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Dan Xiao,Kaisen Huang,Qingyong Chen,Baotao Huang,Wei Liu,Yong Peng,Mao Chen,Dejia Huang,Tong Zou,Jiefu Yang 한국유전학회 2015 Genes & Genomics Vol.37 No.7
Apolipoprotein B plays a central role in lipoprotein metabolism. Many studies have evaluated the association between Apolipoprotein B gene polymorphisms (XbaI, EcoRI, SpIns/Del, MspI) and the risk for coronary artery disease and myocardial infarction. However, the results remain inconsistent, particularly among different populations. To more precisely determine the association between Apolipoprotein B gene polymorphisms and coronary artery disease/myocardial infarction risk, we performed a meta-analysis via a comprehensive search of electronic databases (up to February 1st, 2015), odds ratios (OR) and 95 % confidence intervals were calculated using a fixed or random effect model. A total of 47 studies, with 9411 coronary artery disease/myocardial infarction cases and 9082 controls, were included in this meta-analysis. The combined results revealed significant associations between an increased risk of coronary artery disease/myocardial infarction and EcoRI (AA vs GG: OR 1.511, 95 % confidence interval (CI) 1.098, 2.078) and SpIns/Del (DD vs II: OR 1.331, 95 % CI 1.064, 1.665) alleles in the general population. In a subgroup analysis stratified by ethnicity, the T allele of the XbaI variant was associated with a decreased risk in Caucasians, whereas it was associated with an increased risk among the East Asian population. No significant correlation was detected between the A allele of the MspI variant and the coronary artery disease/myocardial infarction risk in either the general population or any ethnic subgroup. The results of our study suggest that Apolipoprotein B gene polymorphisms may affect the coronary artery disease/myocardial infarction susceptibility and these effects may display notable discrepancies among different populations.
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Zhian Jin,Pujie Wang,Jie Chen,Li He,Lijia Xiao,Kaisen Yong,Shenglin Deng,Lin Zhou 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.5
Purpose: C-end rule (CendR) peptides are found to enhance the penetration of chemotherapeutic agents into tumor cells, whileGX1 is a peptide that homes to gastric cancer (GC) vasculature. This study aimed to synthesize a novel peptide GX1-RPAKPAR(GXC) and to explore the effect of GXC on sensitizing GC cells to chemotherapeutic agents. Materials and Methods: Intracellular Adriamycin concentration analysis was applied to conform whether GXC peptide increasesthe penetration of chemotherapeutic agents into GC cells in vitro. The effect of GXC peptide on sensitizing GC cells to chemotherapeuticswas validated by apoptosis assay and in vitro/vivo drug sensitivity assay. The specificity of GXC to GC tissue was validatedby ex vivo fluorescence imaging. Results: In vitro, administration of GXC significantly increased Adriamycin concentrations inside SGC-7901 cells, and enhancedthe efficacy of chemotherapeutic agents by decreasing the IC50 value. In vivo, FITC-GXC specifically accumulated in GC tissue. Moreover, systemic co-injection with GXC peptide and Adriamycin statistically improved the therapeutic efficacy in SGC-7901xenograft models, surprisingly, without obviously increasing side effects. Conclusion: These results demonstrated that co-administration of the novel peptide GXC with chemotherapeutic agents may bea potential way to enhance the efficacy of anticancer drugs in GC treatment.
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