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      • KCI등재

        Efficacy and Safety of Intravitreal Dexamethasone Implants for Treatment of Refractory Diabetic Macular Edema

        Erkan Unsal,Kadir Eltutar,Pınar Sultan,Sezin Ozdogan Erkul,Ozen Ayranci Osmanbasoglu 대한안과학회 2017 Korean Journal of Ophthalmology Vol.31 No.2

        Purpose: To evaluate the safety and efficacy of intravitreal dexamethasone (IVD) implants in eyes with diabeticmacular edema that did not respond to previous treatment. Methods: We included 46 eyes of 46 patients in this retrospective study. Each month, we recorded patient visualacuity with logarithm of the minimum angle of resolution using the Early Treatment Diabetic RetinopathyStudy chart, central macular thickness measurements with optical coherence tomography, intraocular pressure(IOP), and posttreatment complication occurrence. Results: The mean follow-up time was 8.95 ± 1.33 months (range, 6 to 12). Best-corrected visual acuity improvedsignificantly in the first 4 months after IVD, but no statistically significant change was observed over the following2 months. Although a statistically significant decrease in central macular thickness was observed in thefirst 3 months, the change was not statistically significant in the following 3 months. There was a statisticallysignificant increase in IOP in the first 2 months, but no statistically significant change was observed in the followingmonths. IOP was controlled with medication in all patients with elevated IOP. Of the 26 phakic patients,two had cataracts requiring surgery. Conclusions: Cases of refractory diabetic macular edema that did not respond to previous treatment, such asanti-vascular endothelial growth factor injections and laser photocoagulation, exhibited improvements in visualacuity and decreases in retinal thickness after IVD implantation. Both functional and anatomical effects wereobserved in the first 3 months after injection. Repeat injections and frequent examination might be required forcontinued improvement. Side effects, such as cataracts and elevation of IOP, may require medical or surgicaltreatment.

      • KCI등재

        A Study on Finding Optimum Parameters of a Diamagnetically Driven Untethered Microrobot

        Anil Demircali,Kadir Erkan,Huseyin Uvet 한국자기학회 2017 Journal of Magnetics Vol.22 No.4

        In this study, we present a theoretical and numeric analysis of an untethered microrobot manipulation technique that can be used in a liquid environment. A microrobot, which is levitated on a pyrolytic graphite surface, allows us to achieve high precision positioning (at nano level) and control with lower external magnetic force requirements due to stabilizing manner of its locomotion. Stabilizing microrobot is controlled via a single “lifter magnet” as a driving force that is placed on an automatic micro-stage in order to provide stable-motion about x, y and z axes. The presented microrobot is designed for single cell manipulation and transportation operations in liquid medium. It can be used in different experimental setups such as lab-on-a-chips, petri dishes. Here, a new approach to determine an optimal experimental setup of the diamagnetically levitated microrobot, which provides the most effective and possible microrobot control, is explained with FEM (Finite Element Method) analysis and required background information. For such untethered microrobot control experiments in a FEM program, determination of the size of materials used, selection criteria, required magnetic force effects, and optimum pyrolytic graphite sizes are discussed in detail. To do that, our proposed analysis method suggests how to construct such an FEM model parametrically in COMSOL<SUP>®</SUP>. Before starting the experimental work, the effects of the material and dimensions of each element forming the system on the microrobot are discussed in detail. Moreover, the manipulation technique which revealed the theoretical infrastructure is compared with the numerical calculations and the results are shown to be compatible with each other.

      • KCI등재

        Detailed Magnetic Force Analysis of A 4-Pole Hybrid Electromagnet by Magnetic Equivalent Circuit Method

        Hasan Fatih Ertu?rul,Kadir Erkan,Huseyin Uvet Korean Magnetics Society 2018 Journal of Magnetics Vol.23 No.4

        In this paper, detailed magnetic force analysis of a 4-pole hybrid electromagnet system providing an advantage of full-redundant levitation is studied. The novel fragmented magnetic equivalent circuit method (MEC) is developed to accurately capture inherited nonlinear characteristics of 4-pole hybrid electromagnet to investigate force characteristics and magnetic field distribution. To confirm this method, two possible scenarios, which are levitation under plain core and levitation under dual-linear motor are composed. As well as, they are examined by both proposed method and FEM analyses. Comparative analyses of both methods revealed that force, inclination torque, and mutual interference can be easily captured with adequate accuracy while at the same time yielding less computation and set up time. Furthermore, the fragmented formulations of permeance functions can be generalized for the analysis and the design of similar devices which specifically involve inclination motions.

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