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Kang Yeon Jun,Song Woorim,Lee Su Jeong,Choi Seung Ah,Chae Sihyun,Yoon Bo Ruem,Kim Hee Young,Lee Jung Ho,Kim Chulwoo,Cho Joo-Youn,Kim Hyun Je,Lee Won-Woo 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-
Branched-chain amino acids (BCAAs), particularly leucine, are indispensable AAs for immune regulation through metabolic rewiring. However, the molecular mechanism underlying this phenomenon remains unclear. Our investigation revealed that T-cell receptor (TCR)-activated human CD4+ T cells increase the expression of BCAT1, a cytosolic enzyme responsible for BCAA catabolism, and SLC7A5, a major BCAA transporter. This upregulation facilitates increased leucine influx and catabolism, which are particularly crucial for Th17 responses. Activated CD4+ T cells induce an alternative pathway of cytosolic leucine catabolism, generating a pivotal metabolite, β-hydroxy β-methylbutyric acid (HMB), by acting on BCAT1 and 4-hydroxyphenylpyruvate dioxygenase (HPD)/HPD-like protein (HPDL). Inhibition of BCAT1-mediated cytosolic leucine metabolism, either with BCAT1 inhibitor 2 (Bi2) or through BCAT1, HPD, or HPDL silencing using shRNA, attenuates IL-17 production, whereas HMB supplementation abrogates this effect. Mechanistically, HMB contributes to the regulation of the mTORC1-HIF1α pathway, a major signaling pathway for IL-17 production, by increasing the mRNA expression of HIF1α. This finding was corroborated by the observation that treatment with L-β-homoleucine (LβhL), a leucine analog and competitive inhibitor of BCAT1, decreased IL-17 production by TCR-activated CD4+ T cells. In an in vivo experimental autoimmune encephalomyelitis (EAE) model, blockade of BCAT1-mediated leucine catabolism, either through a BCAT1 inhibitor or LβhL treatment, mitigated EAE severity by decreasing HIF1α expression and IL-17 production in spinal cord mononuclear cells. Our findings elucidate the role of BCAT1-mediated cytoplasmic leucine catabolism in modulating IL-17 production via HMB-mediated regulation of mTORC1-HIF1α, providing insights into its relevance to inflammatory conditions.
<i>Undibacterium piscinae</i> sp. nov., isolated from Korean shiner intestine
Lee, So-Yeon,Kang, Woorim,Kim, Pil Soo,Kim, Hyun Sik,Sung, Hojun,Shin, Na-Ri,Whon, Tae Woong,Yun, Ji-Hyun,Lee, Jae-Yun,Lee, June-Young,Jung, Mi-Ja,Jeong, Yun-Seok,Tak, Euon Jung,Han, Jeong Eun,Hyun, D Society for General Microbiology 2019 International journal of systematic and evolutiona Vol.69 No.10
<P> A novel Gram-stain-negative, non-spore-forming, obligate aerobic, motile, rod-shaped, and flagellated bacterium, designated S11R28<SUP>T</SUP>, was isolated from the intestinal tract of a Korean shiner, <I>Coreoleuciscus splendidus</I>. Based on 16S rRNA gene sequences, strain S11R28<SUP>T</SUP> was identified as member of the genus <I>Undibacterium</I> in class <I>Betaproteobacteria,</I> and was closely related to <I>Undibacterium parvum</I> DSM 23061<SUP>T</SUP> (98.49%). The isolate grew at 4-25℃, pH 6-9, with 0% (w/v) NaCl, and grew optimally at 20℃, pH 8, in the absence of NaCl. The main cellular fatty acids were C<SUB>16 : 0</SUB> and summed features 3 (C<SUB>16 : 1</SUB>ω7c and/or C<SUB>16 : 1</SUB>ω6c). The strain possessed diphosphatidylglycerol, phosphatidylglycerol, and phosphatidylethanolamine as predominant polar lipids, and ubiquinone Q-8 as a respiratory quinone. The polyamine profile composed of 2-hydroxyputrescine, spermidine, putrescine, and benzoic acid. A genomic DNA G+Ccontent was 51.4mol%. The average nucleotide identity between strains S11R28<SUP>T</SUP> and U. parvum DSM 23061<SUP>T</SUP> was 78.66%. Thus, <I>Undibacterium piscinae</I> can be considered a novel species within the genus <I>Undibacterium</I> with the type strain S11R28<SUP>T</SUP> (=KCTC 62668<SUP>T</SUP> =JCM 33224<SUP>T</SUP>). </P>
Lee, Jae-Yun,Kang, Woorim,Kim, Pil Soo,Lee, So-Yeon,Shin, Na-Ri,Sung, Hojun,Lee, June-Young,Yun, Ji-Hyun,Jeong, Yun-Seok,Han, Jeong Eun,Jung, Mi-Ja,Hyun, Dong-Wook,Kim, Hyun Sik,Tak, Euon Jung,Kang, M Society for General Microbiology 2019 International journal of systematic and evolutiona Vol.69 No.9
<P> A novel Gram-stain-negative, facultatively anaerobic, non-motile, non-violet-pigmented, rod-shaped bacterium, designated strain H11R3<SUP>T</SUP>, was isolated from the feces of Oriental stork, <I>Ciconia boyciana</I>, collected from Seoul Grand Park Zoo, Republic of Korea. Phylogenetic analysis of the 16S rRNA gene sequence revealed that H11R3<SUP>T</SUP> formed a monophyletic clade with <I>Iodobacter fluviatilis</I> DSM 3764<SUP>T</SUP>, <I>Iodobacter arcticus</I> DSM 100243<SUP>T</SUP>, and <I>Iodobacter limnosediminis</I> DSM 103822<SUP>T</SUP>, with sequence similarities of 98.8, 98.6 and 98.4%, respectively. H11R3<SUP>T</SUP> grew optimally at 15 ℃, pH 8, with 0.5% (w/v) NaCl. The predominant isoprenoid quinone was ubiquinone-8 (Q-8), and polar lipids included phosphatidylethanolamine, three unidentified lipids, four unidentified phospholipids, and two unidentified aminophospholipids. The major fatty acids were summed feature 3 and C<SUB>16 : 0</SUB>, and the DNA G+Ccontent of the genome is 48.0mol%. The average nucleotide identity (ANI) value between strains H11R3<SUP>T</SUP> and <I>I. fluviatilis</I> NCTC 11159<SUP>T</SUP> (=DSM 3764T) is 83.7%. On the basis of phenotypic, genotypic, phylogenetic and chemotaxonomic characteristics, strain H11R3<SUP>T</SUP> represents a novel species of the genus <I>Iodobacter</I> for which the name <I>Iodobacter ciconiae</I> sp. nov. is proposed. The type strain is H11R3<SUP>T</SUP> (=KCTC 62666<SUP>T</SUP>=JCM 33283<SUP>T</SUP>). </P>
Kim, Hyun Sik,Kim, Pil Soo,Hyun, Dong-Wook,Lee, June-Young,Kang, Woorim,Shin, Na-Ri,Whon, Tae Woong,Bae, Jin-Woo Microbiology Society 2016 International journal of systematic and evolutiona Vol.66 No.-
<P>A novel Gram-stain-negative, non-motile, non-spore-forming, non-flagellated, aerobic, beige-coloured and rod-shaped bacterium, designated strain KHSO2(T), was isolated from the intestinal tract of a Japanese flying squid, Todarodes pacificus, which was collected from the East Sea, Korea. Phylogenetic analysis of 16S rRNA gene sequences revealed that strain KHSO2(T) formed a monophyletic Glade with Pseudahrensia aquimaris HDW-32(T), with which it had the highest sequence similarity (98.67 %). Strain KHS02(T) grew optimally at pH 7 with 2 % (w/v) NaCI at 25 degrees C on marine broth 2216, but could not grow without Nat The predominant isoprenoid quinone was ubiquinone-10 (C1-10). The major fatty acids (>10 % of the total) were summed feature 8 C-18 : (1)omega 7C and/or C-18 : (1)omega 7C and 11-methyl C-18 : (1)omega 7C. The polar lipids of strain KHSO2(T) comprised phosphatidylcholine, phosphatidylglycerol, phosphatidylethanolamine, two unidentified aminolipids, an unidentified phospholipid and an unidentified lipid. The genomic DNA G+C content was 58.6 mol%. DNA DNA hybridization showed that the isolate shared 16.2+1.3 % (reciprocal, 15.7 +/- 2.8 %) genomic relatedness with the type strain of the closest species. In conclusion, this isolate is suggested to represent a novel species of the genus Pseudahrensia, for which the name Pseudahrensia todarodis is proposed. The type strain is KHSO2(T) (=KACC 18257(T)=JCM 30419(T)).</P>
Oceanisphaera avium sp. nov., isolated from the gut of the cinereous vulture, Aegypius monachus
Sung, Hojun,Kim, Hyun Sik,Lee, June-Young,Kang, Woorim,Kim, Pil Soo,Hyun, Dong-Wook,Tak, Euon Jung,Jung, Mi-Ja,Yun, Ji-Hyun,Kim, Min-Soo,Shin, Na-Ri,Whon, Tae Woong,Rho, Jeong Rae,Park, Sun Duk,Shim, Microbiology Society 2018 International journal of systematic and evolutiona Vol.68 No.6
Tumebacillus avium sp. nov., isolated from the gut of a cinereous vulture, Aegypius monachus
Sung, Hojun,Kim, Hyun Sik,Lee, June-Young,Kang, Woorim,Kim, Pil Soo,Hyun, Dong-Wook,Tak, Euon Jung,Jung, Mi-Ja,Yun, Ji-Hyun,Kim, Min-Soo,Shin, Na-Ri,Whon, Tae Woong,Rho, Jeong Rae,Park, Sun Duk,Shim, Microbiology Society 2018 International journal of systematic and evolutiona Vol.68 No.5