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Nerophysiological Mechanisms of Acupuncture Analgesia
Kazuo Toda 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1
Kazuo Toda. Department of Physiology, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8549, Japan. Nerophysiological Mechanisms of Acupuncture Analgesia. Proceedings of International Symposium on East-West Medicine, Seoul. 27-35,1999.-Acupuncture stimulation evokes powerful analgesic feeects in various species of animals and in man. It is important to know which peripheral nerves convey the acupuncture information for producing analgesic effects. In addition, as one of the specific action of the acupuncture, it has been reported that maximunm effects are produced some time after the onset of the stimulation and the effects still remains after the cessation of its stimulation. Above-mentioned specific action, which is usually sustained for some minutes or even some days, may not be explained by simple inhibitory neural mechanisms. Therefore, it has been proposed that the acupuncture effects are elicited by the activation of the endogenous oioid system. However, a clear mechanism of analgesic effects induced by acupuncture is still nuknown. The present speech shows the summary of the recent studies about peripheral and central mechanisms of acupuncture-induced antinociceptive effects obtained mainly from rat experimets. The main topics are as follows: 1. Characteristics of meridian points 2. Afferentnerve information evoked by acupuncture stimulation 3. Inhibitory mechanisms in the CNS 4. Endogenous antinocicptive substances concerned with acupuncture analgesia 5. Descending antinociceptive effects
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Age Differences in Naloxone Reversibility of Electroacupuncture on the Jaw Opening Reflex in Rats
Hiromi Yamashita,Jorge Luis Lopes Zeredo,Kazuo Toda 사단법인약침학회 2021 Journal of Acupuncture & Meridian Studies Vol.14 No.4
Background: Electroacupuncture is one of the most popular physical treatments for clinical pain, but the potential influence of a patient’s age on the effectiveness of electro acupuncture treatment has not been clearly established. Objectives: The present study aimed to detect a potential difference in electroacu puncture-induced analgesia between juvenile and adult rats. Methods: In this study, we investigated the effects of electroacupuncture treatment on the nociceptive jaw-opening reflex evoked by tooth-pulp stimulation in juvenile and adult rats. Results: Our results showed there were age differences in electroacupuncture-induced analgesic effects in rats, especially with naloxone antagonization. The ratio of naloxonereversibility against electroacupuncture analgesia was greater in adult rats than in juvenile rats. Conclusion: These results suggest that electroacupuncture analgesia is produced mainly by the non-opioid system in juvenile rats and by the opioid system in adult rats.
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