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Karuppusamy Arunachalam,Shanmugam Saravanan,Thangaraj Parimelazhagan 한국식품과학회 2011 Food Science and Biotechnology Vol.20 No.1
The present study was carried out with ungerminated seed embryos of palmryah to evaluate nutritional quality with respect to minerals and fiber components, total phenols, and antioxidant properties. It is found to be good source of carbohydrate, fiber, fat, amino acids, and protein. Analysis of macro and micronutrient composition showed potent source of sodium, potassium, calcium, magnesium,zinc, and iron. In vitro antioxidant activity was evaluated by different assays, including 2,2-diphenylpicryl-1-picrylhydrazyl (DPPH) radical scavenging, 2,2'azinobis (3-ethylbenzothiozoline-6-sulfonic acid) disodium salt (ABTS^•+)assay, ferric reducing antioxidant power (FRAP) assay,phospomolybdenum reduction assay, metal chelating activity,and hydroxyl radical scavenging activity. The results indicate that this plant seed embryo possesses micro, macro nutrients and antioxidant properties and has nutraceuticals potential for the treatment of malnutrition.
Engineering pharmaceutical nanocarriers for photodynamic therapy on wound healing: Review
Shanmugapriya, Karuppusamy,Kang, Hyun Wook Elsevier S.A. 2019 Materials Science and Engineering C Vol. No.
<P><B>Abstract</B></P> <P>In the present scenario, promising efforts have been improved by the researchers towards the development of nanocarriers that can be challenge fundamental tasks in photodynamic therapy (PDT) for wound management. In the past few years, nanotechnology-based therapy has attracted good attention with the advancement of nanotechnology such as PDT, chemotherapy, photothermal therapy. PDT has emerged as a promising clinical treatment method for wound healing. In this respect, great effort has been made towards the development of nanocarriers for targeted PDT in wound management. Nowadays, attention is concentrated on the advancement of nanomaterials using innovative methods in wound care for treating wounds with the faster healing effect. In this review, we present and discuss how nanocarriers have arisen as an interesting delivery nanoplatform for effective and consistent PDT. They can be easily delivered photodynamically and can demonstrate healing mechanisms for achieving target wound tissue/cells; therefore, PDT can be used in wound treatment to target cells specifically through release on demand, target-specific delivery, and in vivo labelling imaging. In addition, we also highlighted that the future goal for researchers is the development of biocompatible and biodegradable nanomaterials for all the phases of wound healing.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Development of nanocarriers for PDT in wound healing process is of quite challenge. </LI> <LI> PDT is promising alternative approach for improved wound healing treatment method. </LI> <LI> Biocompatible biomaterials become a dynamic role in each wound healing stages. </LI> <LI> Pharmaceutical nanocarriers can significantly improve the wound healing efficacy. </LI> <LI> Nanocarrier systems may improve in vitro and in vivo applications of wound related. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Shanmugapriya, Karuppusamy,Kim, Hyejin,Saravana, Periaswamy Sivagnanam,Chun, Byung-Soo,Kang, Hyun Wook Elsevier 2018 Colloids and Surfaces B Vol.172 No.-
<P><B>Abstract</B></P> <P>Emulsion-based delivery systems have been fabricated and developed to increase the bioavailability of astaxanthin and alpha-tocopherol as active compounds for various biomedical applications. Astaxanthin-alpha tocopherol nanoemulsion (ATNE) is well known for its potential 6.–6.30 effect. The current study investigated ATNE by spontaneous (SENE) and ultrasonication emulsification (USNE) methods to optimally fabricate oil/water nanoemulsion characterized for biomedical applications. The two methods were compared by using a response surface method of 3-level Box-Behnken design (BBD) with significant factors. Transmission electron microscopy (TEM) confirmed spherical-shaped nanoemulsion from SENE and USNE methods and dynamic light scattering (DLS) proved the good stability of the fabricated nanoemulsion. Cytotoxicity studies on three different cancer cells confirmed that the nanoemulsion at higher concentrations was more toxic than one at lower concentrations by accompanying a significant decrease in the cellular viability after 24 and 48 h of exposure. The wound-healing potential using scratch assay evidenced faster healing effect of the nanoemulsion. Both minimal inhibitory concentration (MIC) and minimum bactericidal concentrations (MBC) methods confirmed significant antibacterial activity to disrupt the integrity of the bacterial cell membrane. The current results suggested that ATNE act as effectively targeted drug delivery vehicles in the future for cancer treatment applications due to its significant results of anticancer, wound healing, and antimicrobial effects.</P> <P><B>Highlights</B></P> <P> <UL> <LI> ATNE nanoemulsion showed small droplet size. </LI> <LI> It has maintained a kinetically high stability for three months. </LI> <LI> ATNEs at lower concentrations reduced cancer cell viability and induced apoptosis. </LI> <LI> It also increased fibroblast cell migration and disrupted bacterial cell membrane. </LI> <LI> The remarkable findings are good wound healing and antibacterial activities. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Shanmugapriya, Karuppusamy,Kim, Hyejin,Lee, Yong Wook,Kang, Hyun Wook Elsevier 2020 CERAMICS INTERNATIONAL Vol.46 No.6
<P><B>Abstract</B></P> <P>The present study evaluated the effect of fucoidan/alginate-polyethylene glycol-gellan gum (Fu/AL-PEG@GGH) hydrogel using low-level laser therapy (LLLT) on facilitating wound healing for wound care management. The hydrogel was fabricated and characterized to evaluate the wound healing potential. Cytotoxicity and apoptotic effects were evaluated with L929 and NIH3T3 cells. Uniform spherical sheets were observed with high thermal stability caused by porous matrixes with the increased cell viability and fast cell migration. Scar tissue was reduced by larger wound contraction with faster healing effects from the hydrogel + LLLT-treated group at day 14. The polysaccharides may promote wound healing due to the strong bonds by the physical cross-linking in hydrogel preparation. The results from hydrogel + LLLT-treated group confirmed an effective wound healing potential from the presence of high fibroblast and collagen deposition. Therefore, the combined practice of the hydrogel with LLLT may enhance a wound healing process for effective wound care applications.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Fu/AL-PEG@GG H was fabricated for wound healing applications. </LI> <LI> Fu/AL-PEG@GG hydrogel is non-toxic with faster cell migration. </LI> <LI> Polysaccharides evoked strong bonds by physical cross-linking in hydrogels. </LI> <LI> Hydrogel could promote collagen deposition and decrease the inflammation process. </LI> <LI> Fu/AL-PEG@GG hydrogel combined with LLLT resulted in the enhanced wound healing in an animal model. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Shanmugapriya, Karuppusamy,Kim, Hyejin,Saravana, Periaswamy Sivagnanam,Chun, Byung-Soo,Kang, Hyun Wook Elsevier 2018 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES Vol.118 No.2
<P><B>Abstract</B></P> <P>A nanocomposite film, chitosan (CS)-polyvinylpyrrolidone (PVP)-bentonite (BN) was fabricated to enhance wound healing processes as a new nanoplatform for wound dressing. Both physical properties and antibacterial activity of the proposed film were examined to validate its applicability and inhibitory effect for wound management. <I>In vitro</I> cytotoxicity was evaluated by using MTT assay on L929 and NIH3T3 cells to identify the toxicity level of the film. <I>In vivo</I> wound healing test assessed the wound healing performance in animal models. The results confirmed a strong interaction between surface functional groups among CS, PVP and BN with suitable surface morphology and high thermal stability. The CS-PVP-BN film improved various material features such as including mechanical property, tensile strength, pH and porosity, inhibitory activity on bacterial organisms, and collagen deposition. The animal study confirmed that the fabricated film yielded a rapid healing rate of 97%, less scarring, thick granulation at the 11th day, regeneration of epidermis at the 16th day, and abundant deposition of collagen and fibroblast, compared with control. The non-toxic nanocomposite film can be a promising antibacterial wound dressing with rapid wound healing effects in wound care management.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Greater surface interaction between new nanocomposite films with high thermal stability. </LI> <LI> Nanocomposite films have good antibacterial effect. </LI> <LI> Non-toxic films act as biocompatible antibacterial wound dressings. </LI> <LI> CS-PVP-BN2 films have the fastest healing rate (97%) with high collagen deposition and less scarring. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Schematic illustration of wound healing by using nanocomposite films as wound dressing.</P> <P>[DISPLAY OMISSION]</P>