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Lee, Gyeong-Won,Park, Sung Woo,Go, Se-Il,Kim, Hoon-Gu,Kim, Min Kyoung,Min, Chang-Ki,Kwak, Jae-Yong,Bae, Sang-Byung,Yoon, Sung-Soo,Lee, Je-Jung,Kim, Ki Hwan,Nam, Seung-Hyun,Mun, Yeung-Chul,Kim, Hyo Jun S.Karger 2018 Acta haematologica Vol.140 No.3
<P><B><I>Background:</I></B> The neutrophil-to-lymphocyte ratio (NLR) is an independent prognostic marker in solid and hematological cancers. While the derived NLR (dNLR) was shown to be non-inferior to the NLR in large cohorts of patients with different cancer types, it has not been validated as a prognostic marker for multiple myeloma (MM) to date. <B><I>Methods:</I></B> Between May 22, 2011 and May 29, 2014, 176 patients with MM from 38 centers who were ineligible for autologous stem cell transplantation were analyzed. The dNLR was calculated using complete blood count differential data. The optimal dNLR cut-off value according to receiver operating characteristic analysis of overall survival (OS) was 1.51. All patients were treated with melphalan and prednisone combined with bortezomib. <B><I>Results:</I></B> The complete response rate was lower in the high dNLR group compared to the low dNLR group (7 vs. 26.1%, respectively; <I>p</I> = 0.0148); the corresponding 2-year OS rates were 72.2 and 84.7%, respectively (<I>p</I> = 0.0354). A high dNLR was an independent poor prognostic factor for OS (hazard ratio 2.217, 95% CI 1.015–4.842; <I>p</I> = 0.0458). <B><I>Conclusion:</I></B> The dNLR is a readily available and cheaply obtained parameter in clinical studies, and shows considerable potential as a new prognostic marker for transplantation-ineligible patients with MM.</P>
Jung, Eunhye,Lee, Joo-Youn,Kim, Ho Jeong,Ryu, Chung-Kyu,Lee, Kee-In,Kim, Meehyein,Lee, Chong-Kyo,Go, Yun Young Elsevier 2018 Bioorganic & medicinal chemistry letters Vol.28 No.14
<P><B>Abstract</B></P> <P>Picornaviruses are non-enveloped viruses that represent a large family of positive-sense single-stranded RNA viruses including a number of causative agents of many human and animal diseases such as coxsackievirus B3 (CVB3) and rhinoviruses (HRV). In this study, we performed a high-throughput screening of a compound library composed of ∼6000 small molecules in search of potential picornavirus 3C protease (3C<SUP>pro</SUP>) inhibitors. As results, we identified quinone analogues that effectively inhibited both CVB3 3C<SUP>pro</SUP> and HRV 3C<SUP>pro</SUP> with IC<SUB>50</SUB> values in low micromolar range. Together with predicted binding modes of these compounds to the active site of the viral protease, it is implied that structural features of these non-peptidic inhibitors may act as useful scaffold for further anti-picornavirus drug design and development.</P> <P><B>Highlights</B></P> <P> <UL> <LI> High-throughput screening assay of CVB3 3C<SUP>pro</SUP> inhibitors using FRET assay. </LI> <LI> Quinone analogues inhibited picornavirus 3C<SUP>pro</SUP> activity with nanomolar IC<SUB>50</SUB> values. </LI> <LI> Molecular docking predicted that 77035 and 169999 covalently bound in the active site of picornavirus 3C<SUP>pro</SUP>. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Lee, Yongseok,Yoo, Jung-Keun,Oh, Youngseok,Park, Hyunyoung,Go, Wonseok,Myung, Seung-Taek,Kim, Jongsoon The Royal Society of Chemistry 2018 Journal of Materials Chemistry A Vol.6 No.36
<P>We report a monoclinic Na2.4V2(PO4)3/poly(3,4-ethylenedioxythiophene) (M-NVP/PEDOT) composite as a novel cathode material for sodium-ion batteries. The active materials were homogenously encapsulated by thin layers of the electro-conductive polymer PEDOT, and X-ray diffraction analysis indicated that the final products were crystallized into a monoclinic structure. The composite exhibited much more outstanding power capability and cyclability than pristine M-NVP. The discharge capacity of the M-NVP/PEDOT electrode was maintained up to ∼109.8 mA h g<SUP>−1</SUP> at 10C (1C = ∼178 mA g<SUP>−1</SUP>), which was ∼9 times higher than that of pristine M-NVP under the same conditions. Moreover, whereas severe capacity degradation was observed for pristine M-NVP, the M-NVP/PEDOT composite delivered ∼81% capacity retention compared with the initial capacity over ∼500 cycles at 1C. In particular, the available capacity of M-NVP/PEDOT was ∼143.3 mA h g<SUP>−1</SUP>, corresponding to ∼2.4 mol Na<SUP>+</SUP> (de)intercalation, which is larger than the reversible capacity of rhombohedral Na3V2(PO4)3, at which only 2 mol Na<SUP>+</SUP> can be (de)intercalated. This unexpectedly high capacity of the M-NVP/PEDOT composite was clearly confirmed through combined studies using several experiments and first-principles calculation.</P>
Jung, Yeoun Joong,Park, Young Cheol,Lee, Ka Jeong,Kim, Min Seon,Go, Kyeong Ri,Park, Sang Gi,Kwon, Soon Jae,Yang, Ji Hye,Mok, Jong Soo Elsevier 2017 MARINE POLLUTION BULLETIN Vol.115 No.1
<P><B>Abstract</B></P> <P>We aimed to compare the spatial and seasonal distributions of fecal coliforms (FCs) and other physiochemical factors in the drainage basin of the Jaranman-Saryangdo area. Among the pollution sources, the mean daily loads and half-circle radii of FCs were the highest in June. However, the pollutants did not reach the boundary line of the designated area due to an existing buffer zone. The value of the FC geometric mean at station 1 was highest in August during periods of heavy rainfall; however, this value was lower than the regulation limit. The highest daily loads of chemical oxygen demand (COD) and chlorophyll-<I>a</I> (Chl-<I>a</I>) in seawater were in the surface layer in August; however, dissolved oxygen (DO) in the bottom water layer was at its lowest in August. This study demonstrated that season and rainfall have significant effects on the FC, COD, DO, and Chl-<I>a</I> concentrations in seawater.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The Jaranman-Saryangdo area can be easily contaminated by various drainage sources. </LI> <LI> The geometric mean for FCs was at its maximum in August periods of heavy rainfall in Korea. </LI> <LI> Season and rainfall have significant effects on the FC and physiochemical factors. </LI> </UL> </P>
( Go Eun Yang ),( Dong Sun Park ),( Sun Hee Lee ),( Dae Kwon Bae ),( Yun Hui Yang ),( Jang Been Kyung ),( Da Jeong Kim ),( Ehn Kyoung Choi ),( Jin Tae Hong ),( Heon Sang Jeong ),( Hee Jung Kim ),( Su 한국응용약물학회 2013 Biomolecules & Therapeutics(구 응용약물학회지) Vol.21 No.6
The neuroprotective effects of a butanol fraction of white rose petal extract (WRPE-BF) were investigated in a middle cerebral artery occlusion (MCAO) model. Seven week-old male rats were orally administered WRPE-BF for 2 weeks and subjected to MCAO for 2 h, followed by reperfusion. Twenty-four h later, MCAO-induced behavioral dysfunctions were markedly improved in a dose-dependent manner by pretreatment with WRPE-BF. Moreover, higher dose of WRPE-BF not only decreased infarction area but also effectively reduced astrogliosis. The expression of inducible nitric oxide synthase, cyclooxygenase-2, and glial fi brillary acidic protein in MCAO model were markedly inhibited by WRPE-BF treatment. Notably, WRPE-BF decreased nitric oxide and malondialdehyde levels in the striatum and subventricular zone of stroke-challenged brains. These data suggested that WRPE-BF may exert its neuroprotective effects via anti-oxidative and anti-infl ammatory activities against ischemia-reperfusion brain injury and could be a good candidate as a therapeutic target for ischemic stroke.
Go, Misun,Choi, Heekyoung,Kim, Ka Young,Moon, Cheol Joo,Choi, Yeonweon,Miyake, Hiroyuki,Lee, Shim Sung,Jung, Sung Ho,Choi, Myong Yong,Jung, Jong Hwa The Royal Society of Chemistry 2019 Organic chemistry frontiers Vol.6 No.8
<P>This study describes the temperature-controlled helicity inversion of supramolecular polymers based on <I>N</I>-triphenylamines (TPAs) bearing different numbers of d-alanine and/or glycine moieties. Despite chiral branching differences, the three investigated TPAs form helical supramolecular polymers <I>via</I> a typical nucleation-elongation model, characteristic of a cooperative assembly. The supramolecular polymer TPA-3, composed of symmetric tri-alanine segments, was more thermodynamically stable compared with TPA-1 and TPA-2, which had one or two alanine segments. More interestingly, at the microscopic level, temperature-dependent circular dichroism (CD) measurements revealed that the left-handed (<I>M</I>-type) helicity of supramolecular polymers TPA-1 and TPA-2 was inverted to the right-handed (<I>P</I>-type) helicity during heating. The (+/−) pattern of the vibrational circular dichroism (VCD) signal in the region of amide groups of self-assembled TPA-1 was also converted to the (−/+) pattern of the VCD signal. This indicates that the conformation of achiral gycine groups with the left-handed orientation was changed to the conformation of the glycine groups with the right-handed orientation. However, at the macroscopic level, the left- and the right-handed helical fibers were observed to coexist in self-assembled TPA-1 and TPA-2 at lower and higher temperatures. In contrast, no helicity conversion with the increase in temperature was observed for self-assembled TPA-3, which exhibited an ambiguous left-handed helical structure with a long helical pitch. Furthermore, the origin of the helical inversion at the microscopic level was supported <I>via</I> computational simulations. The helical inversion was possibly due to a molecular conformational change of flexible glycine moieties during the formation of supramolecular polymers. Based on AFM observations and DFT calculations, we conclude that even though either the positive or the negative signal of supramolecular polymers TPAs was obtained in CD spectra, the right- and the left-handed supramolecular polymer TPAs co-existed at the microscopic and macroscopic levels. Thus, the handedness of supramolecular polymers TPAs was determined by relative distribution of the right- and left-handed helical fibers.</P>