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Marcelo Bezerra Mendes,Jose Couras da Silva-Filho,Carla Kelly Barroso Sabino,Daniel Dias Rufino Arcanjo,Cleyton Marcos Melo Sousa,Isabella Cristhina Goncalves Costa,Mariana Helena Chaves,Rita de Ca´ss 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.10
Platonia insignis Mart. (Clusiaceae) is a medicinal plant from the Brazilian Amazon region. The present study evaluated the biological potential of the ethanol extract (Pi-EtOH) and ethyl acetate fraction (Pi-EtOAc) of the P. insignis fruit shells on the cardiovascular system of rats. Pi-EtOH or Pi-EtOAc (12.5, 25, and 50mg/kg) was administered intravenously in normotensive rats (260–300 g), and the mean arterial pressure and the heart rate were monitored. The Pi-EtOH induced hypotension ( - 11.56– 0.89, - 7.43– 0.85, and - 17.56– 1.97 mmHg) followed by bradycardia in two highest doses ( - 8.89– 3.62 and - 15.79– 1.83 beats/min) and Pi-EtOAc, at the same doses, induced hypotension ( - 11.2– 1.03, - 14.48– 1.13, - 29.89– 2.67 mmHg)more intensively, followedby tachycardia at thedose12.5and25mg/kg(15.64– 2.06, 19.31– 1.92 beats/min) and bradycardia at a dose of 50mg/kg (- 9.98– 7.33 beats/min). The hypotensive response from Pi-EtOAc was not attenuated when used in the pretreatment with L-NAME, verapamil, propranolol, and hexamethonium. However, when using yohimbine, the hypotensive effect was inhibited ( - 4.42– 1.28 (P< .05), - 3.29– 0.99 (P< .05), 2.06– 1.18 mmHg (P< .05); Student’s t-test). Hence, the Pi-EtOAc seems to act similarly to the a2-adrenergic agonist in this hypotensive effect.