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Kumar, Rajesh,Li, Xiaojie,Kong, Xiangying The Korean Neurosurgical Society 2015 Journal of Korean neurosurgical society Vol.46 No.4
Objective : To study the effect of early intervention and rehabilitation in the expression of aquaporin-4 and ultrastructure changes on cerebral palsy pups model induced by intrauterine infection. Methods : 20 pregnant Wistar rats were consecutively injected with lipopolysaccharide intraperitoneally. 60 Pups born from lipopolysaccharide group were randomly divided into intervention group (n=30) and non-intervention group (n=30); intervention group further divided into early intervention and rehabilitation group (n=10), acupuncture group (n=10) and consolidate group (n=10). Another 5 pregnant rats were injected with normal saline intraperitoneally; 30 pups born from the normal saline group were taken as control group. The intervention group received early intervention, rehabilitation and acupuncture treatment. The motor functions of all pups were assessed via suspension test and modified BBB locomotor score. Aquaporin-4 expression in brain tissue was studied through immunohistochemical and western-blot analysis. Ultrastructure changes in damaged brain and control group were studied electron-microscopically. Results : The scores of suspension test and modified BBB locomotor test were significantly higher in the control group than the intervention and non intervention group (p<0.01); higher in the intervention group than the non-intervention group (p<0.01). The expression of Aquaporin-4 was lower in intervention and non intervention group than in the control group (p<0.01); also lower in non-intervention group than the intervention group (p<0.01). Marked changes were observed in ultrastructure of cortex and hippocampus CAI in brain damaged group. Conclusion : Early intervention and rehabilitation training can improve the motor function in offspring with brain injury and reduce the expression of aquaporin-4 in damaged brain.
Kumar Rajesh,Li Xiaojie,Kong Xiangying 대한신경외과학회 2015 Journal of Korean neurosurgical society Vol.58 No.1
Objective : To study the effect of early intervention and rehabilitation in the expression of aquaporin-4 and ultrastructure changes on cerebral palsy pups model induced by intrauterine infection. Methods : 20 pregnant Wistar rats were consecutively injected with lipopolysaccharide intraperitoneally. 60 Pups born from lipopolysaccharide group were randomly divided into intervention group (n=30) and non-intervention group (n=30); intervention group further divided into early intervention and rehabilitation group (n=10), acupuncture group (n=10) and consolidate group (n=10). Another 5 pregnant rats were injected with normal saline intraperitoneally; 30 pups born from the normal saline group were taken as control group. The intervention group received early intervention, rehabilitation and acupuncture treatment. The motor functions of all pups were assessed via suspension test and modified BBB locomotor score. Aquaporin-4 expression in brain tissue was studied through immunohistochemical and western-blot analysis. Ultrastructure changes in damaged brain and control group were studied electron-microscopically. Results : The scores of suspension test and modified BBB locomotor test were significantly higher in the control group than the intervention and non intervention group (p<0.01); higher in the intervention group than the non-intervention group (p<0.01). The expression of Aquaporin-4 was lower in intervention and non intervention group than in the control group (p<0.01); also lower in non-intervention group than the intervention group (p<0.01). Marked changes were observed in ultrastructure of cortex and hippocampus CAI in brain damaged group. Conclusion : Early intervention and rehabilitation training can improve the motor function in offspring with brain injury and reduce the expression of aquaporin-4 in damaged brain.
Cai, Yudong,He, ZhiSong,Shi, Xiaohe,Kong, Xiangying,Gu, Lei,Xie, Lu Korean Society for Molecular and Cellular Biology 2010 Molecules and cells Vol.30 No.2
Protein-DNA interactions play an essential role in transcriptional regulation, DNA repair, and many vital biological processes. The mechanism of protein-DNA binding, however, remains unclear. For the study of many diseases, researchers must improve their understanding of the amino acid motifs that recognize DNA. Because identifying these motifs experimentally is expensive and time-consuming, it is necessary to devise an approach for computational prediction. Some in silico methods have been developed, but there are still considerable limitations. In this study, we used a machine learning approach to develop a new sequence-based method of predicting protein-DNA binding residues. To make these predictions, we used the properties of the micro-environment of each amino acid from the AA Index as well as conservation scores. Testing by the cross-validation method, we obtained an overall accuracy of 94.89%. Our method shows that the amino acid micro-environment is important for DNA binding, and that it is possible to identify the protein-DNA binding sites with it.
Yudong Cai,ZhiSong He,Xiaohe Shi,Xiangying Kong,Lei Gu,Lu Xie 한국분자세포생물학회 2010 Molecules and cells Vol.30 No.2
Protein-DNA interactions play an essential role in tran-scriptional regulation, DNA repair, and many vital biologi-cal processes. The mechanism of protein-DNA binding, however, remains unclear. For the study of many diseases, researchers must improve their understanding of the amino acid motifs that recognize DNA. Because identifying these motifs experimentally is expensive and time-consuming, it is necessary to devise an approach for computational pre-diction. Some in silico methods have been developed, but there are still considerable limitations. In this study, we used a machine learning approach to develop a new se-quence-based method of predicting protein-DNA binding residues. To make these predictions, we used the proper-ties of the micro-environment of each amino acid from the AAIndex as well as conservation scores. Testing by the cross-validation method, we obtained an overall accuracy of 94.89%. Our method shows that the amino acid micro-environment is important for DNA binding, and that it is possible to identify the protein-DNA binding sites with it.