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RISS 인기검색어
- 검색키워드
- 저자 : Junying Zhou (검색결과 3 건)
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Clinical Biomarkers of Neurodegeneration in REM Sleep Behavior Disorder
Junying Zhou,Jihui Zhang,Siu Ping Lam,Xiangdong Tang,Yun Kwok Wing 대한수면연구학회 2015 Journal of sleep medicine Vol.12 No.2
Rapid eye movement (REM) sleep behavior disorder (RBD) is currently considered as a prodromal stage of α -synucleinopathies neurodegeneration. The update data suggested that over 80% patients with idiopathic RBD eventually developed neurodegenerative disease after a mean of 14 years interval from the onset of RBD. A series of potential biomarkers have been identified to predict the development of neurodegeneration in idiopathic RBD, including olfactory loss, color vision deficit, depression, mild cognitive impairment, excessive daytime sleepiness, dopamine dysfunction, and tonic EMG activity. Early recognition of the predictive markers of neurodegeneration in idiopathic RBD is essential for development of intervention or prevention strategies at the presymptomatic stage. Nonetheless, the current literature is lacking biomarkers that might reflect the α-synuclein neuropathology at the earliest stages. Future studies with large samples and systematic follow-up are needed to confirm more potential markers of neurodegeneration at its early stages.
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As a Modulator, Multitasking Roles of SIRT1 in Respiratory Diseases
Zhou Yunxin,Zhang Fan,Ding Junying 대한면역학회 2022 Immune Network Vol.22 No.3
As far the current severe coronavirus disease 2019 (COVID-19), respiratory disease is still the biggest threat to human health. In addition, infectious respiratory diseases are particularly prominent. In addition to killing and clearing the infection pathogen directly, regulating the immune responses against the pathogens is also an important therapeutic modality. Sirtuins belong to NAD+-dependent class III histone deacetylases. Among 7 types of sirtuins, silent information regulator type-1 (SIRT1) played a multitasking role in modulating a wide range of physiological processes, including oxidative stress, inflammation, cell apoptosis, autophagy, antibacterial and antiviral functions. It showed a critical effect in regulating immune responses by deacetylation modification, especially through high-mobility group box 1 (HMGB1), a core molecule regulating the immune system. SIRT1 was associated with many respiratory diseases, including COVID-19 infection, bacterial pneumonia, tuberculosis, and so on. Here, we reviewed the latest research progress regarding the effects of SIRT1 on immune system in respiratory diseases. First, the structure and catalytic characteristics of SIRT1 were introduced. Next, the roles of SIRT1, and the mechanisms underlying the immune regulatory effect through HMGB1, as well as the specific activators/inhibitors of SIRT1, were elaborated. Finally, the multitasking roles of SIRT1 in several respiratory diseases were discussed separately. Taken together, this review implied that SIRT1 could serve as a promising specific therapeutic target for the treatment of respiratory diseases.
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Bentian Yu,Haoqi Zhou,Junying Xia,Xiaolin Liu,Chao Xie,Kai Zhang 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.9
To research the performance of low-temperature sulfate corrosion resistance of concrete mixed with stone-powder in saline soil area of Qinghai-Tibet Plateau. In this work, the influence of the water-to-binder ratio and stone powder types on the low-temperature sulfate erosion behavior of cement-based materials was studied, and in order to predict its erosion life, a Wiener stochastic process model was established. The results show the following: 1) The samples of limestone powder cement-based materials (LCBM) with different water-to-binder ratios showed the same law in sulfate erosion; the greater the water-to-binder ratio is, the more serious the sample is eroded, and the difference is the rate of erosion reaction. The greater the water-to-binder ratio is, the earlier the characteristic peak of thaumasite appears. The electric pulse accelerated erosion lifetimes of the cement-based limestone powder with water binder ratios of 0.3, 0.4 and 0.5 were 185 days, 136 days and 110 days, respectively. 2) Quartz stone powder cement-based materials (QCBM) showed different erosion laws compared with LCBM. When soaked in sulfate, the macroscopic and microscopic changes of QCBM were basically in a mineral additives state, However, when the electric pulse accelerated the erosion, the QCBM was more severely attacked than the LCBM. The final erosion products of the cement-based limestone powder with water binder ratios of 0.4 are not only gypsum and ettringite but also thaumasite, while the quartz powder cement-based materials with water-binder ratios of 0.4 are only gypsum and ettringite.
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