3K/AKT/mTOR pathway was strongly activated in the PLVAP-positive subcluster even in non-PIK3CA mutation carriers. Moreover, endothelial-to-mesenchymal transition (EndMT) cells were identified for the first time in CMs at the single-cell level, which was accompanied by strong immune activation. The transcription factor SPI1 was predicted to be a novel key driver of EndMT, which was confirmed by in vitro and in vivo studies. A specific fibroblast-like phenotype was more prevalent in lesion smooth muscle cells, hinting at the role of vessel reconstructions and repairs in CMs, and we also confirmed that TWIST1 could induce SMC phenotypic switching in vitro and in vivo. Our results provide novel insights into the pathomechanism decryption and further precise therapy of CMs.
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Na Mi,Guirui Yu,Wuefa Wen,Xiaomin Sun,Shusen Wang,Leiming Zhang,Xia Song 한국기상학회 2009 Asia-Pacific Journal of Atmospheric Sciences Vol.45 No.2
The Qianyanzhou (QYZ) forest site is located in the mid-subtropical region under typical subtropical continentalmonsoon climate. Despite its plentiful water and heat resources, changes in their seasonal distributions result in frequent occurrences of seasonal drought, influencing both the structure and function of forest ecosystems. In order to examine the effects of drought stress on energy and water fluxes and the related physiological processes, we used tower flux measurements from 2003 and 2004 from the QYZ site and the ecosystemmodel EALCO (Ecological Assimilation of Land and Climate Observations). The model explained almost 90%of the variance in the daily LE for both years; whereas 71%and 55% of the variance in H for 2003 and 2004, respectively. Simulations suggested that, during the 2003 summer drought, about 80% of water extraction by roots occurred below 0.45 m, and canopy stomatal conductance decreased in response to soil dryness at a threshold r (relative water content) of 0.5 m. The response of canopy stomatal conductance appeared to be linked to the soil water exposed to themajority of the roots, even if substantialwater was being extracted fromgreater depth. The decrease of canopy stomatal conductance made the ratio of transpiration to ET relatively constant along the years with only a small difference. The different extent of the seasonal drought resulted in different water fluxes for the two years with more distinct influence on evaporation than on transpiration.
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