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Clinical characteristics of inflammatory bowel disease patients with immunoglobulin A nephropathy
( Ryohei Hayashi ),( Yoshitaka Ueno ),( Shinji Tanaka ),( Kana Onishi ),( Takeshi Takasago ),( Masaki Wakai ),( Toshikatsu Naito ),( Kensuke Sasaki ),( Shigehiro Doi ),( Takao Masaki ),( Kazuaki Chaya 대한장연구학회 2021 Intestinal Research Vol.19 No.4
Background/Aims: Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract. Some patients with this condition have been reported to present with immunoglobulin A nephropathy (IgAN), a renal complication that can cause end-stage renal failure, but the frequency of this comorbidity has not been described. Thus, the aim of this study was to investigate the frequency of IgAN in patients with IBD. Methods: This study included 620 patients with IBD (338 with ulcer-ative colitis [UC] and 282 with Crohn’s disease [CD]) from the Hiroshima University Hospital outpatient department. IgAN cases were identified from medical interviews, blood examinations (serum immunoglobulin A), and urinalyses (occult blood, proteinuria). Definitive IgAN cases were diagnosed by renal biopsies, while those detected through the clinical course and test results, but not clinically recommended for renal biopsy, were defined as suspected IgAN. Results: We analyzed 427 cases meeting the inclusion criteria (220 with UC and 207 with CD). The incidence of IgAN across all patients with IBD was 3.0%. The frequency of IgAN was significantly higher in patients with CD (11/207, 5.3%) than in those with UC (2/220, 0.9%) (P< 0.01). Moreover, a significant correlation was found between CD patients with ileostomy or colostomy and a diagnosis of IgAN. Con-clusions: Patients with IBD present a high incidence of IgAN, especially those with CD who have undergone ileostomy or co-lostomy. (Intest Res 2021;19:430-437)
Visualization of multi-dimensional living body information based on wavelet transformation analysis
Toru Yamamoto,Kensuke Hayashi,Seiichi Shin 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
This paper proposes a new visualizing method for analyzing a pulse caused by a heart beat signal from a car seat. The pulse signal is measured by piezoelectric sensors in the seat, in order to analyze characteristic frequency of the pulse with wavelet transform. It is needed a method for visualization of these signals based on the wavelet transform although there are 18 channels with different delays and measured signals are contaminated by noise. An experiment result shows effectiveness of the proposing method.
The Aqua-Planet Experiment (APE): Response to Changed Meridional SST Profile
WILLIAMSON, David L.,BLACKBURN, Michael,NAKAJIMA, Kensuke,OHFUCHI, Wataru,TAKAHASHI, Yoshiyuki O.,HAYASHI, Yoshi-Yuki,NAKAMURA, Hisashi,ISHIWATARI, Masaki,McGREGOR, John L.,BORTH, Hartmut,WIRTH, Volkm Meteorological Society of Japan 2013 Journal of the Meteorological Society of Japan Vol.a91 No.-
The Aqua-Planet Experiment (APE): CONTROL SST Simulation
BLACKBURN, Michael,WILLIAMSON, David L.,NAKAJIMA, Kensuke,OHFUCHI, Wataru,TAKAHASHI, Yoshiyuki O.,HAYASHI, Yoshi-Yuki,NAKAMURA, Hisashi,ISHIWATARI, Masaki,McGREGOR, John L.,BORTH, Hartmut,WIRTH, Volkm Meteorological Society of Japan 2013 Journal of the Meteorological Society of Japan Vol.a91 No.-
Michihiro Iwaki,Hideki Fujii,Hideki Hayashi,Hidenori Toyoda,Satoshi Oeda,Hideyuki Hyogo,Miwa Kawanaka,Asahiro Morishita,Kensuke Munekage,Kazuhito Kawata,Tsubasa Tsutsumi,Koji Sawada,Tatsuji Maeshiro,H 대한간학회 2024 Clinical and Molecular Hepatology(대한간학회지) Vol.30 No.2
Background/Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) was recently proposed as an alternative disease concept to nonalcoholic fatty liver disease (NAFLD). We aimed to investigate the prognosis of patients with biopsy-confirmed MASLD using data from a multicenter study. Methods: This was a sub-analysis of the Clinical Outcome Nonalcoholic Fatty Liver Disease (CLIONE) study that included 1,398 patients with NAFLD. Liver biopsy specimens were pathologically diagnosed and histologically scored using the NASH Clinical Research Network system, the FLIP algorithm, and the SAF score. Patients who met at least one cardiometabolic criterion were diagnosed with MASLD. Results: Approximately 99% of cases (n=1,381) were classified as MASLD. Patients with no cardiometabolic risk (n=17) had a significantly lower BMI than patients with MASLD (20.9 kg/m2 vs. 28.0 kg/m2, P<0.001), in addition to significantly lower levels of inflammation, ballooning, NAFLD activity score, and fibrosis stage based on liver histology. These 17 patients had a median follow-up of 5.9 years, equivalent to 115 person-years, with no deaths, liver-related events, cardiovascular events, or extrahepatic cancers. The results showed that the prognosis for pure MASLD was similar to that for the original CLIONE cohort, with 47 deaths and one patient who underwent orthotopic liver transplantation. The leading cause of death was extrahepatic cancer (n=10), while the leading causes of liver-related death were liver failure (n=9), hepatocellular carcinoma (n=8), and cholangiocarcinoma (n=4). Conclusions: Approximately 99% of NAFLD cases were considered MASLD based on the 2023 liver disease nomenclature. The NAFLD-only group, which is not encompassed by MASLD, had a relatively mild histopathologic severity and a favorable prognosis. Consequently, the prognosis of MASLD is similar to that previously reported for NAFLD.