http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
심적환$^{(R)}$이 흉통 흉민에 대하여 미치는 영향에 대한 다기관 무작위배정 이중맹검 임상연구
장인수,고창남,이인,박정미,김세현,김상우,Jang Insoo,Ko Changnam,Lee In,Park Jung-mi,Kim Sehyun,Kim Sangwoo 대한한의학회 2005 대한한의학회지 Vol.26 No.2
Objectives: This was a double blinded, randomized, placebo-controlled clinical study for evaluation of safety and effective dose finding of Cardiotonic Pills$^{(R)}$ in patients with chest pain and discomfort. Cardiotonic Pills$^{(R)}$ are composed of Salviae Miltiorrhizae Radix (丹蔘), Notoginseng Radix (三七根) and Borneolum (龍腦). Major effects of Salviae Miltiorrhizae Radix and Notoginseng Radix are vasodilatation, sedation and analgesic action. Borneolum has an antibacterial effect, and can stimulate the central nervous system. All of these substances are oriental herbs that have been used for a long time in east Asia. Cardiotonic Pills fi received Investigational New Drug (IND) approval from the Food and Drug Administration (FDA) in the USA and 40 million people in the world take this pill. We performed a phase IV clinical study to confirm its efficacy and safety in patients who have probable cardiogenic or psychogenic chest pain or chest stifling. Methods: This study was planned for a multi-center clinical trial including four university hospitals of oriental medicine in Korea. This was the first time to evaluate the 'planning treatment according to diagnosis (辨證施治)' of chest pain or chest discomfort according to oriental medical guidelines. The patients who were included in this trial were adult volunteers from 20 to 70 years old who had chest pain or chest discomfort more than twice during a recent month, and we received written consent to participate in this study from all of them. After administration of Cardiotonic Pills$^{(R)}$ for 8 weeks, number of occurrences, duration, appearance and degree of chest pain or chest discomfort was observed and degree of symptoms (severity of illness, global improvement) were measured using a patient's global assessment composite scale. Results: In the patient's global assessment scale, the severity of illness of the Cardiotonic Pills$^{(R)}$ group (n=25) was 14/25=0.56 but of the placebo group (n=25) was 7/25=0.28 (p-value=0.0449). This result indicates Cardiotonic Pills$^{(R)}$have a positive effect on the symptoms of chest pain and discomfort. However, the global improvement of the Cardiotonic Pills$^{(R)}$group was 23/25=0.92, and of the placebo group was 22/25=0.88 (p-value=0.6374). The total symptom score of the Cardiotonic Pills$^{(R)}$ group was $1.68\pm20.06$, and of the placebo group was $16.76\pm72.l4$(p-value=0.2285). The number of symptom events of the Cardiotonic Pills$^{(R)}$ group was $72\pm29.78$, and of the placebo group (n=25) was $10.80\pm38.42$ (pvalue=0.3660). We could not find any effects on the other factors examined besides the severity of illness, beyond the difference of standard deviations. Conclusions: Cardiotonic Pills$^{(R)}$ significantly reduced chest pain and chest discomfort in patients. Therefore, we expect that Cardiotonic Pills$^{(R)}$ will be helpful for patients with chest pain and chest discomfort not only caused by heart disease but also by other diseases.
Jeoung, Hye-Young,Lee, Soo-Kyoung,Park, Jee-Yong,Kim, Hyun-Jeong,Yang, Sun-Joo,Lee, Sang Kyu,Ko, Jin A,Yang, Hyoung-Seok,Park, Changnam,Kim, Sung-Hee,Kang, Hae-Eun,Choi, Jun-Gu Elsevier 2018 Journal of equine veterinary science Vol.69 No.-
<P><B>Abstract</B></P> <P>Contagious equine metritis is a highly transmissible venereal disease of horses caused by the bacterium, <I>Taylorella equigenitalis</I>. After the first identification of <I>T. equigenitalis</I> in Korea in 2015, targeted surveillance of Thoroughbreds was conducted using real-time polymerase chain reaction. Initially, the prevalence of <I>T. equigenitalis</I> in the Thoroughbred population tested was 13.5% (71/526). All positive animals were placed under quarantine and treated according to previously described protocols (Jeoung et al., J Equine Vet Sci, 2016; 47:42–6). After the initial outbreak identification, annual national surveillance for <I>T. equigenitalis</I> was conducted from 2015 to 2017, and by 2017, prevalence was reduced to 1.0% (22/2,171). Most positive cases were located in Jeju province, the major horse-rearing region in Korea. A total of 12 <I>T. equigenitalis</I> strains were isolated during the surveillance period, and multilocus sequence typing (MLST) and eBURST analysis were applied to determine epidemiological characteristics. All Korean strains showed a unique MLST allelic profile (1-2-1-2-2-2-1; <I>gltA</I>-<I>gyrB</I>-<I>fh</I>-<I>shmt</I>-<I>tyrB</I>-<I>adk</I> in order) and were classified as sequence type 55. In addition, they showed little relationship with <I>T. equigenitalis</I> strains isolated from other countries. Considering the unique biological and genetic characteristics of the Korean isolates, effective quarantine measures and continued surveillance will be required to eradicate the disease and prevent incursions of additional <I>T. equigenitalis</I> strains into Korea.</P> <P><B>Highlights</B></P> <P> <UL> <LI> In Korea, a national <I>T. equigenitalis</I> surveillance program conducted in Thoroughbred horses showed a decrease in prevalence from 13.5% in 2015 to 1.0% in 2017. </LI> <LI> Characterization of 12 Korean <I>T. equigenitalis</I> isolates showed identical bacteriological properties and demonstrated a unique multilocus sequence typing (MLST) profile (1-2-1-2-2-1). </LI> <LI> All Korean <I>T. equigenitalis</I> isolates were classified as MLST sequence type 55 (ST55) and showed little genetic relationship with isolates from other countries. </LI> </UL> </P>