Evaluation of anti-inflammatory and antioxidant potential of the kernel root of Xylocarpus mekongensis (Lamk.) M. Roem

Jahan, Ismet Ara,Hossain, Md. Hemayet,Nimmi, Ishrat,Islam, Siblara,Kawsar, Md. Hassan,Islam, Md. Amirul 경희한의학연구센터 2012 Oriental Pharmacy and Experimental Medicine Vol.12 No.3

Anti-inflammatory and antioxidant activities of the crude ethanolic extract of the kernel root of Xylocarpus mekongenesis (Lamk.) M. Roem. (Meliaceae) was evaluated in different methods. The extract showed significant antiinflammatory activity in carrageenan-induced oedema test in rats showing 69.42 % reduction in the paw volume (P<0.01) comparable to that produced by the standard drug indomethacin (70.25 %) at 24 h when the extract was fed at the dose of 400 mg/kg body weight. The percentage inhibition of the oedema paw volume was statistically significant (p<0.05) when compared with the indomethacin treated animals at 0.5, 1, 2, 4 and 6 h. The extract exhibited $IC_{50}$ value 4.78 ${\mu}g/ml$ in DPPH free radical scavenging activity test that was found to be very significant and comparable to that of the standard antioxidants ascorbic acid and BHA (1.9372 and 4.81 ${\mu}g/ml$) respectively. In nitric oxide radical scavenging test, the $IC_{50}$ value was also found fairly significant 57.37 ${\mu}g/ml$ when compared to standard ascorbic acid (36.81 ${\mu}g/ml$). In reducing power test, the maximum absorbance of the same extract was observed as 1.923 at 100 ${\mu}g/ml$ and that of ascorbic acid and BHA were 2.8111 and 1.0314 respectively. The extract showed highest antioxidant capacity at 100 ${\mu}g/ml$ concentration expressed as equivalents of ascorbic acid (1.44). The total phenolic content of the extract was also found quite high ($342.15{\pm}0.92$ mg/g of gallic acid equivalent). Therefore, the results of this study suggest the probable anti-inflammatory and antioxidant activities of the ethanolic extract of X. mekongenesis kernel root and justify its use in traditional medicines.

Assessment of Menopausal Symptoms among Early and Late Menopausal Midlife Bangladeshi Women and Their Impact on the Quality of Life

( Kawsar Ahmed ),( Papia Jahan ),( Israt Nadia ),( Farzana Ahmed ),( Abdullah Al Emran ) 대한폐경학회 2016 대한폐경학회지 Vol.22 No.1

Objectives: Every physical abnormal criterion has an impact on the health. Late menopause causes different physiological problems which alike early menopause. The research interest is associated with both early and late menopausal women of Bangladesh as only few menopausal studies available in South East Asia especially in Bangladesh. The aims of this study are not only to assess the symptoms of menopausal abnormality but also to determine the impact of these symptoms on the quality of life (QOL) of the female society in Bangladesh. Methods: Data mining techniques are used to rank the 22 factors (conducted with questionnaire) commonly associated with menopause. Among the participants menstruation that stops before 45 years was considered as early menopausal status and after 50 years as late menopausal. The mean of age and mean length of time in years, since menopause for all participants were 61.55±10.7 and 14.13±11.17, respectively. Recorded data indicated 67% were early menopausal women and 33% were late menopausal women. Results: Results indicated that feeling tired or lacking in energy and dizziness (83%) and depression (82%) have worst impact on QOL among all factors, respectively. The next prevalent symptoms included hot flashes (64%), osteoporosis (72%), sweating at night (63%), concentration problem (75%), irritability (63%), feeling tense (77%), headache (66%). However, less frequent factors included breathing problems (33%), loss of feeling (31%), coherent heart disease (13%) and type2 diabetics (9%). Conclusion: Our study indicates that early menopausal women are facing more physiological problems than the late menopausal women on their QOL. (J Menopausal Med 2016;22:39-46)

Anti-inflammatory and antioxidant activities of the ethanolic extract of Ceriops decandra (Griff.) Ding Hou bark

Hemayet Hossain,Sk. Moniruzzaman,Ishrat Nimmi,Hassan Kawsar,Akbor Hossain,Amirul Islam,Ismet Ara Jahan 경희대학교 융합한의과학연구소 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.4

The crude ethanolic extract of the bark of Ceriops decandra (Griff.) Ding Hou (Family: Rhizophoraceae)was evaluated for its possible anti-inflammatory and antioxidant activities in different methods. At the dose of 400 mg/kg body weight, the extract showed a significant anti-inflammatory activity in the carrageenan-induced oedema test in rats showing 67.72% reduction in the paw volume (P<0.01) comparable to that produced by the standard drug indomethacin (69.29%) at 24 h. The percentage inhibition of the oedema paw volume by the 400 mg/kg body weight of the extract was also statistically significant (*P<0.05 and **p<0.01) compared favorably with the indomethacin treated animals at 1, 2, 4, 6 and 24 h. Three complementary test systems for determining the antioxidant activities of the ethanolic extract of C. decandra,namely DPPH free radical scavenging, reducing power, total phenolic contents determination were used for the analysis. In DPPH free radical scavenging test, IC_(50) value for the ethanolic crude extract was found fairly significant (12.90 μg/ml) while compared to the IC_(50) value of the reference standards ascorbic acid and butylated hydroxy anisole (2.9372 and 4.81 μg/ml) respectively. In reducing power test the absorbance for ethanolic extract was found to be 1.0900 at 100 μg/ml concentration while compared to 2.8111 and 1.0314 for standard ascorbic acid and BHA respectively at the same concentration. The amount of total phenolic content was also determined and calculated as quite high in the ethanolic extract (309.86 mg/g of gallic acid equivalent). Therefore, the obtained results tend to suggest the probable anti-inflammatory and antioxidant activities of the ethanolic extract of C. decandra bark and justify its use in folkloric remedies.

Anti-inflammatory and antioxidant activities of the ethanolic extract of $Ceriops$ $decandra$ (Griff.) Ding Hou bark

Hossain, Hemayet,Moniruzzaman, Sk.,Nimmi, Ishrat,Kawsar, Hassan,Hossain, Akbor,Islam, Amirul,Jahan, Ismet Ara 경희한의학연구센터 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.4

The crude ethanolic extract of the bark of $Ceriops$ $decandra$ (Griff.) Ding Hou (Family: Rhizophoraceae) was evaluated for its possible anti-inflammatory and antioxidant activities in different methods. At the dose of 400 mg/kg body weight, the extract showed a significant anti-inflammatory activity in the carrageenan-induced oedema test in rats showing 67.72% reduction in the paw volume ($P$ <0.01) comparable to that produced by the standard drug indomethacin (69.29%) at 24 h. The percentage inhibition of the oedema paw volume by the 400 mg/kg body weight of the extract was also statistically significant ($^*P$ <0.05 and $^{**}p$ <0.01) compared favorably with the indomethacin treated animals at 1, 2, 4, 6 and 24 h. Three complementary test systems for determining the antioxidant activities of the ethanolic extract of $C.$ $decandra$, namely DPPH free radical scavenging, reducing power, total phenolic contents determination were used for the analysis. In DPPH free radical scavenging test, $IC_{50}$ value for the ethanolic crude extract was found fairly significant (12.90 ${\mu}g$/ml) while compared to the $IC_{50}$ value of the reference standards ascorbic acid and butylated hydroxy anisole (2.9372 and 4.81 ${\mu}g$/ml) respectively. In reducing power test the absorbance for ethanolic extract was found to be 1.0900 at 100 ${\mu}g$/ml concentration while compared to 2.8111 and 1.0314 for standard ascorbic acid and BHA respectively at the same concentration. The amount of total phenolic content was also determined and calculated as quite high in the ethanolic extract (309.86 mg/g of gallic acid equivalent). Therefore, the obtained results tend to suggest the probable anti-inflammatory and antioxidant activities of the ethanolic extract of $C.$ $decandra$ bark and justify its use in folkloric remedies.

The Impact of Financial Leverage on Firm’s Profitability: An Empirical Evidence from Listed Textile Firms of Bangladesh

Md. Musfiqur RAHMAN,Farjana Nur SAIMA,Kawsar JAHAN 한국유통과학회 2020 Asian Journal of Business Environment (AJBE) Vol.10 No.2

Purpose: The purpose of this paper is to find out the impact of financial leverage on firm’s profitability in the listed textile sector of Bangladesh. Research design, data and methodology: A sample of 22 DSE listed textile firms has been used to conduct the study. In this study, firm profitability is measured by Return on Equity (ROE) and both short term debt and long term debt are used as the as proxies of financial leverage. Pooled Ordinary Least Squares (OLS), Fixed Effect (FE), and Generalized Method of Moments (GMM) models have been used to test the relationship between financial leverage and profitability of firms. Result: This study finds a significant negative relationship between leverage and firm’s profitability using the Pooled OLS method. The result is also consistent with the fixed effect and GMM method. This result implies that firm’s profitability is negatively affected by the firm’s capital structure. Conclusion: The study concludes that maximum textile firms use external debt as a source of finance as they don’t have sufficient internally generated funds. This study recommends that firm should give more emphasize on generating fund internally to meet up their financing needs.