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Eo, Jungwoo,Cha, Hee-Jae,Imai, Hiroo,Hirai, Hirohisa,Kim, Heui-Soo MARY ANN LIEBERT INC PUBL 2014 AIDS RESEARCH AND HUMAN RETROVIRUSES Vol. No.
<P>Endogenous retroviruses (ERVs), which are footprints of ancient germline infections, were inserted into the genome during the early stages of primate evolution. Human endogenous retroviruses (HERVs) occupy approximately 8% of the human genome. Although most ERV genes are defective, with large deletions, stop codons, and frameshifts in their open reading frames (ORFs), some full-length sequences containing long ORFs are expressed in several tissues and cancers. Several envelope glycoproteins that are encoded by env genes have retained some characteristics of their ancestral infectious viruses. These glycoproteins play essential physiological roles in the organs in which they are expressed. Previous studies have demonstrated the expression of ERV env at the mRNA level in cells and tissues rather than at the protein level, which is more difficult to detect. However, it is not known whether Env is functionally conserved in primates. To understand the possible role of Env in primates, we examined the expression of the env genes of four ERVs (ERV-R, -K, -W, and -FRD) at the protein as well as mRNA levels in various tissues of the rhesus monkey. The ERV env gene products were observed at moderate to high levels in each tissue that was examined and showed tissue-specific expression patterns. Our data suggest a biologically important role for retroviral proteins in healthy tissues of the rhesus monkey.</P>
Eo, JungWoo,Lee, Hee-Eun,Nam, Gyu-Hwi,Kwon, Yun-Jeong,Choi, Yuri,Choi, Bong-Hwan,Huh, Jae-Won,Kim, Minkyu,Lee, Sang-Eun,Seo, Bohyun,Kim, Heui-Soo Elsevier 2016 Gene Vol.580 No.2
<P><B>Abstract</B></P> <P>The monoamine oxidase A (<I>MAOA</I>) gene is an important candidate gene for human behavior that encodes an enzyme regulating the metabolism of key neurotransmitters. The regulatory mechanisms of the <I>MAOA</I> gene in dogs are yet to be elucidated. We measured <I>MAOA</I> gene transcription and analyzed the VNTR genotype and methylation status of the gene promoter region in different dog breeds to determine whether <I>MAOA</I> expression is correlated with the <I>MAOA</I> genotype or epigenetic modification in dogs. We found brain-specific expression of the <I>MAOA</I> gene and different transcription levels in different dog breeds including Beagle, Sapsaree, and German shepherd, and also a robust association of the DNA methylation of the gene promoter with mRNA levels. However, the 90bp tandem repeats that we observed near the transcription start site were not variable, indicating no correlation with canine MAOA activity. These results show that differential DNA methylation in the <I>MAOA</I> promoter region may affect gene expression by modulating promoter activity. Moreover, the distinctive patterns of <I>MAOA</I> expression and DNA methylation may be involved in breed-specific or individual behavioral characteristics, such as aggression, because behavioral phenotypes are related to different physiological and neuroendocrine responses.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The monoamine oxidase A (<I>MAOA</I>) gene is an important candidate gene. </LI> <LI> <I>MAOA</I> encodes an enzyme regulating the metabolism of key neurotransmitters. </LI> <LI> The patterns of <I>MAOA</I> expression and DNA methylation may be involved in breed-specific or individual behavior. </LI> <LI> The transcription levels of <I>MAOA</I> were also different in the brains of different dog breeds. </LI> <LI> The differential expression and DNA methylation of <I>MAOA</I> may contribute to differences in behavioral phenotypes of breeds. </LI> </UL> </P>
특수 목적견으로서의 품성 및 능력 관련 유전자들에 관한 생물정보학적 분석
권윤정(Yun-Jeong Kwon),어정우(Jungwoo Eo),최봉환(Bong-Hwan Choi),최유리(Yuri Choi),김정안(Jeong-An Gim),김다희(Dahee Kim),김태헌(Tae-Hun Kim),성환후(Hwan-Hoo Seong),김희수(Heui-Soo Kim) 한국생명과학회 2013 생명과학회지 Vol.23 No.11
특수 목적견(구조견, 군견, 안내견 및 탐지견)은 집중력, 소유욕, 대담성 등을 기반으로 한 훈련시험을 통해 선별된다. 최근 특수견으로서의 특수한 능력 및 품성에 대해 유전적인 정보가 중요한 인자로 다뤄지고 있다. 본 연구에서는 특수견으로서의 개의 특수한 능력 및 품성과 관련된 유전자들의 분자적인 특징을 고찰하고자 하였다. 이전 연구에서 보고된 24개의 유전자(AR, BDNF, DAT, DBH, DGCR2, DRD4, MAOA, MAOB, SLC6A4, TH, TPH2, IFT88, KCNA3, TBR2, TRKB, ACE, GNB1, MSTN, PLCL1, SLC25A22, WFIKKN2, APOE, GRIN2B, PIK3CG)를 선택하여 품성, 후각, 운동 및 학습능력 관련 유전자, 네 가지 카테고리로 분류하였다. 본 연구에서는 생물학적인 기법을 이용하여 이 유전자들의 염색체상의 위치, 유전자들 간의 네트워크를 통한 상호관계를 조사하였으며, 어떤 생물학적 기능과 관련이 있는지 Gene Ontology 분석과 데이터베이스를 기반으로 in silico 발현 양상을 살펴보았다. 또한 이전 연구를 통하여 품성 관련 유전자들의 다양한 유전적 다형성에 대한 보고를 조사하였다. 본 연구는 특수견으로서 주요하게 고려되는 개의 고유한 능력 및 품성 관련된 유전자에 대해 분자적 특징을 제시하고 있다. 이 후보 유전자들은 개의 특수한 표현형과의 관계를 밝힐 수 있는 연구의 기초자료로서 이용될 수 있을 뿐만 아니라 핵심적인 유전인자로 응용되어 신속하고 정확한 특수견 선발에 기여할 수 있을 것으로 전망된다. Working dogs, such as rescue dogs, military watch dogs, guide dogs, and search dogs, are selected by in-training examination of desired traits, including concentration, possessiveness, and boldness. In recent years, genetic information has been considered to be an important factor for the outstanding abilities of working dogs. To characterize the molecular features of the canine genes related to phenotypes for working dogs, we investigated the 24 previously reported genes (AR, BDNF, DAT, DBH, DGCR2, DRD4, MAOA, MAOB, SLC6A4, TH, TPH2, IFT88, KCNA3, TBR2, TRKB, ACE, GNB1, MSTN, PLCL1, SLC25A22, WFIKKN2, APOE, GRIN2B, and PIK3CG) that were categorized to personality, olfactory sense, and athletic/learning ability. We analyzed the chromosomal location, gene-gene interactions, Gene Ontology, and expression patterns of these genes using bioinformatic tools. In addition, variable numbers of tandem repeat (VNTR) or microsatellite (MS) polymorphism in the AR, MAOA, MAOB, TH, DAT, DBH, and DRD4 genes were reviewed. Taken together, we suggest that the genetic background of the canine genes associated with various working dog behaviors and skill performance attributes could be used for proper selection of superior working dogs.
Genetic structure and variability of the working dog inferred from microsatellite marker analysis
Kwon, Yun-Jeong,Choi, Bong-Hwan,Eo, Jungwoo,Kim, Choongrak,Jung, Yi-Deun,Lee, Ja-Rang,Choi, Yuri,Gim, Jeong-An,Lee, Dong-Hoon,Ha, Ji-Hong,Kim, Dae-Soo,Huh, Jae-Won,Kim, Tae-Hun,Seong, Hwan-Hoo,Kim, He Springer-Verlag 2014 Genes & Genomics Vol.36 No.2
Working dogs serve as military watch dogs, search dogs, rescue dogs, and guide dogs with un-come-at-able character. They are drafted by in-training examination including concentration, capacity for locomotion, boldness and earthly desires. In this study, genetic diversity and relationships among two groups of working dogs (pass and fail group in-training examination) were assessed based on 15 microsatellite markers in 25 individuals of working dogs (military watch dogs and Korean search dogs). For the 15 microsatellite markers, the values of allelic richness (A (R) ) ranged from 2.21 (pass group) to 1.60 (fail group) in military watch dogs, while A (R) ranged from 2.79 (pass group) to 2.72 (fail group) in Korean search dogs. Among 52 different alleles of military watch dogs, 22 alleles were detected in pass group only, while 8 alleles in fail group only. In case of Korean search dogs, 3 alleles were observed in pass group only, while 13 alleles in fail group only. These group-specific unique alleles reflect good biomarker for selecting working dogs (military watch dogs and Korean search dogs), indicating that those group specific microsatellite alleles could separate working dogs to be pass or fail group in out-training dog population. Taken together, this study demonstrates the feasibility of microsatellite analyses for the selection of superior working dogs objectively. Furthermore, this approach could be used for the proper selection of working dogs in combination with in-training examination.
Genetic diversity and population structure of three dog breeds through microsatellite loci analysis
Hoim Jeong(정호임),Bong-Hwan Choi,Jungwoo Eo,Yun-Jeong Kwon,Hee-Eun Lee,Yuri Choi,Jeong-An Gim,Tae-Hun Kim,Hwan-Hoo Seong,Dong-Hoon Lee,Ji-Hong Ha,Kook-Il Han,Heui-Soo Kim 한국실험동물학회 2014 한국실험동물학회 학술발표대회 논문집 Vol.2014 No.8
Structure and Expression Analyses of SVA Elements in Relation to Functional Genes
Kwon, Yun-Jeong,Choi, Yuri,Eo, Jungwoo,Noh, Yu-Na,Gim, Jeong-An,Jung, Yi-Deun,Lee, Ja-Rang,Kim, Heui-Soo Korea Genome Organization 2013 Genomics & informatics Vol.11 No.3
SINE-VNTR-Alu (SVA) elements are present in hominoid primates and are divided into 6 subfamilies (SVA-A to SVA-F) and active in the human population. Using a bioinformatic tool, 22 SVA element-associated genes are identified in the human genome. In an analysis of genomic structure, SVA elements are detected in the 5′ untranslated region (UTR) of HGSNAT (SVA-B), MRGPRX3 (SVA-D), HYAL1 (SVA-F), TCHH (SVA-F), and ATXN2L (SVA-F) genes, while some elements are observed in the 3′UTR of SPICE1 (SVA-B), TDRKH (SVA-C), GOSR1 (SVA-D), BBS5 (SVA-D), NEK5 (SVA-D), ABHD2 (SVA-F), C1QTNF7 (SVA-F), ORC6L (SVA-F), TMEM69 (SVA-F), and CCDC137 (SVA-F) genes. They could contribute to exon extension or supplying poly A signals. LEPR (SVA-C), ALOX5 (SVA-D), PDS5B (SVA-D), and ABCA10 (SVA-F) genes also showed alternative transcripts by SVA exonization events. Dominant expression of HYAL1_SVA appeared in lung tissues, while HYAL1_noSVA showed ubiquitous expression in various human tissues. Expression of both transcripts (TDRKH_SVA and TDRKH_noSVA) of the TDRKH gene appeared to be ubiquitous. Taken together, these data suggest that SVA elements cause transcript isoforms that contribute to modulation of gene regulation in various human tissues.