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- 저자 : Kim Junghyun (검색결과 870 건)
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Junghyun Kim(Junghyun Kim),Dae-Eun Kim(Dae-Eun Kim),Eunseok Park(Eunseok Park),Dae-Jin Kim(Dae-Jin Kim),Hwanhee Kim(Hwanhee Kim) 한국보건의료윤리학회 2023 한국보건의료윤리학회지 Vol.2 No.1
Background: The purpose of this study is to provide basic data on the necessity and direction of education to establish a desirable bioethics view by identifying bioethics awareness of the Life-sustaining Treatment Decision Act among biomedical laboratory science student and nursing students attending K University. Methods: From October 30 to November 5, 2022, the final 279 people (144 in biomedical laboratory science and 135 in nursing) were analyzed through a structured survey of 29 questions. Results: As a result of comparing the presence or absence of learning and the degree of awareness of the life-sustaining treatment decision act, the presence or absence of learning p<.001. There was a statistically significant difference in cognitive degree p<.001. Conclusion: It is suggested that continuous research should be conducted to confirm the perception of biomedical ethics of Biomedical laboratory science students and nursing students and to find the need and direction of education to establish a desirable bioethics.
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The Role of High-Mobility Group Box-1 Protein in the Development of Diabetic Nephropathy
Kim, Junghyun,Sohn, Eunjin,Kim, Chan-Sik,Jo, Kyuhyung,Kim, Jin Sook S. Karger AG 2011 American journal of nephrology Vol.33 No.6
<P>Abstract</P><P><I>Background/Aims:</I> The purpose of the experiment reported here was to assess the involvement of high-mobility group box-1 (HMGB1), receptor for advanced glycation end products (RAGE) and nuclear factor (NF)-κB signaling pathway in the development of rat diabetic nephropathy. <I>Methods:</I> Diabetes was induced by intraperitoneal streptozotocin injection in 7-week-old male rats. At 20 weeks of age, renal expression of HMGB1 was detected by immunohistochemistry. The expression of RAGE and NF-κB activity was studied by Western blot and electrophoretic mobility shift assay in renal tissues of normoglycemic and diabetic rats, respectively. <I>Results:</I> HMGB1 was highly expressed in both the cytoplasmic and nuclear patterns in diabetic renal glomerular cells and tubular epithelial cells, although in normal rats, HMGB1 was expressed only in the cell nuclei. The expression of RAGE, a potential receptor for HMGB1, and NF-κB activity were also greater in diabetic than in normal rats. Moreover, diabetes increased the binding of NF-κB to the RAGE promoter. <I>Conclusion:</I> These findings suggest that hyperglycemia-induced HMGB1 release may induce the renal injury in diabetic rats, and that the pathogenic role of HMGB1 might be dependent on RAGE and through activation of NF-κB.</P><P>Copyright © 2011 S. Karger AG, Basel</P>
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Kim, Junghyun,Kim, Chan-Sik,Sohn, Eunjin,Kim, Jin Sook SPANDIDOS PUBLICATIONS 2016 MOLECULAR MEDICINE REPORTS Vol. No.
<P>The aim of the present study was to assess the involvement of the high-mobility group box-1 (HMGB1) protein, receptor for advanced glycation end products (RAGE) and nuclear factor (NF)-κB signaling pathway in the development of diabetic retinopathy. Rat primary retinal pericytes were exposed to 25 mmol/l D-glucose for 48 h. Diabetic retinal vessels were prepared from streptozotocin-induced diabetic rats 12 weeks following the induction of diabetes. The expression of HMGB1 was detected using immunofluorescence staining. The expression of RAGE and the activity of NF-κB were analyzed using western blot and electrophoretic mobility shift assays, respectively. The results showed that HMGB1 was translocated to the cytoplasm of the high glucose-treated pericytes and diabetic retinal pericytes, whereas, in the control cells and the normal retinas, HMGB1 was expressed in the cell nuclei only. The expression of RAGE, a potential receptor for HMGB1, and the activity of NF-κB were also increased in the high glucose-treated pericytes, compared with the normal control cells. In addition, high glucose increased the binding of NF-κB to the RAGE promoter. These findings suggested that the cytoplasmic translocation of HMGB1 may be caused by diabetes and high glucose in retinal pericytes, and that the pathogenic role of HMGB1 may be dependent on the expression of RAGE and activation of NF-κB.</P>
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Kim, Junghyun,Kim, Chan-Sik,Sohn, Eunjin,Kim, Jin Sook S. Karger AG 2011 Ophthalmic research Vol.46 No.2
<P>Advanced glycation end products including <I>N</I>ε-(carboxymethyl)lysine (CML) are believed to contribute to retinal pericyte loss in diabetic retinopathy. Nuclear factor-κB (NF-κB) activation has been considered as a potential cytotoxic modulator of retinal pericytes. Herein, we investigated whether CML accumulation can trigger NF-κB activation and apoptosis of retinal pericytes in streptozotocin (STZ)-induced diabetic rats. Seven-week-old Sprague-Dawley rats were made diabetic (STZ, 60 mg/kg). After 5 months, CML level and NF-κB activation were measured in trypsin-digested retinal vessels. In diabetic rats, TUNEL (terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling)-positive and caspase 3-positive retinal pericytes were significantly increased. CML and NF-κB activation was also markedly increased in diabetic retinal vessels. Moreover, the immunoreactivity of NF-κB was localized within the region where CML were accumulated. Apoptosis occurred in CML-accumulating retinal pericytes. These results suggest that NF-κB could be activated in CML-accumulating pericytes from diabetic retina. CML accumulation is responsible, at least in part, for the apoptosis of retinal pericytes.</P><P>Copyright © 2011 S. Karger AG, Basel</P>
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Effect of KIOM-79 on Diabetes-Induced Myocardial Fibrosis in Zucker Diabetic Fatty Rats
Kim, Junghyun,Sohn, Eunjin,Kim, Chan-Sik,Lee, Yun Mi,Jo, Kyuhyung,Kim, Jin Sook Hindawi Publishing Corporation 2013 Evidence-based Complementary and Alternative Medic Vol.2013 No.-
<P>KIOM-79, a herbal mixture of parched Puerariae radix, gingered Magnoliae cortex, Glycyrrhizae radix, and Euphorbiae radix, has a strong inhibitory effect on advanced glycation end products (AGEs) formation. We investigated the beneficial effects of KIOM-79 on cardiac fibrosis in Zucker diabetic fatty (ZDF) rats. KIOM-79 (50 or 500 mg/kg/day) was orally administered for 13 weeks. AGEs formation and collagen expression in the myocardium were assessed by immunohistochemistry. The expression levels of the receptor for AGEs (RAGE), transforming growth factor-<I><I>β</I></I>1 (TGF-<I><I>β</I></I>1), collagen IV, fibronectin, urotensin II, and urotensin II receptor were examined in the myocardial tissue of ZDF rats. KIOM-79 treatment at 500 mg/kg inhibited the accumulation of AGEs, reduced RAGE mRNA and protein expression, and reduced the upregulation of cardiac fibrogenic factors, such as fibronectin and collagen IV, in heart of ZDF rats. Additionally, KIOM-79 ameliorated urotensin II/receptor gene expression in the cardiac tissue of ZDF rats. Our findings indicate that KIOM-79 diminishes cardiac fibrosis in ZDF rats by preventing AGEs accumulation and RAGE overexpression and by modulating the cardiac urotensin II/receptor pathway, which decreases the amount of profibrotic factors, such as TGF-<I><I>β</I></I>1, fibronectin, and collagen in cardiac tissue.</P>
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Extract of Litsea japonica ameliorates blood-retinal barrier breakdown in db/db mice.
Kim, Junghyun,Kim, Chan-Sik,Lee, Ik Soo,Lee, Yun Mi,Sohn, Eunjin,Jo, Kyuhyung,Kim, Joo Hwan,Kim, Jin Sook Macmillan Press 2014 Endocrine Vol.46 No.3
<P>Loss of blood-retinal barrier (BRB) properties is an important feature in the pathology of diabetic retinopathy. Endothelium integrity is important for the normal vascular function. Litsea japonica (Thunb.) Jussieu is a Korean native plant that is consumed as a vegetable food. In this study, we evaluated the ability of an ethanol extract of L. japonica to prevent retinal vascular leakages in db/db mice, which is an animal model of type II diabetes. L. japonica extracts (LJE, 100 and 250 mg/kg) were administered once a day, orally, for 12 weeks. Vehicle-treated db/db mice exhibited hyperglycemia and retinal vascular leakage. LJE treatment blocked diabetes-induced BRB breakdown and decreased retinal VEGF expression in db/db mice. LJE also inhibited the degradation of occludin, which is an important tight junction protein. These findings support the potential therapeutic usefulness of L. japonica for retinal vascular permeability diseases.</P>
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Subsequent platinum based re-treatment of platinum-resistant ovarian cancer: 7 cases review
( Junghyun Kim ),( Jina Yun ),( Ah Reum Chun ),( Se Hun Kim ),( Se Hyung Kim ),( Seong Kyu Park ),( Dae Sik Hong ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1
Patients who relapse within 6 months after completion of therapy are thought to be “platinum-resistant"(Pt-R) and felt to have a worse prognosis. Currently, Single agent such as topotecan, liposomal doxorubicin, vinorelbine, docetaxel and gemcitabine is used as second line setting for patients with Pt-R ovarian cancer. But, some articles have been reported that patients who have Pt-R ovarian cancer may still benefit from re-treatment with platinum compounds after an interval of treatment with nonplatinum agents. The purpose of our study was to review our experience with subsequent platinum based re-treatment in women with Pt-R ovarian cancer. We studied seven patients who had relapsed within six months of their recent exposure to platinum. They were treated with platinum based combination with topotecan, irinotecan, or docetaxel. The median age was 52 years, six patients was received paclitaxel and carboplatin combination chemotherapy prior to re treatment with platinum compounds. They received a median number of six cycles as first line chemotherapy. Two patients achieved complete respons (CR) and 5 had stable disease(SD). The median time to progression(TTP) of 1st line treatment was 8.5 months (95% CI 7.8-9.3) and the median platinum free interval was 4.6 months. All of them had good performance status(ECOG 0) before 2nd line treatment. Four patients received docetaxel-carboplatin and 3 had topotecan/irinotecan-cisplatin combination regimen. A median number of 6 cycles as re treatment with platinum compounds was received. One patient achieved CR, one patient achieved partial response, while 5 patients achieved SD. The median TTP for these seven patients after re-treatment with platinum compounds was 7.3 months (95% CI 5.1-9.4). Four patients had progressive disease and received further salvage therapy with another regimen. The median overall survival from the time deemed to be Pt-R is 22.8 months (95% CI 18.8-26.8). Our small retrospective series suggest that the Pt-R category is still less clear. Patients who have been deemed Pt-R may still benefit from subsequent platinum based re-treatment.
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Kim, Junghyun,Kim, Chan-Sik,Sohn, Eunjin,Lee, Yun Mi,Jo, Kyuhyung,Kim, Jin Sook Hindawi Publishing Corporation 2015 Evidence-based Complementary and Alternative Medic Vol.2015 No.-
<P>Aldose reductase (AR) is the first and rate-limiting enzyme of the polyol pathway. AR-dependent synthesis of excess polyols leads to lens opacification in diabetic cataract. The purpose of this study is to investigate the protective effect of <I>Litsea japonica</I> extract (LJE) on diabetes-induced lens opacification and its protective mechanism in db/db mice. Seven-week-old male db/db mice were treated with LJE (100 and 250 mg/kg body weight) once a day orally for 12 weeks. LJE dose dependently inhibited rat lens aldose reductase activity <I>in vitro</I> (IC<SUB>50</SUB> = 13.53 ± 0.74 <I>µ</I>g/mL). In db/db mice, lens was slightly opacified, and lens fiber cells were swollen and ruptured. In addition, lenticular sorbitol accumulation was increased in db/db mice. However, the administration of LJE inhibited these lenticular sorbitol accumulation and lens architectural changes in db/db mice. Our results suggest that LJE might be beneficial for the treatment of diabetes-induced lens opacification. The ability of LJE to suppress lenticular sorbitol accumulation may be mediated by the inhibition of AR activity.</P>
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