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Combinatorial Approach Using Caenorhabditis elegans and Mammalian Systems for Aging Research
Lee, Gee-Yoon,Sohn, Jooyeon,Lee, Seung-Jae V. Korean Society for Molecular and Cellular Biology 2021 Molecules and cells Vol.44 No.7
Aging is associated with functional and structural declines in organisms over time. Organisms as diverse as the nematode Caenorhabditis elegans and mammals share signaling pathways that regulate aging and lifespan. In this review, we discuss recent combinatorial approach to aging research employing C. elegans and mammalian systems that have contributed to our understanding of evolutionarily conserved aging-regulating pathways. The topics covered here include insulin/IGF-1, mechanistic target of rapamycin (mTOR), and sirtuin signaling pathways; dietary restriction; autophagy; mitochondria; and the nervous system. A combinatorial approach employing high-throughput, rapid C. elegans systems, and human model mammalian systems is likely to continue providing mechanistic insights into aging biology and will help develop therapeutics against age-associated disorders.
@@@@@Double-stranded RNA Induction as a Potential Dynamic Biomarker for DNA-demethylating Agents
Minjeong KANG,Kharbash RAISA,Jamin BYUN,Jaemin JEON,Ali AHSAN,Doyeong KU,Jimin YOON,Yongsuk KU,Jooyeon SOHN,Seungjae LEE,Dongyeop SHIN,Youngil KOH,Sungsoo YOON,Junshik HONG,Yoosik KIM 한국생물공학회 2023 한국생물공학회 학술대회 Vol.2023 No.4