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유준상(Joonsang Yu),강성범(Sungbum Kang),최기영(Kiyoung Choi) 대한전자공학회 2018 대한전자공학회 학술대회 Vol.2018 No.11
This paper analyzes the knowledge distillation method from several perspectives. The knowledge distillation is commonly used to train a small network (student network) by preserving the accuracy of a large network (teacher network). In this paper, we investigate different types of knowledge distillation: from a smaller or the same teacher network instead of a larger teacher network. Moreover, we also cover the knowledge distillation for different network architecture. Even for a student network of the same size or larger, our experimental results show that the knowledge distillation achieves higher accuracy compared with back-propagation from the scratch.
Thrombus Volume as a Predictor of Nonrecanalization After Intravenous Thrombolysis in Acute Stroke
Yoo, Joonsang,Baek, Jang-Hyun,Park, Hyungjong,Song, Dongbeom,Kim, Kyoungsub,Hwang, In Gun,Kim, Young Dae,Kim, Seo Hyun,Lee, Hye Sun,Ahn, Seong Hwan,Cho, Han-Jin,Kim, Gyu Sik,Kim, Jinkwon,Lee, Kyung-Yu Ovid Technologies Wolters Kluwer -American Heart A 2018 Stroke Vol.49 No.9
Jinyoung Hong,Joonsang Yu,Hyunjung Gu,Juhee Lee,Woochang Lee,Sail Chun,Won-Ki Min 대한임상검사정도관리협회 2022 Journal of Laboratory Medicine And Quality Assuran Vol.44 No.3
Background: Next-generation sequencing (NGS)-based liquid biopsy testing using peripheral blood is a minimally invasive technique that can identify the characteristics of tumor-derived circulating tumor DNA (ctDNA) in cellfree DNA (cfDNA). External quality assessment (EQA) should be implemented to ensure the reliability of NGS-based liquid biopsy tests. This study aims to establish a method for producing EQA materials for NGS-based liquid biopsy tests. Methods: Eight cell lines harboring clinically important somatic mutations were selected for further analysis. Genomic DNA from the cell lines was extracted and fragmented using an ultrasonicator (Covaris Inc., USA). Two EQA materials were produced by spiking fragmented DNA into fresh frozen plasma and frozen at –70℃. The manufactured EQA materials were evaluated using a cfDNA gene panel (Dxome, Korea) using NextSeq Dx (Illumina, USA). Results: After sonication, the average sizes of the fragmented DNA were 203 and 201 bp, respectively. The results of the cell-free NGS panel showed a combination of different variants between the two EQA materials, and clinically important somatic mutations were detected as intended. Conclusions: In this study, a method for manufacturing materials for an NGS-based liquid biopsy test EQA scheme is presented. EQA materials with conditions similar to ctDNA clinical specimens can be produced at a relatively low cost using cell line-derived DNA and an ultrasonicator. The distribution of adequate EQA materials can improve the reliability of NGS-based liquid biopsy tests.