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Regulation of Drosophila Vasa In Vivo through Paralogous Cullin-RING E3 Ligase Specificity Receptors
Kugler, Jan-Michael,Woo, Jae-Sung,Oh, Byung-Ha,Lasko, Paul American Society for Microbiology 2010 Molecular and cellular biology Vol.30 No.7
<B>ABSTRACT</B><P>In <I>Drosophila</I> species, molecular asymmetries guiding embryonic development are established maternally. Vasa, a DEAD-box RNA helicase, accumulates in the posterior pole plasm, where it is required for embryonic germ cell specification. Maintenance of Vasa at the posterior pole requires the deubiquitinating enzyme Fat facets, which protects Vasa from degradation. Here, we found that Gustavus (Gus) and Fsn, two ubiquitin Cullin-RING E3 ligase specificity receptors, bind to the same motif on Vasa through their paralogous B30.2/SPRY domains. Both Gus and Fsn accumulate in the pole plasm in a Vasa-dependent manner. Posterior Vasa accumulation is precocious in <I>Fsn</I> mutant oocytes; Fsn overexpression reduces ovarian Vasa levels, and embryos from Fsn-overexpressing females form fewer primordial germ cells (PGCs); thus, Fsn destabilizes Vasa. In contrast, endogenous Gus may promote Vasa activity in the pole plasm, as <I>gus</I> females produce embryos with fewer PGCs, and posterior accumulation of Vas is delayed in <I>gus</I> mutant oocytes that also lack one copy of <I>cullin-5</I>. We propose that Fsn- and Gus-containing E3 ligase complexes contribute to establishing a fine-tuned steady state of Vasa ubiquitination that influences the kinetics of posterior Vasa deployment.</P>
Beam commissioning of the SπRIT time projection chamber
Jhang, Genie,Barney, Jon,Estee, Justin,Isobe, Tadaaki,Kaneko, Masanori,Kurata-Nishimura, Mizuki,Cerizza, Giordano,Santamaria, Clementine,Lee, Jung Woo,Lasko, Paweł,Łukasik, Jerzy,Lynch, William G.,McI 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol. No.
Beam Commissioning of the SπRIT Time Projection Chamber
Genie Jhang,Jon Barney,Justin Estee,Tadaaki Isobe,Masanori Kaneko,Mizuki Kurata-Nishimura,Giordano Cerizza,Clementine Santamaria,Jung Woo Lee,Paweł Lasko,Jerzy Łukasik,William G. Lynch,Alan B. McIntos 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.69 No.2
The SπRIT Time Projection Chamber (TPC) was constructed at Michigan State University in the U.S.A. and transported to the Radioactive Isotope Beam Factory at RIKEN in Japan. In October 2015, the SπRIT TPC was commissioned with 200 AMeV 79Se beams outside the SAMURAI dipole magnet. The experimental setup consists of the SπRIT TPC, a Multiplicity Trigger Array, a KATANA array, and a Active Veto array. The TPC is fully equipped with a newly-developed read-out electronics system, GET electronics. The trigger logic to select events of the TPC based on the ancillary detectors was tested. The analysis software, SπRITROOT, was developed to analyze the SπRIT TPC data to determine the best trigger logic for upcoming experiments.
Extending the dynamic range of electronics in a Time Projection Chamber
Estee, J.,Lynch, W.G.,Barney, J.,Cerizza, G.,Jhang, G.,Lee, J.W.,Wang, R.,Isobe, T.,Kaneko, M.,Kurata-Nishimura, M.,Murakami, T.,Shane, R.,Tangwancharoen, S.,Tsang, C.Y.,Tsang, M.B.,Hong, B.,Lasko, P. Elsevier 2019 Nuclear instruments & methods in physics research. Vol.944 No.-
<P><B>Abstract</B></P> <P>When Time Projection Chambers (TPCs) are used in low to intermediate heavy ion collisions, the mass and momentum range of the emitted particles cover a wide range in energy losses. Many TPC readout electronics currently only have a single gain output with a fixed dynamic range. In a recent set of experiments using the SAMURAI Pion-Reconstruction and Ion-Tracker (S π RIT) TPC, it was important to simultaneously measure relativistic pions and heavy ion tracks from the same collisions. As the ionization from a track’s energy loss is collected and multiplied by the anode wires, a distribution of image charges is induced on the TPC read-out pads. If the avalanche on a wire is large enough, the charge collected by pads directly underneath will saturate the readout electronics; pads farther away in the distribution will not be saturated. Using these unsaturated pads and the known pad distribution function, we can estimate the charge on saturated pads, increasing the dynamic range by a factor of 5.</P>