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Tyrosinase inhibitory flavonoid from <i>Juniperus communis</i> fruits
Jegal, Jonghwan,Park, Sang-a,Chung, KiWung,Chung, Hae Young,Lee, Jaewon,Jeong, Eun Ju,Kim, Ki Hyun,Yang, Min Hye Informa UK (TaylorFrancis) 2016 Bioscience, biotechnology, and biochemistry Vol.80 No.12
<P>The fruits of Juniperus communis have been traditionally used in the treatment of skin diseases. In our preliminary experiment, the MeOH extract of J. communis effectively suppressed mushroom tyrosinase activity. Three monoflavonoids and five biflavonoids were isolated from J. communis by bioassay-guided isolation and their inhibitory effect against tyrosinase was evaluated. According to the results of all isolates, hypolaetin 7-O--xylopyranoside isolated from J. communis exhibited most potent effect of decreasing mushroom tyrosinase activity with an IC50 value of 45.15M. Further study provided direct experimental evidence for hypolaetin 7-O--D-xylopyranoside-attenuated tyrosinase activity in -MSH-stimulated B16F10 murine melanoma cell. Hypolaetin 7-O--D-xylopyranoside from the EtOAc fraction of J. communis was also effective at suppressing -MSH-induced melanin synthesis. This is the first report of the enzyme tyrosinase inhibition by J. communis and its constituent. Therapeutic attempts with J. communis and its active component, hypolaetin 7-O--D-xylopyranoside, might be useful in treating melanin pigmentary disorders.</P>
Jeong, Eun Ju,Jegal, Jonghwan,Jung, Young-Suk,Chung, Ki Wung,Chung, Hae Young,Yang, Min Hye NATURAL PRODUCT COMMUNICATIONS 2017 Natural product communications Vol.12 No.7
<P>The bulbs of onion (Alliztm cepa L.) have long been used as food and dietary supplements in the treatment of various diseases. This study aimed to investigate anti-photoaging activities of fermented onions extract rich in flavonoids such as quercetin and isoquercetin. The fermented onions extract (FOE) effectively suppressed the melanin production by inhibition of tyrosinase expression in B16F10 melanoma cells at a concentration of 100 mu/mL. Besides, the FOE exhibited down-regulation of collagenase-1 expression and up-regulation of type I collagen level in UVB-irradiated HaCaT keratinocyte cells. Hyaluronic acid production was increased to 41.11% (10 mu g/mL), 107.78% (100 mu g/mL), and 146.67% (200 mu g/mL) compared with the UVB-irradiated control by treatment of FOE. Therapeutic attempts with FOE might be useful in preventing or treating melanin pigmentary diseases and UVB-induced wrinkle formation.</P>
Jo, Beom-Geun,Park, No-June,Jegal, Jonghwan,Choi, Sangho,Lee, Sang,Yi, Li,Kim, Su-Nam,Yang, Min Georg Thieme Verlag KG 2019 Planta medica Vol.85 No.7
<B>Abstract</B><P> Stellera chamaejasme, also known as “Langdu”, has been traditionally used for the management of skin-related diseases such as psoriasis and skin ulcers. The aim of this study was to determine whether S. chamaejasme and its major component, luteolin 7-O-glucoside, have a preventive effect on the development of atopic dermatitis in oxazolone-treated BALB/c mice and 2,4-dinitrochlorobenzene-treated hairless mice. The epicutaneous applications of oxazolone and 2,4-dinitrochlorobenzene evoke an experimental murine atopic dermatitis-like reaction in BALB/c mouse ears and SKH-1 hairless mice. Atopic skin symptoms, including erythema (redness), pruritus (itching), exudation (weeping), excoriation (peeling), and lichenification (skin thickening), responded to treatment with S. chamaejasme aerial parts EtOH extract for 2 or 3 weeks. Histopathological examination revealed S. chamaejasme aerial parts EtOH extract significantly reduced inflammatory cell infiltration when applied to atopic dermatitis mice. In addition, luteolin 7-O-glucoside, the major active compound of the S. chamaejasme aerial parts EtOH extract, decreased serum IgE and IL-4 levels and transepidermal water loss and increased skin hydration, therefore exhibiting strong anti-atopic dermatitis activity in 2,4-dinitrochlorobenzene-induced atopic dermatitis mice. In this study, we confirmed antipruritic and antidermatitic effects of S. chamaejasme extract and its main component luteolin 7-O-glucoside in atopic dermatitis murine models. The study shows S. chamaejasme aerial parts EtOH extract and luteolin 7-O-glucoside are most likely to be potential drug candidates for atopic dermatitis treatment.</P>
Jo, Beom-Geun,Park, No-June,Jegal, Jonghwan,Choi, Sangho,Lee, Sang Woo,Jin, Hang,Kim, Su-Nam,Yang, Min Hye Elsevier 2018 INTERNATIONAL IMMUNOPHARMACOLOGY Vol.59 No.-
<P><B>Abstract</B></P> <P> <I>Stellera chamaejasme</I> L. (family Thymelaeaceae), also known as ‘<I>Langdu</I>’, has been traditionally used to treat of skin-related diseases, such as, psoriasis and skin ulcers. The aim of this study was to identify the biologically active component of <I>S</I>. <I>chamaejasme</I> and evaluate its preventive effects on IL-4 and mast cell degranulation in RBL-2H3 cells and on the development of atopic dermatitis (AD) in 2,4-dinitrochlorobenzene (DNCB)-treated SKH-1 hairless mice. A novel flavonoid, genkwanin 5-<I>O</I>-xylosyl(1 → 2)glucoside (named stechamone), and three known compounds (umbelliferone, luteolin, and luteolin-7-<I>O</I>-glucoside) were isolated from the aerial parts of <I>S</I>. <I>chamaejasme</I> using chromatographic methods. Of these four compounds, stechamone most potently inhibited IL-4 production and mast cell degranulation in RBL-2H3 cells. Topical application of 0.5% stechamone improved atopic skin symptoms, including, erythema (redness), pruritus (itching), exudation (weeping), excoriation (peeling), and lichenification (skin thickening) in DNCB-treated AD mice by accelerating skin barrier recovery function and suppressing inflammatory cell infiltration. In addition, stechamone attenuated DNCB-induced increases in IL-4 (an inflammatory T<SUB>H</SUB>2 cytokine) expression and in serum IgE levels in our murine model of AD. DNCB induced AD-like skin lesions, but treatment with stechamone exhibited strong anti-atopic activity by regulating skin barrier function and reducing inflammatory responses. The results obtained suggest stechamone is a potential anti-atopic agent and treatment for skin inflammatory diseases.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A new flavonoid, stechamone, was isolated from <I>Stellera chamaejasme</I>. </LI> <LI> Stechamone exhibited potent IL-4 inhibitory activity in RBL-2H3 cells. </LI> <LI> 2,4-dinitrochlorobenzene was used to induce atopic dermatitis (AD) in hairless mice. </LI> <LI> Stechamone appeared to exert strong anti-AD effects on DNCB-stimulated mice. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Lee, Sullim,Park, No-June,Bong, Sim-Kyu,Jegal, Jonghwan,Park, Sang-a,Kim, Su-Nam,Yang, Min Hye Elsevier 2018 Journal of Ethnopharmacology Vol.214 No.-
<P><B>Abstract</B></P> <P><B>Ethnopharmacological relevance</B></P> <P>The fruits of <I>Juniperus rigida</I> have been used in Korean traditional medicine for the treatment of inflammatory diseases in humans such as rheumatoid arthritis.</P> <P><B>Aim of the study</B></P> <P>This study aimed to investigate the anti-atopic properties of <I>J. rigida</I> fruit in <I>in vivo</I> murine atopic dermatitis (AD) models.</P> <P><B>Methods and results</B></P> <P>BALB/c mouse ears ad SKH-1 hairless mice stimulated with oxazolone (4 weeks) and DNCB (3 weeks), respectively, were treated with the 1% <I>Juniperus rigida</I> fruit EtOH extract (JFE). The JFE improved AD symptoms in both oxazolone- and DNCB-induced AD mice by accelerating skin barrier recovery function and suppressing the overproduction of serum immunoglobulin E (IgE) and interleukin 4 (IL-4). The JFE was found to contain isoscutellarein-7-<I>O</I>-β-xylopyranoside, cupressuflavone, podocarpusflavone A, and hinokiflavone as major components based on phytochemical analysis. Eight flavonoids were isolated from JFE, and of those, cupressuflavone and isoscutellarein-7-<I>O</I>-β-xylopyranoside strongly down-regulated IL-4 expression and β-hexosaminidase release in RBL-2H3 cells.</P> <P><B>Conclusion</B></P> <P>Therapeutic attempts with <I>J. rigida</I> fruit and its active components might be useful in treating AD and related skin inflammatory diseases.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>