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Kim, Jong Hyun,Park, Bo Gi,Kim, Suel-Kee,Lee, Dong-Hyun,Lee, Gyung Gyu,Kim, Deok-Ho,Choi, Byung-Ok,Lee, Kyu Back,Kim, Jong-Hoon Elsevier 2019 Acta Biomaterialia: structure-property-function re Vol.95 No.-
<P><B>Abstract</B></P> <P>Bioengineering approaches to regulate stem cell fates aim to recapitulate the <I>in vivo</I> microenvironment. In recent years, manipulating the micro- and nano-scale topography of the stem cell niche has gained considerable interest for the purposes of controlling extrinsic mechanical cues to regulate stem cell fate and behavior <I>in vitro</I>. Here, we established an optimal nanotopographical system to improve 3-dimensional (3D) differentiation of pancreatic cells from human pluripotent stem cells (hPSCs) by testing gradient-pattern chips of nano-scale polystyrene surface structures with varying sizes and shapes. The optimal conditions for 3D differentiation of pancreatic cells were identified by assessing the expression of developmental regulators that are required for pancreatic islet development and maturation. Our results showed that the gradient chip of pore-part 2 (Po-2, 200–300 nm diameter) pattern was the most efficient setting to generate clusters of pancreatic endocrine progenitors (PDX1+ and NGN3+) compared to those of other pore diameters (Po-1, 100–200 or Po-3, 300–400 nm) tested across a range of pillar patterns and flat surfaces. Furthermore, the Po-2 gradient pattern-derived clusters generated islet-like 3D spheroids and tested positive for the zinc-chelating dye dithizone. The spheroids consisted of more than 30% CD200 + endocrine cells and also expressed NKX6.1 and NKX2.2. In addition, pancreatic β- cells expressing insulin and polyhormonal cells expressing both insulin and glucagon were obtained at the final stage of pancreatic differentiation. In conclusion, our data suggest that an optimal topographical structure for differentiation to specific cell types from hPSCs can be tested efficiently by using gradient-pattern chips designed with varying sizes and surfaces.</P> <P><B>Statement of Significance</B></P> <P>Our study provides demonstrates of using gradient nanopatterned chips for differentiation of pancreatic islet-like clusters.</P> <P>Gradient nanopatterned chips are consisted of two different shapes (nanopillar and nanopore) in three different ranges of nano sizes (100–200, 200–300, 300–400 nm). We found that optimal nanostructures for differentiation of pancreatic islet-like clusters were 200–300 nm nano pores.</P> <P>Cell transplantation is one of the major therapeutic option for type 1 diabetes mellitus (DM) using stem cell-derived β-like cells. We generated 50 um pancreatic islet-like clusters in size, which would be an optimal size for cell transplantation. Futuremore, the small clusters provide a powerful source for cell therapy.</P> <P>Our findings suggest gradient nanopatterned chip provides a powerful tool to generate specific functional cell types of a high purity for potential uses in cell therapy development.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Kim, Kee-Young,Osabutey, Angelina F.,Nguyen, Phuong,Kim, Soo Bae,Jo, You-Young,Kweon, HaeYong,Lee, Hyun-Tai,Ji, Sang-Deok,Koh, Young Ho Korean Society of Sericultural Science 2019 International Journal of Industrial Entomology Vol.39 No.1
Steamed and freeze-dried mature silkworm powder (SMSP) is a natural food containing a large amount of various functional materials and has various health promoting effects. SMSP is known to increase the life expectancy and healthspan, simultaneously. The accomplishment of extension of healthspan should be possible to achieve by activating various signaling pathways delaying aging in various tissues, not by regulating only a few signaling pathways. Consistent with this notion, SMSP increased the resistant to Parkinson disease by enhancing olfaction and mitochondrial activity in neurons of animal models. In addition, SMSP could enhance the gastrointestinal functions. The animals consumed SMSP showed enhanced alcohol metabolisms, reduced cholesterols in bloods, increased resistance to carcinogens causing liver cancers, and protective effects in alcohol induced stomach ulcers. Furthermore, SMSP was also effective in appearance. The SMSP consumed animals showed reduced skin pigmentations and more hair growth compared with control animals. Taken together, the functional enhancement effects of SMSPs in various tissues and organs, which have been discovered to date, are combined to extend healthspan. Therefore, SMSP can be regarded as calorie restriction mimetics. Further studies in the health promoting effects of SMSP will contribute to identifying new applicable diseases, resulted in increased sales of SMSP and incomes of sericulture farmers.
Kim, Dae-Seung,Kim, Sung-Hee,Kee, Ji-Ye,Han, Yo-Han,Park, JinBong,Mun, Jeong-Geon,Joo, Moon-Jung,Jeon, Yong-Deok,Kim, Su-Jin,Park, Sang-Hyun,Park, Sung-Joo,Um, Jae-Young,Hong, Seung-Heon Institute for Advanced Research in Asian Science a 2017 The American journal of Chinese medicine Vol. No.
<P><I>Eclipta prostrata</I> (EP) and its compounds are known to have several pharmacological effects including anti-inflammatory effects. In the present study, we demonstrated that EP improves the dextran sulfate sodium (DSS)-induced colitis symptoms such as body weight loss, colon length shortening and disease activity index. In DSS-induced colitis tissue, EP controls the protein expressions of cyclooxygenase-2 (COX-2) and hypoxia inducible factor-1<TEX>$ \alpha $</TEX> (HIF-1<TEX>$ \alpha $</TEX>). In addition, the release of prostaglandin E<SUB>2</SUB> and vascular endothelial growth factor-A were significantly reduced by EP administration. EP also inhibited COX-2 and HIF-1<TEX>$ \alpha $</TEX> expressions in the tumor necrosis factor-<TEX>$ \alpha $</TEX> stimulated HT-29 cells. These inhibitory effects of EP occurred by reducing the phosphorylation of I<TEX>$ \kappa $</TEX>B and the translocation of the nuclear factor-<TEX>$ \kappa $</TEX>B (NF-<TEX>$ \kappa $</TEX>B). Additionally, we found through HPLC analysis that wedelolactone, which is an inhibitor of NF-<TEX>$ \kappa $</TEX>B transcription, was contained in water extract of EP. These results indicate that EP can improve colitis symptoms through the modulation of immune function in intestinal epithelial cells and suggests that EP has the potential therapeutic effect to intestinal inflammation.</P>
Microsatellite Analysis of the Silkworm Strains (Bombyx mori) Originated from China
Kim, Kee-Young,Kang, Pil-Don,Ryu, Kang-Sun,Kim, Ki-Hwan,Sung, Gyoo-Byung,Ji, Sang-Deok,Kim, Mi-Ja,Kim, Ik-Soo Korean Society of Sericultural Science 2012 International Journal of Industrial Entomology Vol.25 No.1
A total of 85 Chinese-origin silkworm strains preserved in Korea were genotyped for eight polymorphic micro-satellite loci. We obtained per-locus number of alleles, ranging from 5 to 14 with an average value of 9.5, perlocus observed heterozygosity, ranging from 0.07 to 0.99, and per-locus polymorphic information content (PIC), ranging from 0.34 to 0.82, indicating that some loci are highly variable. Phylogenetic analysis with the eight concatenated microsatellite loci showed no clustering on the basis of known strain characteristics. A total of 22 strain-specific apomorphic alleles, which discriminate 19 among 85 silkworm strains were obtained from eight loci. These strain-specific alleles, thus, can casually be utilized for the discrimination of applicable strains without any further typing of other loci. Furthermore, a substantial number of homozygote strains, represented by 27 among 76 alleles in eight loci were found. These results collectively suggest that the silkworm microsatellite DNA is actually and potentially important molecular markers for the eventual discrimination of silkworm strains that are preserved as hundreds in Korea.
Kim, You Song,Chun, Byong Sun,Kim, Deok-kee,Hwang, Jae Yeon,Kim, Soon Sub,Rhee, J.R.,Kim, Keewon,Kim, Taewan,Kim, Young Keun IEEE 2006 IEEE transactions on magnetics Vol.42 No.10
The typical double-barrier magnetic tunnel junction (DMTJ) structure examined in this paper consists of a Ta 45/Ru 9.5/IrMn 10/CoFe 7/AlO<SUB>x</SUB>/free layer/AlO<SUB>x</SUB>/CoFe 7/IrMn 10/Ru 60 (nm). The free layer consists of an Ni<SUB>16</SUB>Fe<SUB>62</SUB>Si<SUB>8</SUB>B<SUB>14</SUB> 7 nm, Co<SUB>90</SUB>Fe<SUB>10</SUB> (fcc) 7 nm, or CoFe t<SUB>1</SUB>/NiFeSiB t<SUB>2</SUB>/CoFe t<SUB>1</SUB> layer in which the thicknesses t<SUB>1</SUB> and t<SUB>2</SUB> are varied. The DMTJ with an NiFeSiB-free layer had a tunneling magnetoresistance (TMR) of 28%, an area-resistance product (RA) of 86 k Ω μm<SUP>2</SUP>, a coercivity (H<SUB>c</SUB>) of 11 Oe, and an interlayer coupling field (H<SUB>i</SUB>) of 20 Oe. To improve the TMR ratio and RA, a DMTJ comprising an amorphous NiFeSiB layer that could partially substitute for the CoFe free layer was investigated. This hybrid DMTJ had a TMR of 30%, an RA of 68 k Ωμ m<SUP>2</SUP>, and a H<SUB>c</SUB> of 11 Oe, but an increased H<SUB>i</SUB> of 37 Oe. We confirmed by atomic force microscopy and transmission electron microscopy that H<SUB>i</SUB> increased as the thickness of NiFeSiB decreased. When the amorphous NiFeSiB layer was thick, it was effective in retarding the columnar growth which usually induces a wavy interface. However, if the NiFeSiB layer was thin, the roughness was increased and H<SUB>i</SUB> became large because of the magnetostatic Ne´el coupling.
Ag back electrode bonding process for inverted organic solar cells
Kim, Honggyun,Kumar, Sandeep,Kim, Og Jin,Iyer, S. Sundar Kumar,Kim, Deok-kee Elsevier 2019 Journal of alloys and compounds Vol.777 No.-
<P><B>Abstract</B></P> <P>A new style of forming Ag back electrode for organic solar cells (OSCs) using a bonding process was compared with a conventional screen-printed <I>Ag</I>. All the fabrication process steps have been conducted under atmospheric conditions at room temperature without using a glove box. The OSCs with both screen-printed and bonded Ag back electrode exhibited comparable performances with the average power conversion efficiencies of 1.28% and 1.31%, respectively. The series and the shunt resistance values for the OSC with the bonded Ag were slightly better than those with the screen printed Ag. The binder resin at the interface between the PEDOT:PSS and the Ag may increase contact resistance for the screen-printed Ag process, while that between the Ag and the PET film for the bonded Ag process may not increase it. The bonding process for the Ag back electrode has the potential for future electronic device applications.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A new style of forming Ag back electrode using a bonding process is proposed. </LI> <LI> All the process steps are conducted under atmospheric conditions at room temperature. </LI> <LI> The bonded Ag back electrode exhibited a comparable average performance. </LI> <LI> The binder resin for the bonded Ag process may not increase the series resistance. </LI> <LI> The bonding process forms an encapsulation simultaneously for protection. </LI> </UL> </P>
Kim, Hyun-Soo,Sim, Eun Deok,Kim, Jong-hoi,Kwon, Oh Kee,Kim, Kang Ho,Oh, Kwang-Ryong Institute of Physics 2006 Semiconductor science and technology Vol.21 No.10
<P>All-optical wavelength conversion at 10 Gb s<SUP>−1</SUP> is demonstrated in a Mach–Zehnder interferometric wavelength converter (MZI-WC) module with monolithically integrated SOA preamplifiers and tapered-edge multimode interference couplers (TMMIs). A conventional buried-type 1 × 2 MMI coupler exhibits a minimal excess loss of 0.43 dB and a reflectivity of 5.1 × 10<SUP>−4</SUP> (<I>L</I><SUB>MMI</SUB> = 172 µm, <I>W</I><SUB>MMI</SUB> = 12 µm). We adapt the 1 × 2 TMMI in the MZI-WC to improve back-reflection and poor uniformity, which is a major problem of conventional MMI and Y-branch. A good performance of the MZI-WC monolithically integrated with TMMI and SOA preamplifiers at 10 Gb s<SUP>−1</SUP> is obtained with clear eye patterns, and a power penalty below 1.5 dB at a 10<SUP>−9</SUP> bit error rate over the whole C band (45 nm span) is obtained. The dynamic input power range is enhanced up to 11.3 dB by adjusting only the injection current of the SOA preamplifier.</P>
Effect of pulverizing method on the particle size of matured silkworm powder
Kim, Su-Bae,Kim, Kee-Young,Ji, Sang-Deok,Kim, Seong-Wan,Kim, Nam-Suk,Jo, You-Young,Kim, Jong-Gil,Kim, Young-Guk,Koo, Hui-Yeon,Moon, Hyung-Chul,Seok, Young-Seek,Lee, Hyun-Tai Korean Society of Sericultural Science 2018 International Journal of Industrial Entomology Vol.37 No.2
Recently matured silkworm powder was developed by RDA. In this study, the effect of pulverizing method on the particle size of matured silkworm powder was examined. FESEM was performed to observe the morphology and to measure the particle size of silkworm powder. Particle morphology of air-jet mill pulverized powder was round and smooth, however, those of roller-mill and hammer-mill pulverized mature silkworm was more harsh and square. Particle size was varied with pulverizing technique as follows; $1.1{\mu}m$ (air-jet mill), $10{\mu}m$ (roller mill), and $120{\mu}m$ (hammer mill), respectively. A proximate analysis results of air-jet mill powder showed that crude protein, crude lipid, crude fiber, and ash was 73%, 12%, 1.95%, and 3.4%, respectively. According to our results, air-jet mell technique might be used to make a tiny matured silkworm powder.