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Koga, K.,Descalzi, G.,Chen, T.,Ko, H.G.,Lu, J.,Li, S.,Son, J.,Kim, T.,Kwak, C.,Huganir, Richard L.,Zhao, M.g.,Kaang, B.K.,Collingridge, Graham L.,Zhuo, M. Cell Press 2015 Neuron Vol.85 No.2
Chronic pain can lead to anxiety and anxiety can enhance the sensation of pain.@?Unfortunately, little is known about the synaptic mechanisms that mediate these re-enforcing interactions. Here we characterized two forms of long-term potentiation (LTP) in the anterior cingulate cortex (ACC); a presynaptic form (pre-LTP) that requires kainate receptors and a postsynaptic form (post-LTP) that requires N-methyl-D-aspartate receptors. Pre-LTP also involves adenylyl cyclase and protein kinase A and is expressed via a mechanism involving hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. Interestingly, chronic pain and anxiety both result in selective occlusion of pre-LTP. Significantly, microinjection of the HCN blocker ZD7288 into the ACC in vivo produces both anxiolytic and analgesic effects. Our results provide a mechanism by which two forms of LTP in the ACC may converge to mediate the interaction between anxiety and chronic pain.
DESIGN OF POTENT K+ CHANNEL OPENERS BY PHARMACOPHORE MODEL
Koga, Hiroshi,Ohta, Masateru,Sato, Haruhiko,Ishizawa, Takenori,Nabata, Hiroyuki 전남대학교 약품개발연구소 1996 약품개발연구지 Vol.4 No.1
A pharmacophore model which explains rationally structure-activity relationships of chemically diverse potent K+ channel openers, has been constructed. Potent benzopyran derivatives with thioamide, amide, and (N-cyano)amidine groups at the 4-position have been designed using the model.
Koga, Sayo,Seto, Mika,Moriyama, Shigeaki,Kikuta, Toshihiro The Korean Dental Society of Anesthsiology 2017 Journal of Dental Anesthesia and Pain Medicine Vol.17 No.3
Background: It is important to evaluate preoperative anxiety and prepare sedation when performing dental surgery under local anesthesia. Spielberger's State-Trait Anxiety Inventory (STAI) is useful for predicting preoperative anxiety. State anxiety is defined as a subjective feeling of nervousness. Reduction in the number of the state anxiety items (questions) will be clinically important in allowing us to predict anxiety more easily. Method: We analyzed the STAI responses from 1,252 patients who visited our institution to undergo dental surgery under local anesthesia. Multiple linear regression analysis was conducted for 9 groups comprising anxiety level determinations using the STAI; we then developed a coefficient of determination and a regression formula. We searched for a group satisfying the largest number of requirements for regression expression while setting any necessary conditions for accurately predicting anxiety before dental surgery under local anesthesia. Results: The regression expression from the group determined as normal for preoperative state anxiety was deemed the most suitable for predicting preoperative anxiety. Conclusion: It was possible to reduce the number of items in the STAI by focusing on "Preoperative anxiety before dental surgery."
Thermoregulatory Responses of Swamp Buffaloes and Friesian Cows to Diurnal Changes in Temperature
Koga, A.,Kurata, K.,Furukawa, R.,Nakajima, M.,Kanai, Y.,Chikamune, T. Asian Australasian Association of Animal Productio 1999 Animal Bioscience Vol.12 No.8
Several reports have indicated that a rectal temperature of buffaloes is easily influenced by their surroundings. To clarify an effect of changing environmental temperature on thermoregulatory responses of buffaloes, an environment with diurnal temperature changes of $25^{\circ}C$ to $35^{\circ}C$ was created using an artificial climate laboratory. Three swamp buffaloes and three Friesian cows were exposed to three different experimental periods as follows: Period 1 (constant temperature of $30^{\circ}C$, Period 2 (diurnally changing temperature) and Period 3 (diurnally changing temperature and fasting). Heat production, rectal temperature, respiration rate, heart rate and respiration volume were measured during each period. Rectal temperature of the buffaloes fluctuated diurnally with the changing temperature (Periods 2 and 3), but remained constant in cows. Mean heat production was significantly lower in buffaloes than in cows in Period 2 and 3. However, the maximum rectal temperature and the increment of heat production were not always lower in buffaloes than in cows during Period 2. These results show that a rectal temperature and heat production in buffaloes are markedly influenced by the diurnal changes in temperature. Compared with Bos Taurus cows, the differences may be attributed to the physiological features of buffaloes including a high heat conductivity of their bodies and an lower heat production.
Koga, A.,Kurata, K.,Ohata, K.,Nakajima, M.,Hirose, H.,Furukawa, R.,Kanai, Y.,Chikamune, T. Asian Australasian Association of Animal Productio 1999 Animal Bioscience Vol.12 No.6
From previous studies, there is a strong possibility in buffaloes that the marked increase in blood volume (BV) under hot conditions contributes to heat transportation from the rectum to the skin. The present study was done to clarify changes with environmental temperature on water-shift between blood and extracellular fluid (ECF), heat distribution between the rectum and the skin, and blood flow rates (BFR) at the hind legs (reflecting the skin surface). Four buffaloes and four Friesian cows were successively exposed to three different temperatures of $20^{\circ}C$, $30^{\circ}C$ and $35^{\circ}C$. BV and ECF volume were measured with Evans' blue and sodium-thiocyanate dilution methods, respectively. Rectal and subcutaneous (as the skin) temperatures were measured by copper-constantan thermocouples. BFR were measured by a supersonic blood flow meter. With an increase in environmental temperature, skin temperature in buffaloes increased significantly than cows, but rectal temperature was not significantly different between two species. BV, especially plasma compartment, increased significantly in only buffaloes, while ECF volume did not change in both species. BFR increased significantly in buffaloes, but not in cows. From these results, the increased of BV may be caused by water flowing from ECF compartment. The water-shift may induce the increase of BFR and skin temperature. It is suggested in the present study that internal changes of blood compartment in buffaloes contribute to transfer of heat to the skin surface.