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- 저자 : Le Duc Thuan (검색결과 5 건)
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Huan, Le Cong,Tran, Phuong-Thao,Phuong, Cao Viet,Duc, Phan Huy,Anh, Duong Tien,Hai, Pham The,Huong, Le Thi Thu,Thuan, Nguyen Thi,Lee, Hye Jin,Park, Eun Jae,Kang, Jong Soon,Linh, Nguyen Phuong,Hieu, Tr Elsevier 2019 Bioorganic chemistry Vol.92 No.-
<P><B>Abstract</B></P> <P>In search for novel small molecules with antitumor cytotoxicity via activating procaspase-3, we have designed and synthesized three series of novel (E)-<I>N</I>′-benzylidene-4-oxoquinazolin-3(4<I>H</I>)-yl)acetohydrazides (<B>5a-j, 6a-h,</B> and <B>7a-h)</B>. On the phenyl ring ò the benzylidene part, three different substituents, including 2-OH-4-OCH<SUB>3</SUB>, 4-OCH<SUB>3</SUB>, and 4-N(CH<SUB>3</SUB>)<SUB>2</SUB>, were introduced, respectively. Biological evaluation showed that the acetohydrazides in series <B>5a-j</B>, in which the phenyl ring of the benzylidene part was substituted by 2-OH-4-OCH<SUB>3</SUB> substituent, exhibited potent cytotoxicity against three human cancer cell lines (SW620, colon; PC-3, prostate; NCI-H23, lung). Most of the compounds, in this series, especially compounds <B>5c, 5b</B> and <B>5h,</B> also significantly activated caspase-3 activity. Among these, compound <B>5c</B> displayed 1.61-fold more potent than PAC-1 as caspase-3 activator. Cell cycle analysis showed that compounds <B>5b</B>, <B>5c</B>, and <B>5h</B> significantly arrested the cell cycle in G1 phase. Further apoptotic studies also demonstrated compounds <B>5b</B>, <B>5c</B>, and <B>5h</B> as strong apoptotic cell death inducers. The docking simulation studies showed that these compounds could activate procaspase <I>via</I> chelating Zn<SUP>2+</SUP> ion bound to the allosteric site of the zymogen.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Novel (<I>E</I>)-<I>N</I>′-benzylidene-2-(4-oxoquinazolin-<I>3(4H)-yl</I>)acetohydrazides were synthesized. </LI> <LI> The acetohydrazides <B>5a-i</B> exhibited potent cytotoxicity against three human cancer cell lines. </LI> <LI> A number of cytotoxic compounds exhibited good caspase activation activity. </LI> <LI> The cytotoxic compounds were shown to arrest cells at G1 phase. </LI> <LI> The cytotoxic compounds were shown as strong apoptotic inducers. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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New look at secure performance of massive MIMO with low-resolution DACs
Anh-Tu Le,Dinh-Thuan Do,Nhu-Ngoc Dao,Nhan Duc Nguyen,Adão Silva 한국통신학회 2023 ICT Express Vol.9 No.4
Since the requirement of secure transmission for massive multiple-input–multiple-output (mIMO) is high, we consider a secure massive MIMO system in presence of multiple digital to analog converters (DACs). We deal with complicated performance analysis of the proposed system including a base station, a legitimate user, and an eavesdropper while these nodes are equipped with multiple antennas. In particular, we intend to present the closed-form expression for the ergodic secrecy rate of the system and also calculate the optimal power allocation for better performance gain. The simulation analysis shows that quantization bits, transmit signal to noise ratio at the base station, and power allocation plays a major role in enhancing the performance of the system.
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Mechanical Design of Robot Head with Human-like Emotions
Nguyen Khac Toan,Le Duc Thuan,Le Bao Long,Nguyen Truong Thinh 제어로봇시스템학회 2021 제어로봇시스템학회 국제학술대회 논문집 Vol.2021 No.10
One of the fields that has detonated lately dependent on the AI platform is humanoid robots. The facial expressions of robots, then again, are getting less and less attention. The design of a robot head that communicates a wide range of human-like expressions is described in this paper. The eye-eyelid, lip-jaw, and neck were the three main parts of the robot head under investigation. Mechanical structure of human head such as number of degrees of freedom, size, ability of joints, and major muscle groups to create movements in each part are determined based on anatomy. Then, facial expressions are analyzed dependent on AUs to find out reasonable control points. The mechanical structures of each part were designed to try to replicate the movement and expression as closely as expected. Additionally, proportions, sizes, distances of the designs, such as CoP-CoP, tr-n, n-sn, and so on, must closely resemble those of a human head. The robot head in this article is designed and modeled on an Asian human head. The result of the design, the head section is made up of three mechanisms connected by a shaft that runs through the entire head. Through the experimental process, the robot head can perform 6 of the basic expressions and movements like a real human head.
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Truong, Phuong Kim,Lao, Thuan Duc,Doan, Thao Phuong Thi,Huyen Le, Thuy Ai Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.6
DNA methylation of tumor suppressor gene promoters is the most frequent phenomenon leading to inactivation of function, consequently driving malignant cell transformation. Cyclin D2 is implicated in tumor suppression. In our study, we carried out the MSP assay to evaluation the methylation status at CpG islands in the cyclin D2 promoter in breast cancer cases from the Vietnamese population. The results showed that the frequency of methylation reached 62.1% (59 of 95 breast cancer tumors), but was low in non-cancer specimens at 10% (2 of 20 non-cancer specimens). Additionally, with an RR (relative risk) and OR (odd ratios) of 6.21 and 14.8, DNA hypermethylation of cyclin D2 increased the possibility of malignant transformation. Our results confirmed the cyclin D2 hypermethylation could be used as the potential biomarker which could be applied in prognosis and early diagnosis of Vietnamese breast cancer patients.
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Urinary incontinence after COVID-19 vaccination: a case study in an 8-year-old boy
Dao Thi Loi,Nguyen Trung Kien,Nguyen Xuan Bai,Le Kieu Dung,Duong Khanh Linh,Bui Duc Manh,Nguyen Le Cam Anh,Hoang Van Thuan 대한백신학회 2024 Clinical and Experimental Vaccine Research Vol.13 No.3
There have been many studies on the adverse effects of coronavirus disease 2019 (COVID-19) vaccines but the urinary incontinence after COVID-19 vaccination is rare. Here, we report an 8-year-old boy presented to outpatient department, Thai Binh University of Medicine Hospital, Thai Binh, Vietnam with complaints of urinary incontinence for the past 2 weeks, following the first dose of the messenger RNA vaccine. He had no other abnormalities in clinical and laboratory exams. This clinical situation suggested vaccine side effects. No specific treatment was administered upon diagnosis without toilet and bladder training. Subsequent monitoring revealed a gradual reduction in symptoms over 2 months, with complete recovery achieved at the 14th week from the onset of symptoms, without necessitating any medical intervention. This case highlights the need for thorough evaluation and assessment of potential adverse effects following vaccination, including uncommon presentations.
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