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Kataoka, Kozo,Katai, Hitoshi,Mizusawa, Junki,Katayama, Hiroshi,Nakamura, Kenichi,Morita, Shinji,Yoshikawa, Takaki,Ito, Seiji,Kinoshita, Takahiro,Fukagawa, Takeo,Sasako, Mitsuru The Korean Gastric Cancer Association 2016 Journal of gastric cancer Vol.16 No.2
Several prospective studies on laparoscopy-assisted distal gastrectomy for early gastric cancer have been initiated, but no prospective study evaluating laparoscopy-assisted total gastrectomy or laparoscopy-assisted proximal gastrectomy has been completed to date. A non-randomized confirmatory trial was commenced in April 2015 to evaluate the safety of laparoscopy-assisted total gastrectomy and laparoscopy-assisted proximal gastrectomy for clinical stage I gastric cancer. A total of 245 patients will be accrued from 42 Japanese institutions over 3 years. The primary endpoint is the proportion of patients with anastomotic leakage. The secondary endpoints are overall survival, relapse-free survival, proportion of patients with completed laparoscopy-assisted total gastrectomy or laparoscopy-assisted proximal gastrectomy, proportion of patients with conversion to open surgery, adverse events, and short-term clinical outcomes. The UMIN Clinical Trials Registry number is UMIN000017155.
Can proximal Gastrectomy Be Justified for Advanced Adenocarcinoma of the Esophagogastric Junction?
Sato, Yuya,Katai, Hitoshi,Ito, Maiko,Yura, Masahiro,Otsuki, Sho,Yamagata, Yukinori,Morita, Shinji The Korean Gastric Cancer Association 2018 Journal of gastric cancer Vol.18 No.4
Purpose: To evaluate the status of number 3b lymph node (LN) station in patients with adenocarcinoma of the esophagogastric junction (AEG) and to investigate the optimal indications for radical proximal gastrectomy (PG) for AEG. Materials and Methods: Data of 51 patients with clinically advanced Siewert types II and III AEG who underwent total gastrectomy (TG) between April 2010 and July 2017 were reviewed. The proportion of metastatic LNs at each LN station was examined. Number 3 LN station was separately classified into number 3a and number 3b. The risk factors for number 3b LN metastasis and the clinicopathological features of number 3b-positive AEG patients were investigated. Results: The incidences of LN metastasis were the highest in number 1 (47.1%), followed by number 2 (23.5%), number 3a (39.2%), and number 7 (23.5%) LN stations. LN metastasis in number 3b LN station was detected in 4 patients (7.8%). A gastric invasion length of more than 40 mm was a significant risk factor for number 3b LN metastasis. All 4 patients with number 3b-positive AEG had advanced cancer with a gastric invasion length of more than 40 mm. The 5-year survival rate of patients with a gastric invasion length of more than 40 mm was 50.0%. Conclusions: Radical PG may be indicated for patients with AEG with gastric invasion length of less than 40 mm.
Can proximal Gastrectomy Be Justified for Advanced Adenocarcinoma of the Esophagogastric Junction?
Yuya Sato,Hitoshi Katai,Maiko Ito,Masahiro Yura,Sho Otsuki,Yukinori Yamagata,Shinji Morita 대한위암학회 2018 Journal of gastric cancer Vol.18 No.4
Purpose: To evaluate the status of number 3b lymph node (LN) station in patients with adenocarcinoma of the esophagogastric junction (AEG) and to investigate the optimal indications for radical proximal gastrectomy (PG) for AEG. Materials and Methods: Data of 51 patients with clinically advanced Siewert types II and III AEG who underwent total gastrectomy (TG) between April 2010 and July 2017 were reviewed. The proportion of metastatic LNs at each LN station was examined. Number 3 LN station was separately classified into number 3a and number 3b. The risk factors for number 3b LN metastasis and the clinicopathological features of number 3b-positive AEG patients were investigated. Results: The incidences of LN metastasis were the highest in number 1 (47.1%), followed by number 2 (23.5%), number 3a (39.2%), and number 7 (23.5%) LN stations. LN metastasis in number 3b LN station was detected in 4 patients (7.8%). A gastric invasion length of more than 40 mm was a significant risk factor for number 3b LN metastasis. All 4 patients with number 3b-positive AEG had advanced cancer with a gastric invasion length of more than 40 mm. The 5-year survival rate of patients with a gastric invasion length of more than 40 mm was 50.0%. Conclusions: Radical PG may be indicated for patients with AEG with gastric invasion length of less than 40 mm.
Kozo Kataoka,Hitoshi Katai,Junki Mizusawa,Hiroshi Katayama,Kenichi Nakamura,Shinji Morita,Takaki Yoshikawa,Seiji Ito,Takahiro Kinoshita,Takeo Fukagawa,Mitsuru Sasako,Stomach Cancer Study Group/Japan C 대한위암학회 2016 Journal of gastric cancer Vol.16 No.2
Several prospective studies on laparoscopy-assisted distal gastrectomy for early gastric cancer have been initiated, but no prospectivestudy evaluating laparoscopy-assisted total gastrectomy or laparoscopy-assisted proximal gastrectomy has been completed to date. Anon-randomized confirmatory trial was commenced in April 2015 to evaluate the safety of laparoscopy-assisted total gastrectomy andlaparoscopy-assisted proximal gastrectomy for clinical stage I gastric cancer. A total of 245 patients will be accrued from 42 Japaneseinstitutions over 3 years. The primary endpoint is the proportion of patients with anastomotic leakage. The secondary endpoints areoverall survival, relapse-free survival, proportion of patients with completed laparoscopy-assisted total gastrectomy or laparoscopy-assistedproximal gastrectomy, proportion of patients with conversion to open surgery, adverse events, and short-term clinical outcomes. TheUMIN Clinical Trials Registry number is UMIN000017155.
Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer
Sakamoto, Hiromi,Yoshimura, Kimio,Saeki, Norihisa,Katai, Hitoshi,Shimoda, Tadakazu,Matsuno, Yoshihiro,Saito, Daizo,Sugimura, Haruhiko,Tanioka, Fumihiko,Kato, Shunji,Matsukura, Norio,Matsuda, Noriko,Na Nature Pub. Co 2008 Nature genetics Vol.40 No.6
Gastric cancer is classified into intestinal and diffuse types, the latter including a highly malignant form, linitis plastica. A two-stage genome-wide association study (stage 1: 85,576 SNPs on 188 cases and 752 references; stage 2: 2,753 SNPs on 749 cases and 750 controls) in Japan identified a significant association between an intronic SNP (rs2976392) in PSCA (prostate stem cell antigen) and diffuse-type gastric cancer (allele-specific odds ratio (OR) = 1.62, 95% CI = 1.38–1.89, P = 1.11 × 10<SUP>−9</SUP>). The association was far less significant in intestinal-type gastric cancer. We found that PSCA is expressed in differentiating gastric epithelial cells, has a cell-proliferation inhibition activity in vitro and is frequently silenced in gastric cancer. Substitution of the C allele with the risk allele T at a SNP in the first exon (rs2294008, which has r<SUP>2</SUP> = 0.995, D′ = 0.999 with rs2976392) reduces transcriptional activity of an upstream fragment of the gene. The same risk allele was also significantly associated with diffuse-type gastric cancer in 457 cases and 390 controls in Korea (allele-specific OR = 1.90, 95% CI = 1.56–2.33, P = 8.01 × 10<SUP>−11</SUP>). The polymorphism of the PSCA gene, which is possibly involved in regulating gastric epithelial-cell proliferation, influences susceptibility to diffuse-type gastric cancer.
System Design based on Benefit of Inconvenience and Emotion
H. Kawakami,M. Nishimura,O. Katai,T. Shiose 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
Although the tools of today are developed to be convenient, they do not always satisfy people. Tools sometimes evoke negative feelings in people such that they get tired of using them. In consideration of this fact, to create guidelines for designing tools to make human life richer, this paper focuses on the relationship between the “benefit of inconvenience” and “emotional design.” After referring to their outlines and backgrounds, the discussion about their relationship leads to a proposal of characteristics that are required to be installed to artifacts to enrich human life, and refers to a strategy and applying it to system design theory.