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- 저자 : Keigo Suzuki (검색결과 3 건)
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김현,김연옥,홍영진,Keigo Shibayama,Yasuhiko Suzuki,Nobutaka Wakamiya 한국유전학회 2014 Genes & Genomics Vol.36 No.3
Severe acute respiratory syndrome (SARS) iscaused by the SARS coronavirus (CoV). The spike proteinof SARS-CoV consists of S1 and S2 domains, which areresponsible for virus binding and fusion, respectively. Thereceptor-binding domain (RBD) positioned in S1 can specificallybind to angiotensin-converting enzyme 2 (ACE2)on target cells, and ACE2 regulates the balance betweenvasoconstrictors and vasodilators within the heart andkidneys. Here, a recombinant fusion protein containing193-amino acid RBD (residues 318–510) and glutathioneS-transferase were prepared for binding to target cells. Additionally, monoclonal RBD antibodies were preparedto confirm RBD binding to target cells through ACE2. Wefirst confirmed that ACE2 was expressed in various mousecells such as heart, lungs, spleen, liver, intestine, andkidneys using a commercial ACE2 polyclonal antibody. We also confirmed that the mouse fibroblast (NIH3T3) andhuman embryonic kidney cell lines (HEK293) expressedACE2. We finally demonstrated that recombinant RBDbound to ACE2 on these cells using a cellular enzymelinkedimmunosorbent assay and immunoassay. Theseresults can be applied for future research to treat ACE2-related diseases and SARS.
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Daisuke Ide,Tomohiko Richard Ohya,Mitsuaki Ishioka,Yuri Enomoto,Eisuke Nakao,Yuki Mitsuyoshi,Junki Tokura,Keigo Suzuki,Seiichi Yakabi,Chihiro Yasue,Akiko Chino,Masahiro Igarashi,Akio Nakashima,Masayuk 대한소화기내시경학회 2022 Clinical Endoscopy Vol.55 No.5
Background/Aims: Endoscopic submucosal dissection (ESD) for residual or recurrent colorectal lesions after incomplete resection is challenging because of severe fibrosis. This study aimed to compare the efficacy of the pocket-creation method (PCM) with a traction device (TD) with that of conventional ESD for residual or recurrent colorectal lesions. Methods: We retrospectively studied 72 patients with residual or recurrent colorectal lesions resected using ESD. Overall, 31 and 41 le- sions were resected using PCM with TD and conventional ESD methods, respectively. We compared patient background and treatment outcomes between the PCM with TD and conventional ESD groups, respectively. The primary endpoints were en bloc resection and R0 resection rates. The secondary endpoints were the dissection speed and incidence of adverse events. Results: En bloc resection was feasible in all cases with PCM with TD, but failed in 22% of cases of conventional ESD. The R0 resection rates for PCM with TD and conventional ESD were 97% and 66%, respectively. Dissection was significantly faster in the PCM with TD group (13.0 vs. 7.9 mm2/min). Perforation and postoperative bleeding were observed in one patient in each group. Conclusions: PCM with TD is an effective method for treating residual or recurrent colorectal lesions after incomplete resection.
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Yuho Shimizu,Tomoya Takahashi,Kenichiro Sato,Susumu Ogawa,Daisuke Cho,Yoshifumi Takahashi,Daichi Yamashiro,Yan Li,Keigo Hinakura,Ai Iizuka,Tomoki Furuya,Hiroyuki Suzuki 질병관리본부 2023 Osong Public Health and Research Persptectives Vol.14 No.5
Objectives: As the population ages worldwide, including in Japan, there is a growing expectation for older adults to remain active participants in society. The act of sharing one’s experiences and knowledge with younger generations through social engagement not only enriches the lives of older individuals, but also holds significant value for our society. In this study, we examined both positive and negative perceptions of older adults and investigated the correlation between these perceptions and generativity among older citizens. Additionally, we evaluated the impact of life satisfaction on these factors. Methods: We conducted a survey of 100 older adults in Japan (mean age, 71.68 years) and utilized multiple regression analyses, using positive and negative perceptions of older adults, life satisfaction, and demographic factors as independent variables. The sub-categories of generativity—namely, generative action, concern, and accomplishment—were used as dependent variables. Results: Participants who held a more positive perception of older adults demonstrated a higher level of generative actions and concerns. Additionally, participants who reported higher levels of life satisfaction also exhibited more generative actions, concerns, and accomplishments. Conversely, those who held a more negative perception of older adults were found to have higher levels of generative actions. Conclusion: Enhancing positive perceptions of older adults among them can boost the sub-categories of generativity. This study, which was conducted from an exploratory perspective, has several limitations, including a potential sampling bias. A more comprehensive examination of the relationship between perceptions of older adults and generativity is anticipated in future research.
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