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Transcriptional regulation of KRAB-ZFPs in cancer
Key-Hwan Lim,Sang Gyu Park,Sang Gyu Park 대한독성 유전단백체 학회 2015 Molecular & cellular toxicology Vol.11 No.4
Many studies have focused on how cellular transcription factors (TFs) regulate gene transcription. Evidence suggests that activation or repression of a variety of genes are the result of conflicting positive and negative regulatory TFs. KRAB (Kruppel-associated box)-ZFPs (zinc-finger proteins) constitute a massive family of tetrapod-specific transcription repressors that have pivotal roles in cellular processes, including differentiation, proliferation, migration, apoptosis, and inflammation. Because a large number of KRAB-ZFPs are identified in higher vertebrates, it is a well-understood member of the transcription system. Even though the function of KRAB-ZFPs has been identified, unraveling its specific role in cancer is still a challenge. In addition to its major activity in transcription repression, however, some of its families have the opposite function of target gene activation. Here, we review the current understanding of how KRAB-ZFPs are associated with cancer, and discuss the mechanism that regulates transcriptional activation or repression of target genes.
Jia Ryu,Key Hwan Lim,Dong-Ryeol Ryu,Hyang Woon Lee,Ji Young Yun,Seoung-Wook Kim,Ji-Hoon Kim,Kyunghee Jung-choi,Hyunjoo Kim 대한직업환경의학회 2016 대한직업환경의학회지 Vol.28 No.-
Background: Methyl alcohol poisoning has been mainly reported in community. Two cases of methyl alcohol poisoning occurred in a small-sized subcontracted factory which manufactured smartphone parts in Korea. Case presentation: One young female patient presented with dyspnea and visual disturbance. Another young male patient presented with visual disturbance and myalgia. They treated with sodium bicarbonate infusion and hemodialysis for metabolic acidosis. In addition, he received ethyl alcohol per oral treatment. Her and his urinary methyl alcohol concentration was detected as 7.632 mg/L, 46.8 mg/L, respectively, although they were treated hemodialysis. Results of the working environment measurement showed that the concentration of methyl alcohol (1030.1–2220.5 ppm) in the air exceeded the time weighted average (200 ppm). They were diagnosed with optic neuropathy due to methyl alcohol poisoning and still have visual impairment. Conclusions: Workers who hired as dispatched employees in a small-sized subcontracted factory were exposed to high concentrations of methyl alcohol. The workplace had poor ventilation system. In addition, workers did not wear proper personal protect equipment. Working environment measurement and annual chekups for workers were not performed. They were in a blind spot to occupational safety and health. More attention is needed to protect vulnerable workers’ health.
Ryu, Jia,Lim, Key Hwan,Ryu, Dong-Ryeol,Lee, Hyang Woon,Yun, Ji Young,Kim, Seoung-Wook,Kim, Ji-Hoon,Jung-choi, Kyunghee,Kim, Hyunjoo BioMed Central 2016 Annals of occupational and environmental medicine Vol.28 No.-
<P><B>Background</B></P><P>Methyl alcohol poisoning has been mainly reported in community. Two cases of methyl alcohol poisoning occurred in a small-sized subcontracted factory which manufactured smartphone parts in Korea.</P><P><B>Case presentation</B></P><P>One young female patient presented with dyspnea and visual disturbance. Another young male patient presented with visual disturbance and myalgia. They treated with sodium bicarbonate infusion and hemodialysis for metabolic acidosis. In addition, he received ethyl alcohol per oral treatment. Her and his urinary methyl alcohol concentration was detected as 7.632 mg/L, 46.8 mg/L, respectively, although they were treated hemodialysis. Results of the working environment measurement showed that the concentration of methyl alcohol (1030.1–2220.5 ppm) in the air exceeded the time weighted average (200 ppm). They were diagnosed with optic neuropathy due to methyl alcohol poisoning and still have visual impairment.</P><P><B>Conclusions</B></P><P>Workers who hired as dispatched employees in a small-sized subcontracted factory were exposed to high concentrations of methyl alcohol. The workplace had poor ventilation system. In addition, workers did not wear proper personal protect equipment. Working environment measurement and annual chekups for workers were not performed. They were in a blind spot to occupational safety and health. More attention is needed to protect vulnerable workers’ health.</P>