HYDRAULIC MODELLING FOR THE DEVELOPMENT OF PUMPED-STORAGE SCHEMES

KLASINC ROMAN,LARCHER MARKUS,PREDIN ANDREJ,BILUS IGNACIJO,KASTREVC MITJA 한국수자원학회 2005 한국수자원학회 학술대회 Vol.2005 No.1

Numerical investigation of glass windows under near-field blast

Chiara Bedon,Damijan Markovic,Vasilis Karlos,Martin Larcher Techno-Press 2023 Coupled systems mechanics Vol.12 No.2

The determination of the blast protection level and the corresponding minimum load-bearing capacity for a laminated glass (LG) window is of crucial importance for safety and security design purposes. In this paper, the focus is given to the window response under near-field blast loading, i.e., where relatively small explosives would be activated close to the target, representative of attack scenarios using small commercial drones. In general, the assessment of the load-bearing capacity of a window is based on complex and expensive experiments, which can be conducted for a small number of configurations. On the other hand, nowadays, validated numerical simulations tools based on the Finite Element Method (FEM) are available to partially substitute the physical tests for the assessment of the performance of various LG systems, especially for the far-field blast loading. However, very little literature is available on the LG window performance under near-field blast loads, which differs from far-field situations in two points: i) the duration of the load is very short, since the blast wavelength tends to increase with the distance and ii) the load distribution is not uniform over the window surface, as opposed to the almost plane wave configuration for far-field configurations. Therefore, the current study focuses on the performance assessment and structural behaviour of LG windows under near-field blasts. Typical behavioural trends are investigated, by taking into account possible relevant damage mechanisms in the LG window components, while size effects for target LG windows are also addressed under a multitude of blast loading configurations.

Understanding and Optimization of Pulsed SET Operation in HfO_x-Based RRAM Devices for Neuromorphic Computing Applications

Padovani, Andrea,Woo, Jiyong,Hwang, Hyunsang,Larcher, Luca IEEE 2018 IEEE electron device letters Vol.39 No.5

<P>We use experiments and device simulations to investigate pulsed SET operation of HfO<SUB>2</SUB>-based RRAM devices for their possible use as electronic synapses. The application of a train of identical pulses only allows for an abrupt change of the device current, which is not suitable for synaptic devices. By using simulations, we link the microscopic properties and changes of the conductive filament during the pulsed operation to the measured conductance and its dependence on pulse voltage, width, and number. The results allow us to derive guidelines that we use to design optimized SET pulses (or pulse trains) allowing extending the conventional binary operation of HfO<SUB>2</SUB>-based RRAMs to the multi-level cell operation required by electronic synapses.</P>

A Forgotten Entity following Breast Implant Contracture: Does Baker Need a Change?

Andrea Pagani,Matthias M. Aitzetmüller,Lorenz Larcher 대한성형외과학회 2022 Archives of Plastic Surgery Vol.49 No.3

Although capsular contracture represents one of the most important complications after breast augmentation, local inflammation and fibrosis can lead, to capsular calcification, an often-forgotten radiological sign of capsular contracture. In this article, the authors present a clinical case of breast implant calcification in an 81-year-old patient. Although this complication has been rarely described, the literature was reviewed to clarify the role of the local microenvironment in capsular contracture and calcification. At present, capsular contracture patients are classified using the conventional Baker score and the histological Wilflingseder classification. As it was not possible to consider capsular calcification when classifying our patient using the traditional scores, the authors propose an updated version of the current scale.

Indications, Outcomes, and Complications of Pedicled Propeller Perforator Flaps for Upper Body Defects: A Systematic Review

Lazzeri, Davide,Huemer, Georg M.,Nicoli, Fabio,Larcher, Lorenz,Dashti, Talal,Grassetti, Luca,Li, Qingfeng,Zhang, Yixin,Spinelli, Giuseppe,Agostini, Tommaso Korean Society of Plastic and Reconstructive Surge 2013 Archives of Plastic Surgery Vol.40 No.1

Background The aim of this investigation was to systematically review the current literature to provide the best data for indications, outcomes, survival, and complication rates of pedicled propeller perforator flaps for upper body defects. Methods A comprehensive literature review for articles published from January 1991 to December 2011 was performed using the PubMed, Medline, and Cochrane Databases. Articles without available full-text, single case reports or papers with excessive missing data were excluded. Papers reporting pedicle-perforator (propeller) flaps used for lower extremity reconstruction were excluded from meta-analysis. Results From the initial 1,736 studies our search yielded, 343 studies qualified for the second stage of selection. Of 117 full-text reports screened, 41 studies, met the definitive inclusion and exclusion criteria. Of the selected 41 articles, 26 were case series, original papers or retrospective reviews and were included, whereas 15 were case report papers and therefore were excluded. Two hundred ninety-five propeller flaps were reported to have been used in a total of 283 patients. Indications include repair of trauma-induced injuries, post-trauma revision surgery, cancer resection, chronic infection, pressure sores, and chronic ulcers with a major complication rate (3.3%) comparable to that of free flaps. No specific exclusion criteria for the procedure were presented in the studies reviewed. Conclusions Pedicled propeller flaps are a versatile and safe reconstructive option that are easy and quick to raise and that provide unlimited clinical solutions because of the theoretical possibility of harvesting them based on any perforator chosen among those classified in the body.

Linking Conductive Filament Properties and Evolution to Synaptic Behavior of RRAM Devices for Neuromorphic Applications

Jiyong Woo,Padovani, Andrea,Kibong Moon,Myounghun Kwak,Larcher, Luca,Hyunsang Hwang IEEE 2017 IEEE electron device letters Vol.38 No.9

<P>We perform a comparative study of HfO2 and Ta2O5 resistive switching memory (RRAM) devices for their possible application as electronic synapses. By means of electrical characterization and simulations, we link their electrical behavior (digital or analog switching) to the properties and evolution of the conductive filament (CF). More specifically, we identify that bias-polarity-dependent digital switching in HfO2 RRAM is primarily related to the creation and rupture of an oxide barrier. Conversely, the modulation of the CF size in Ta2O5 RRAM allows bias-polarity-independent analog switching with multiple states. Therefore, when the Ta2O5 RRAM is used to implement a synapse in multilayer perceptron neural networks operated by back-propagation algorithms, patterns in handwritten digits can be recognized with high accuracy. Index</P>

Indications, Outcomes, and Complications of Pedicled Propeller Perforator Flaps for Upper Body Defects: A Systematic Review

Davide Lazzeri,Georg M. Huemer,Fabio Nicoli,Lorenz Larcher,Talal Dashti,Luca Grassetti,Qingfeng Li,Yixin Zhang,Giuseppe Spinelli,Tommaso Agostini 대한성형외과학회 2013 Archives of Plastic Surgery Vol.40 No.1

Background The aim of this investigation was to systematically review the current literature to provide the best data for indications, outcomes, survival, and complication rates of pedicled propeller perforator flaps for upper body defects. Methods A comprehensive literature review for articles published from January 1991 to December 2011 was performed using the PubMed, Medline, and Cochrane Databases. Articles without available full-text, single case reports or papers with excessive missing data were excluded. Papers reporting pedicle-perforator (propeller) flaps used for lower extremity reconstruction were excluded from meta-analysis. Results From the initial 1,736 studies our search yielded, 343 studies qualified for the second stage of selection. Of 117 full-text reports screened, 41 studies, met the definitive inclusion and exclusion criteria. Of the selected 41 articles, 26 were case series, original papers or retrospective reviews and were included, whereas 15 were case report papers and therefore were excluded. Two hundred ninety-five propeller flaps were reported to have been used in a total of 283 patients. Indications include repair of trauma-induced injuries, post-trauma revision surgery, cancer resection, chronic infection, pressure sores, and chronic ulcers with a major complication rate (3.3%) comparable to that of free flaps. No specific exclusion criteria for the procedure were presented in the studies reviewed. Conclusions Pedicled propeller flaps are a versatile and safe reconstructive option that are easy and quick to raise and that provide unlimited clinical solutions because of the theoretical possibility of harvesting them based on any perforator chosen among those classified in the body.

Clinical Use of [-2]proPSA (p2PSA) and Its Derivatives (%p2PSA and Prostate Health Index) for the Detection of Prostate Cancer: A Review of the Literature

Alberto Abrate,Giovanni Lughezzani,Giulio Maria Gadda,Giuliana Lista,Ella Kinzikeeva,Nicola Fossati,Alessandro Larcher,Paolo Dell’Oglio,Francesco Mistretta,Nicolòmaria Buffi,Giorgio Guazzoni,Massimo L 대한비뇨의학회 2014 Investigative and Clinical Urology Vol.55 No.7

Prostate-specific antigen (PSA) is recognized as an organ-specific marker with low specificityand sensitivity in discriminating prostate cancer (PCa) from other benign conditions,such as prostatic hyperplasia or chronic prostatitis. Thus, in the case of clinicalsuspicion, a PCa diagnosis cannot be made without a prostate biopsy. [-2]proPSA(p2PSA), a precursor of PSA, has been investigated as a new marker to accurately detectPCa. The aim of this systematic review was to discuss the available literature regardingthe clinical validity and utility of p2PSA and its derivatives, p2PSA/fPSA (%p2PSA)and the Prostate Health Index (PHI). A systematic search of the PubMed and Scopuselectronic databases was performed in accordance with the PRISMA statement(http://www.prisma-statement.org), considering the time period from January 1990 toJanuary 2014 and using the following search terms: proprostate specific antigen, proenzymePSA, proPSA, [-2]proPSA, p2PSA, Prostate Health Index, and PHI. To date,115 studies have been published, but only 35 were considered for the qualitativeanalysis. These studies suggested that p2PSA is the most cancer-specific form of PSA,being preferentially expressed in PCa tissue and being significantly elevated in the serumof men with PCa. It is now evident that p2PSA, %p2PSA, and PHI measurementsimprove the specificity of the available tests (PSA and derivatives) in detecting PCa. Moreover, increasing PHI values seem to correlate with more aggressive disease. Somestudies have compared p2PSA and its derivatives with other new biomarkers and foundp2PSA to be significantly more accurate. Indeed, the implementation of these tests inclinical practice has the potential to significantly increase the physician’s ability to detectPCa and avoid unnecessary biopsies, while also having an effective impact on costs. Further studies in large, multicenter, prospective trials are required to confirm theseencouraging results on the clinical utility of these new biomarkers.