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Kim Harin,Ji Wonjun,Lee Jong Won,Jo Min-Woo,Yun Sung-Chol,Lee Sei Won,Choi Chang-Min,Lee Geun Dong,Lee Hui Jeong,Cho Eulah,Lee Yura,Chung Seockhoon 대한의학회 2023 Journal of Korean medical science Vol.38 No.31
Background: Lung cancer is associated with significant psychological distress, including fear of progression (FoP). Because insomnia and depression are highly prevalent and associated with FoP, we examined the association between FoP, insomnia, and depression in cancer patients. Furthermore, we tested the mediation effect of cancer-related dysfunctional beliefs about sleep (C-DBS) on this association. Methods: We analyzed data collected from patients with surgically resected non-small cell lung cancer from a single-center randomized controlled study investigating digital healthcare applications. Baseline demographic and clinical variables were collected. In addition, selfreported questionnaires including the Fear of Progression Questionnaire-Short Form, Patients Health Questionnaire-9 items (PHQ-9), Insomnia Severity Index, and C-DBS were administered. Results: Among the 320 enrolled patients with lung cancer, a regression model showed that FoP was predicted by age (β = −0.13, P = 0.007), PHQ-9 (β = 0.35, P < 0.001), and C-DBS (β = 0.28, P < 0.001). Insomnia did not directly influence FoP, but C-DBS mediated the association. Depression directly influenced FoP, but C-DBS did not mediate this association. Conclusion: Among patients with surgically resected lung cancer, C-DBS mediated the effects of severity of insomnia on FoP. Depression directly influenced FoP, but C-DBS did not influence this association. To reduce FoP among patients with lung cancer, C-DBS should be addressed in the cognitive behavioral therapy module.
Lee, Yura,Shin, Soo-Yong,Kim, Ji-Young,Kim, Jeong Hun,Seo, Dong-Woo,Joo, Segyeong,Park, Joong-Yeol,Kim, Woo Sung,Lee, Jae-Ho,Bates, David W. Korean Society of Medical Informatics 2015 Healthcare Informatics Research Vol.21 No.4
<P><B>Objectives</B></P><P>To evaluate the mobile health applications (apps) developed by a single tertiary hospital in Korea with a particular focus on quality and patient safety.</P><P><B>Methods</B></P><P>Twenty-three mobile health apps developed by Asan Medical Center were selected for analysis after exclusion of the apps without any relationship with healthcare or clinical workflow, the apps for individual usage, and the mobile Web apps. Two clinical informaticians independently evaluated the apps with respect to the six aims for quality improvement suggested by the United States Institute of Medicine. All discrepancies were resolved after discussion by the two reviewers. The six aims observed in the apps were reviewed and compared by target users.</P><P><B>Results</B></P><P>Eleven apps targeted patients, the other 12 were designed for healthcare providers. Among the apps for patients, one app also had functions for healthcare providers. 'My cancer diary' and 'My chart in my hand' apps matched all the six aims. Of the six aims, <I>Timeliness</I> was the most frequently observed (20 apps), and <I>Equity</I> was the least observed (6 apps). <I>Timeliness</I> (10/11 vs. 10/12) and <I>Patient safety</I> (10/11 vs. 9/12) were frequently observed in both groups. In the apps for patients, <I>Patient-centeredness</I> (10/11 vs. 2/12) and <I>Equity</I> (6/11 vs. 0/12) were more frequent but <I>Efficiency</I> (5/11 vs. 10/12) was less frequent.</P><P><B>Conclusions</B></P><P>Most of the six aims were observed in the apps, but the extent of coverage varied. Further studies, evaluating the extent to which they improve quality are needed.</P>
English E-Mails of Administrative Staff
Yura Lee,Jihyeon Jeon 한국응용언어학회 2018 응용 언어학 Vol.34 No.3
Korean learners study English language mostly at educational settings without having specific training for writing e-mails in English and then later, when their job requires literacy on English e-mails, they struggle to learn to write them for the required business communication. In order to gain practical information for writing e-mails in English at workplace, the current study explored the authentic e-mails sent and received between the administrative staff members of ‘A’ Symphony Orchestra and their overseas working partners, with specific focus on the move-schemes of the e-mails and frequently used expressions for each move. The collected e-mails were analyzed using NVIVO 12 and WordSmith 7.0. The results indicated that the e-mails were using eight moves, with four to five moves for each e-mail message in average. The eight moves were (1) to open the message, (2) to have small talk to build relationship, (3) to request for information or action, (4) to provide information, (5) to respond to previous request or information, (6) to remind of an unresolved issue, (7) to close the message, and (8) to sign-off. Other than three functional moves, which were to open, close, and sign-off the message, ‘to request’ was used most frequently, followed by ‘to respond to previous request or information’ and ‘to provide information.’ The language used in each move covered various topics relevant for their collaboration and was mostly informal and direct in manner. The results and discussion will provide useful information for English e-mails instruction.
Lee, Yura,Bae, Kyoung Jun,Chon, Hae Jung,Kim, Seong Hwan,Kim, Soon Ae,Kim, Jiyeon Korean Society for Molecular and Cellular Biology 2016 Molecules and cells Vol.39 No.5
Dovitinib (TKI258) is a small molecule multi-kinase inhibitor currently in clinical phase I/II/III development for the treatment of various types of cancers. This drug has a safe and effective pharmacokinetic/pharmacodynamic profile. Although dovitinib can bind several kinases at nanomolar concentrations, there are no reports relating to osteoporosis or osteoblast differentiation. Herein, we investigated the effect of dovitinib on human recombinant bone morphogenetic protein (BMP)-2-induced osteoblast differentiation in a cell culture model. Dovitinib enhanced the BMP-2-induced alkaline phosphatase (ALP) induction, which is a representative marker of osteoblast differentiation. Dovitinib also stimulated the translocation of phosphorylated Smad1/5/8 into the nucleus and phosphorylation of mitogen-activated protein kinases, including ERK1/2 and p38. In addition, the mRNA expression of BMP-4, BMP-7, ALP, and OCN increased with dovitinib treatment. Our results suggest that dovitinib has a potent stimulating effect on BMP-2-induced osteoblast differentiation and this existing drug has potential for repositioning in the treatment of bone-related disorders.
Lee, Yura,Jung, Min-Young,Shin, Gee Won,Bahn, Sangwoo,Park, Taezoon,Cho, Insook,Lee, Jae-Ho Korean Society of Medical Informatics 2018 Healthcare Informatics Research Vol.24 No.3
<P><B>Objectives</B></P><P>The usability of clinical information systems (CISs) is known to be an essential consideration in ensuring patient safety as well as integrating clinical flow. This study aimed to determine how usability and safety guidelines of CIS consider clinical workflow through a systematic review in terms of the target systems, methodology, and guideline components of relevant articles.</P><P><B>Methods</B></P><P>A literature search was conducted for articles published from 2000 to 2015 in PubMed, Cochrane, EMBASE, Web of Science, and CINAHL. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement method was employed. Articles containing recommendations, principles, and evaluation items for CIS usability and safety were included. The selected articles were classified according to article type, methodology, and target systems. Taking clinical workflow into consideration, the components of guidelines were extracted and classified.</P><P><B>Results</B></P><P>A total of 7,401 articles were identified by keyword search. From the 76 articles remaining after abstract screening, 15 were selected through full-text review. Literature review (n = 7) was the most common methodology, followed by expert opinions (n = 6). Computerized physician order entry (n = 6) was the most frequent system. Four articles considered the entire process of clinical tasks, and two articles considered the principles of the entire process of user interface affecting clinical workflow. Only two articles performed heuristic evaluations of CISs.</P><P><B>Conclusions</B></P><P>The usability and safety guidelines of CISs need improvement in guideline development methodology and with consideration of clinical workflow.</P>