Anti-tumor effect of Euphorbia hirta on Ehrlich's ascites carcinoma in mice

Kumarappan, CT,Sunderi, S Karpagam Kumara,Jaswanth, A,Lakshmi, S Mohana,Mandal, Subhash C Kyung Hee Oriental Medicine Research Center 2007 Oriental pharmacy and experimental medicine Vol.7 No.2

Anti-tumor activity of Euphorbia hirta (50 mg/kg and 100 mg/kg) has been evaluated against Ehrlich's ascites carcinoma (EAC) in Swiss albino mice. Intraperitoneal (i.p) administration of Euphorbia hirta was effective in reducing solid tumor mass development induced by EAC cells. It exhibited significant anti-tumor activity in mice, when used at the dose of 100 mg/kg/day i.p., for 14days. The administration of Euphorbia hirta (100 mg/kg/day i.p.) resulted in an increase (P<0.001) of the life span (59.9%) of ascites tumor bearing mice as compared to the control group. After 14 days, on developed tumor masses, Euphorbia hirta administration brought about significant reduction in tumor volume and it reverse the changes in the hematological parameters, responding to tumor inoculation. The results are indicative of the anti-tumor activity of Euphorbia hirta against EAC induced tumor in a dose dependent manner.

Anti-tumor effect of Euphorbia hirta on Ehrlich’s ascites carcinoma in mice

CT Kumarappan,S Karpagam Kumara Sunderi,A Jaswanth,S Mohana Lakshmi,Subhash C Mandal 경희대학교 융합한의과학연구소 2007 Oriental Pharmacy and Experimental Medicine Vol.7 No.2

Anti-tumor activity of Euphorbia hirta (50 mg/kg and 100 mg/kg) has been evaluated against Ehrlich’s ascites carcinoma (EAC) in Swiss albino mice. Intraperitoneal (i.p) administration of Euphorbia hirta was effective in reducing solid tumor mass development induced by EAC cells. It exhibited significant anti-tumor activity in mice, when used at the dose of 100 mg/kg/day i.p., for 14 days. The administration of Euphorbia hirta (100 mg/kg/day i.p.) resulted in an increase (P < 0.001) of the life span (59.9%) of ascites tumor bearing mice as compared to the control group. After 14 days, on developed tumor masses, Euphorbia hirta administration brought about significant reduction in tumor volume and it reverse the changes in the hematological parameters, responding to tumor inoculation. The results are indicative of the anti-tumor activity of Euphorbia hirta against EAC induced tumor in a dose dependent manner.

Experimental and Numerical Investigation of Ballistic Impact Analysis on Kevlar Reinforced Polymer Composites and Shape Memory Alloy Sheet Reinforced Kevlar Epoxy Polymer Composites

Prabu Ravindran,Kumarappan Mani Kumar,Selvam Rangasamy,Kuttynadar Rajammal Vijaya Kumar 한국고분자학회 2022 폴리머 Vol.46 No.4

In the present study, the ballistic impact resistance of kevlar reinforced polymer composites and shape memoryalloy sheet reinforced kevlar epoxy polymer composites have been compared numerically and experimentally. The testspecimens have been fabricated by the hand layup method, and the ballistic impact test has been conducted accordingto NIJ Level IIIA. In the current research, a new method has been proposed to measure the ballistic impact resistanceof the material by using Image J software. From the test results, it has been observed that reinforcement of shape memoryalloy in kevlar epoxy polymer composites has increased the ballistic impact resistance by 89-145% for the damaged areacompared with plain kevlar reinforced epoxy polymer composite. Also, the damaged area observed in the numerical andthe experimental results is almost the same.

Antioxidant Activity of Talinum portulacifolium (Forssk) Leaf Extracts

Rao, Thalapaneni Nageswara,Kumarappan, Chidambaram,Lakshmi, Sabapathi Mohana,Mandal, Subhash C Kyung Hee Oriental Medicine Research Center 2008 Oriental pharmacy and experimental medicine Vol.8 No.4

The aim of the study is to investigate the antioxidant activity through, reducing power, 2, 2-diphenyl-1-picryl hydrazyl radical (DPPH), nitric oxide radical (NO), superoxide radical, hydrogen peroxide radical ($H_2O_2$) scavenging activity and the amount of total phenolic compounds of chloroform, ethyl acetate, methanol and aqueous extracts of the leaves of Talinum portulacifolium. Chloroform extract of leaves of T. portulacifolium showed highest antioxidant activity, with a direct relationship between activity and concentration of extracts ($15-240\;{\mu}g/mL$). Among all the extracts, the highest amount of the total polyphenolic compounds was found in the chloroform extract. Chloroform extract of T. portulacifolium showed an important free radical scavenging activity towards the DPPH, NO, Superoxide and $H_2O_2$ radicals, with $IC_{50}$ values of 133.26, 165.75, 156.34 and $135.29\;{\mu}g/mL$, respectively. In the lipid peroxidation assay, extracts of chloroform and ethyl acetate showed a remarkable inhibitory activity. The extracts showed significant activity in all the experiments but lower than the standard antioxidant, ascorbic acid.

Antioxidant Activity of Talinum portulacifolium (Forssk) Leaf Extracts

Thalapaneni Nageswara Rao,Chidambaram Kumarappan,Sabapathi Mohana Lakshmi,Subhash C Mandal 경희대학교 융합한의과학연구소 2008 Oriental Pharmacy and Experimental Medicine Vol.8 No.4

The aim of the study is to investigate the antioxidant activity through, reducing power, 2, 2- diphenyl-1-picryl hydrazyl radical (DPPH), nitric oxide radical (NO), superoxide radical, hydrogen peroxide radical (H2O2) scavenging activity and the amount of total phenolic compounds of chloroform, ethyl acetate, methanol and aqueous extracts of the leaves of Talinum portulacifolium. Chloroform extract of leaves of T. portulacifolium showed highest antioxidant activity, with a direct relationship between activity and concentration of extracts (15 - 240 μg/mL). Among all the extracts, the highest amount of the total polyphenolic compounds was found in the chloroform extract. Chloroform extract of T. portulacifolium showed an important free radical scavenging activity towards the DPPH, NO, Superoxide and H2O2 radicals, with IC50 values of 133.26, 165.75, 156.34 and 135.29 μg/mL, respectively. In the lipid peroxidation assay, extracts of chloroform and ethyl acetate showed a remarkable inhibitory activity. The extracts showed significant activity in all the experiments but lower than the standard antioxidant, ascorbic acid. The aim of the study is to investigate the antioxidant activity through, reducing power, 2, 2- diphenyl-1-picryl hydrazyl radical (DPPH), nitric oxide radical (NO), superoxide radical, hydrogen peroxide radical (H2O2) scavenging activity and the amount of total phenolic compounds of chloroform, ethyl acetate, methanol and aqueous extracts of the leaves of Talinum portulacifolium. Chloroform extract of leaves of T. portulacifolium showed highest antioxidant activity, with a direct relationship between activity and concentration of extracts (15 - 240 μg/mL). Among all the extracts, the highest amount of the total polyphenolic compounds was found in the chloroform extract. Chloroform extract of T. portulacifolium showed an important free radical scavenging activity towards the DPPH, NO, Superoxide and H2O2 radicals, with IC50 values of 133.26, 165.75, 156.34 and 135.29 μg/mL, respectively. In the lipid peroxidation assay, extracts of chloroform and ethyl acetate showed a remarkable inhibitory activity. The extracts showed significant activity in all the experiments but lower than the standard antioxidant, ascorbic acid.

Emotional Effect in Conversations

( Karthikeyan Jagadeesan ),( Annapurani Kumarappan ) 한국감성과학회 2023 한국감성과학회 국제학술대회(ICES) Vol.2023 No.-

The identification and interpretation of emotions within conversations is an emerging field in the realm of natural language processing. Emotion recognition systems are primarily known for their usefulness across various customer-centric businesses, whether it involves providing customer support in the hospitality industry or conducting sentiment analysis in social media. It is increasingly important for any customer-facing system to possess emotional awareness. In this paper we present the analysis of post conversation emotion (Emotional Effect). This concept delves into the previously unexplored notion of post-conversation emotional effect on individuals, presenting a valuable opportunity for further research. Analyzing emotions at the individual utterance level may not accurately capture the overall emotions held by the participants towards the end of the conversation. Our analysis on the post conversation emotional effect indicates that the involved parties carry distinct emotional effects, which can potentially influence their subsequent interactions..

α-Glucosidase and α-Amylase Inhibitory Activity of Senna surattensis

Ellappan Thilagam,Balasubramaian Parimaladevi,Chidambaram Kumarappan,Subhash Chandra Mandal 사단법인약침학회 2013 Journal of Acupuncture & Meridian Studies Vol.6 No.1

In this study, we investigated the inhibitory effects of ethanolic extract of the leaves of Senna surattensis (EESS) on α-glucosidase and α-amylase. We also studied the in vitro antidiabetic activity of S. surattensis using the glucose uptake by isolated rat hemidiaphragm model. In vitro studies using mammalian α-glucosidase extracted from the small intestine homogenate of mouse showed that the extract was found to be more effective in inhibiting the activities of maltase [half maximal inhibitory concentration (IC50): 209.15 μg/mL] and sucrase (IC50: 366.44 μg/mL) when compared with the control group (acarbose). The extract of S. surattensis were further quantified with respect to porcine pancreatic α-amylase inhibition using the chromogenic 3,5-dinitrosalicylic acid method. Interestingly, S. surattensis was also found to exhibit α-amylase (IC50: 123.95 μg/mL) inhibitory activity. The glucose uptake in the rat hemidiaphragm was significantly (p < 0.01) increased by EESS (220.95 ± 5.4 mg/g/30 minute) when compared with the control group. The total polyphenolic content of EESS was found to be 98 μg pyrocatechol/mg of the extract. These results suggest that EESS inhibited carbohydrate digestive enzymes and increased the peripheral uptake of glucose. This study endorses the use of this plant for further studies to determine their potential for managing type II diabetes.