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KANDELRUPESH,장세림,Upasana Ghimire,Sita Shrestha,Bishnu Kumar Shrestha,박찬희,김철생 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.120 No.-
Improving biomechanical and biochemical properties of tissue-engineered scaffolds akin to those ofnative stem-cell niches can effectively regenerate tissues. Bio-ceramic nanomaterials integrated porousscaffolds can be employed to promote bone cell proliferation and contribute to their translational value. Here, we successfully developed highly conductive fibrous scaffolds of polyurethane (PU) integratingFe3O4/SrO2 nanoparticles (NPs) in association with functionalized multiwall carbon nanotubes(fMWCNTs). The engineered scaffold of PU-Fe3O4/SrO2-fMWCNTs with 0.4 wt.% of NPs showed synergisticeffects on physicochemical and biological performances. The porous scaffold showed superior interfacialbiocompatibility, antibacterial properties, and load-bearing ability. Results of in vitro, including ALPactivity, collagen-I, and ARS staining of MC3T3-E1 cells confirmed that the scaffold provided a favorablemicroenvironment with a prominent effect on the growth, proliferation, and differentiation of MC3T3-E1cells. Furthermore, the up-regulated osteogenic protein expression of MC3T3-E1 cells was studied byqRT-PCR, and Western blotting and found the osteoblastic activity accelerated due to the enhanced mineralizationof PU-Fe3O4/SrO2-fMWCNTs (0.4 wt.%). Together, our findings suggest these scaffolds withimproved cell-interface compatibility exhibit osteoinductivity that could become a novelnanomaterial-based tissue construct as a therapeutic strategy for bone cell regeneration and bone defectrepair.
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