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Enomoto, Akiko,Itoh, Ken,Harada, Takanori,Yamamoto, Masayuki The Korean Society of Toxicology Korea Environment 2001 Toxicological Research Vol.17 No.-
Xenobiotics and their reactive intermediates bind to cellular macromolecules and/or generate oxidative stress. which provoke deleterious effects on the cell function. Induction of xenobiotic-biotrans-forming enzymes and antioxidant molecules is an important defense mechanism against such insults. A group of genes involved in the defense mechanism. e.g. genes encoding glutathione S-transferases. NAD(P)H: quinone oxidoreductase, UDP-glucuronosyltransferase (UDP-GT) and ${\gamma}$-glutamylcysteine synthetase (GGCS). have a common regulatory sequence, Antioxidant or Electrophile Responsive Element (ARE/EpRE). Recently. Nrf2. discovered as a homologue of erythroid transcription factor p45 NF-E2, was shown to bind ARE/EpRE and induce the expression of these defense genes. Mice that lack Nrf2 show low basal levels of expression and/or impaired induction of these genes. which makes the animals highly sensitive to xenobiotic toxicity. Indeed. we show here that nrf2-deficient mice had a higher mortality than did the wild-type mice when exposed to acetaminophen (APAP). Detailed analyses of APAP hepatotoxicity in the nrf2 knockout mice indicate that a large amount of reactive APAP metabolites was generated in the livers due to the impaired basal expression of two detoxifying enzyme genes, UDP-GT (Ugt1a6) and GGCS. while the cytochrome P450 content was unchanged. Thus. the studies using the nrf2 knockout mice clearly demonstrate significance of the expression of Nrf2-regulated enzymes in protection against xenobiotic toxicity.
Naohisa Yoshida,Osamu Dohi,Ken Inoue,Ritsu Yasuda,Takaaki Murakami,Ryohei Hirose,Ken Inoue,Yuji Naito,Yutaka Inada,Kiyoshi Ogiso,Yukiko Morinaga,Mitsuo Kishimoto,Rafiz Abdul Rani,Yoshito Itoh 거트앤리버 소화기연관학회협의회 2019 Gut and Liver Vol.13 No.2
A laser endoscopy system was developed in 2012. The system allows blue laser imaging (BLI), BLI-bright, and linked color imaging (LCI) to be performed as modes of narrowband light observation; these modes have been reported to be useful for tumor detection and characterization. Furthermore, an innovative endoscopy system using four-light emitting diode (LED) multilight technology was released in 2016 to 2017 in some areas in which laser endoscopes have not been approved for use, including the United States and Europe. This system enables blue light imaging (this is also known as BLI) and LCI with an LED light source instead of a laser light source. Several reports have shown that these modes have improved tumor detection. In this paper, we review the efficacy of BLI and LCI with laser and LED endoscopes in tumor detection and characterization.
Michiko Tsushima,Jun Liu,Wataru Hirao,Hiromi Yamazaki,Hirofumi Tomita,Ken Itoh 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.3
Nrf2 regulates redox homeostasis in cells bycoordinately regulating a range of antioxidant enzymes andproteins. An increase in oxidative stress is one of the hallmarksof aging, and Nrf2 protein levels and activity decreasewith aging. Decreased mitochondrial functions, such asdecreased ATP production, also occur with aging, leadingto the increased generation of reactive oxygen species (ROS)and oxidative stress. Thus, understanding the relationshipsbetween Nrf2 and the mitochondria is important for clarifyingthe regulatory mechanisms of aging. It is becomingclear that Nrf2 is activated in a tissue-specific manner inresponse to mitochondrial or NADPH oxidase-generatedROS. As the heart consists of postmitotic cells that utilizeATP produced mainly by mitochondrial oxidative phosphorylation,cardiomyocytes are equipped with highly sophisticatedmitochondrial quality control mechanisms. Consistentwith these findings, it has been reported that Nrf2 inthe heart is regulated via a specific translational mechanismand that Nrf2 activation confers cardioprotective effects invarious disease models. Thus, Nrf2 is a promising target foranti-aging strategies to combat age-related heart diseases,such as age-related cardiomyopathy.
Lee, Kyung-Tae,Sohn, Il-Cheol,Kim, Young-Kwan,Chio, Jung-Hye,Choi, Jong-Won,Park, Hee-Juhn,Itoh, Yoshie,Miyamoto, Ken-ichi 경희대학교 경희동서약학연구소 2001 경희약대 논문집 Vol.29 No.-
Cytotoxic effects of six isoflavonoids, tectorigenin, glycitein, tectoridin, glycitin, 6”-O-xylosyltectoridin, and 6”-O-xylosylglycitin isolated from the flower of Pueraria thunberglane BENTH, together with genistein, a known differentiation and apoptosis inducer, were examined. Among these isoflavonoids, Tectorigenin and genistein exhibited cytotoxicity against various human cancer cells; glycitein showed only mild cytotoxicity. These results suggest that the isoflavone structure and S-hydroxyl group are crucial for the cytotoxic properties and that glycosides are inactive. Moreover, tectorigenin induced differentiation of human promyelocytic leukemia HL-60 cells to granulocytes and monocytes/macrophages, and caused apoptotic changes of DNA in the cells, as did genistein. Tectorigenin also inhibited autophosphorylation of epidermal growth factor (EGF) receptor by EGF and decreased the expression of Bel-2 protein, with less activity than genistein. From these results, tectorigenin may be a possible therapeutic agent for leukemia.