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- 검색키워드
- 저자 : Kantappa S. Halake (검색결과 3 건)
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Blood-clotting mimetic behavior of biocompatible microgels
Mallinath S. Birajdar,Kantappa S. Halake,이종휘 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.63 No.-
Recent advances in hydrogel chemistry have led to the development of various soft materials capable of self-healing. Nevertheless, their self-healing capabilities are primitive compared to the responsive and adaptive strategies of blood clotting and wound healing in the human body. We developed a novel microgel system that mimics the process of blood clotting. Electrospun polylactic acid (PLA) fibers were entrapped inside the microgels of a hyaluronic acid conjugate with hesperidin side groups crosslinked by Fe ions; the resulting hydrogels showed fast self-healing and magnetic responsive properties. By applying an external magnetic field, which mimicked blood flow, the microgels successfully aggregated at target sites, like platelets. The aggregates were stable, as demonstrated by resistance to sonication for 30 min, and their moduli spanned tens to hundreds of kPa, demonstrating the mechanical integrity of the artificial clots. Like fibrin, the PLA fibers successfully strengthened the aggregates due to formation of uniform fiber-reinforced hydrogels; the artificial clots containing fibers had a 300% improved modulus and 50% increased hardness relative to the hydrogels without fibers. This unique intelligent system can be utilized in future self-healing systems, delivery systems, and devices with microfluidic channels.
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Blood-clotting mimetic behavior of biocompatible microgels
Birajdar, Mallinath S.,Halake, Kantappa S.,Lee, Jonghwi THE KOREAN SOCIETY OF INDUSTRIAL AND ENGINEERING 2018 JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY -S Vol.63 No.-
<P><B>Abstract</B></P> <P>Recent advances in hydrogel chemistry have led to the development of various soft materials capable of self-healing. Nevertheless, their self-healing capabilities are primitive compared to the responsive and adaptive strategies of blood clotting and wound healing in the human body. We developed a novel microgel system that mimics the process of blood clotting. Electrospun polylactic acid (PLA) fibers were entrapped inside the microgels of a hyaluronic acid conjugate with hesperidin side groups crosslinked by Fe ions; the resulting hydrogels showed fast self-healing and magnetic responsive properties. By applying an external magnetic field, which mimicked blood flow, the microgels successfully aggregated at target sites, like platelets. The aggregates were stable, as demonstrated by resistance to sonication for 30min, and their moduli spanned tens to hundreds of kPa, demonstrating the mechanical integrity of the artificial clots. Like fibrin, the PLA fibers successfully strengthened the aggregates due to formation of uniform fiber-reinforced hydrogels; the artificial clots containing fibers had a 300% improved modulus and 50% increased hardness relative to the hydrogels without fibers. This unique intelligent system can be utilized in future self-healing systems, delivery systems, and devices with microfluidic channels.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A blood-clotting mimetic system was developed based on fast self-healing and magnetic responsive behavior. </LI> <LI> Novel biodegradable microgels mimic platelets. </LI> <LI> Electrospun fibers entrapped in microgels mimic fibrins. </LI> <LI> They can form stable artificial clots of moduli spanned tens to hundreds of kPa. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>The novel microgels formed an artificial clot upon application of a magnetic field; this behavior can be utilized as a novel self-healing process or to prepare fiber-reinforced composites.</P> <P>[DISPLAY OMISSION]</P>
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