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RISS 인기검색어
- 검색키워드
- 저자 : Kevin Hines (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
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Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production
Hine, Christopher,Kim, Hyo-Jeong,Zhu, Yan,Harputlugil, Eylul,Longchamp, Alban,Matos, Marina Souza,Ramadoss, Preeti,Bauerle, Kevin,Brace, Lear,Asara, John M.,Ozaki, C. Keith,Cheng, Sheue-yann,Singha, S Cell Press 2017 Cell metabolism Vol.25 No.6
<▼1><P><B>Summary</B></P><P>Decreased growth hormone (GH) and thyroid hormone (TH) signaling are associated with longevity and metabolic fitness. The mechanisms underlying these benefits are poorly understood, but may overlap with those of dietary restriction (DR), which imparts similar benefits. Recently we discovered that hydrogen sulfide (H<SUB>2</SUB>S) is increased upon DR and plays an essential role in mediating DR benefits across evolutionary boundaries. Here we found increased hepatic H<SUB>2</SUB>S production in long-lived mouse strains of reduced GH and/or TH action, and in a cell-autonomous manner upon serum withdrawal in vitro. Negative regulation of hepatic H<SUB>2</SUB>S production by GH and TH was additive and occurred via distinct mechanisms, namely direct transcriptional repression of the H<SUB>2</SUB>S-producing enzyme cystathionine γ-lyase (CGL) by TH, and substrate-level control of H<SUB>2</SUB>S production by GH. Mice lacking CGL failed to downregulate systemic T<SUB>4</SUB> metabolism and circulating IGF-1, revealing an essential role for H<SUB>2</SUB>S in the regulation of key longevity-associated hormones.</P></▼1><▼2><P><B>Highlights</B></P><P>•<P>Hepatic H<SUB>2</SUB>S production capacity is elevated in long-lived hypopituitary mouse models</P>•<P>Growth hormone (GH) represses hepatic H<SUB>2</SUB>S production post-transcriptionally</P>•<P>Thyroid hormone (TH) acts via TRβ to repress cystathionine γ-lyase and H<SUB>2</SUB>S levels</P>•<P>H<SUB>2</SUB>S negatively regulates circulating TH and IGF-1 levels</P></P></▼2><▼3><P>Reduced thyroid hormone (TH) and growth hormone (GH) activity are hallmarks of genetic models of longevity in mice. Here, Hine et al. find that TH and GH negatively regulate hepatic production of the longevity-associated gas hydrogen sulfide, which feeds back to negatively regulate circulating TH and IGF-1 levels.</P></▼3>
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Are Lumbar Fusion Guidelines Followed? A Survey of North American Spine Surgeons
Thiago S. Montenegro,Christopher Elia,Kevin Hines,Zorica Buser,Jefferson Wilson,Zoher Ghogawala,Shekar N. Kurpad,Daniel M. Sciubba,James S. Harrop 대한척추신경외과학회 2021 Neurospine Vol.18 No.2
Objective: To evaluate the use of guidelines for lumbar spine fusions among spine surgeons in North America. Methods: An anonymous survey was electronically sent to all AO Spine North America members. Survey respondents were asked to indicate their opinion surrounding the suitability of instrumented fusion in a variety of clinical scenarios. Fusion indications in accordance with North America Spine Society (NASS) guidelines for lumbar fusion were considered NASS-concordant answers. Respondents were considered to have a NASS-concordant approach if ≥70% (13 of 18) of their answers were NASS-concordant answers. Comparisons were performed using bivariable statistics. Results: A total of 105 responses were entered with complete data available on 70. Sixty percent of the respondents (n=42) were considered compliant with NASS guidelines. NASS-discordant responses did not differ between surgeons who stated that they include the NASS guidelines in their decision-making algorithm (5.10±1.96) and those that did not (4.68± 2.09) (p=0.395). The greatest number of NASS-discordant answers in the United States. was in the South (5.75±2.09), with the lowest number in the Northeast (3.84±1.70) (p< 0.01). For 5 survey items, rates of NASS-discordant answers were ≥40%, with the greatest number of NASS-discordant responses observed in relation to indications for fusion in spinal deformity (80%). Spine surgeons utilizing a NASS-concordant approach had a significant lower number of NASS-discordant answers for synovial cysts (p=0.03), axial low back pain (p<0.01), adjacent level disease (p<0.01), recurrent stenosis (p<0.01), recurrent disc herniation (p=0.01), and foraminal stenosis (p<0.01). Conclusion: This study serves an important role in clarifying the rates of uptake of clinical practice guidelines in spine surgery as well as to identify barriers to their implementation.
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