http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Synthesis and Evaluation of Homoazasugars as Glycosidase Inhibitors
Wong, Chi-Huey,Louis, Provencher,John A. Porco, Jr.,Jung, Sang-Hun,Wang, Yi-Fong,Chen, Lihren,Wang, Ruo,Darryl H. Steensma 충남대학교 약학대학 의약품개발연구소 1995 藥學論文集 Vol.11 No.-
In an effort to develop transition-state mimetics of the glycosidase-catalyzed reaction, five- and six-membered azasugars and their homo-analogs were prepared and tested as inhibitors of glycosidases. Inhibition studies indicate that the fucosyl cationlike, five-membered imine 1 and its reduced form 2 are potent inhibitors of α-fucosidase from bovine kideney with respective K_i values of 160 nM and 2μM. The five-membered homoaminoazasugar 3 is also a potent inhibitor of the enzyme (K_i=1.9×10^-6M), while the glucose and mannose-like six-membered homoaminoazasugars 4 and 5 are less potent than the corresponding 1-deoxyazasugars as inhibitors of α-glucosidase and α-mannosidase, respectively. The primary amino group was placed in an attempt to introduce additional electrostatic interactions in the active site. The inhibitory activities are, however, in the high μM range. Synthesis of homoazasugars structurally related to a disaccharide and a nucleoside is also described.
Intraoperative Cerebrospinal Fluid Leak in Extradural Spinal Tumor Surgery
Alexander E. Ropper,Kevin T. Huang,Allen L. Ho,Judith M. Wong,Stephen V. Nalbach,John H. Chi 대한척추신경외과학회 2018 Neurospine Vol.15 No.4
Objective: Patients with extradural spine tumors are at an increased risk for intraoperative cerebrospinal fluid (CSF) leaks and postoperative wound dehiscence due to radiotherapy and other comorbidities related to systemic cancer treatment. In this case series, we discuss our experience with the management of intraoperative durotomies and wound closure strategies for this complex surgical patient population. Methods: We reviewed our recent single-center experience with spine surgery for primarily extradural tumors, with attention to intraoperative durotomy occurrence and postoperative wound-related complications. Results: A total of 105 patients underwent tumor resection and spinal reconstruction with instrumented fusion for a multitude of pathologies. Twelve of the 105 patients (11.4%) reviewed had intraoperative durotomies. Of these, 3 underwent reoperation for a delayed complication, including 1 epidural hematoma, 1 retained drain, and 1 wound infection. Of the 93 uncomplicated index operations, there were a total of 9 reoperations: 2 for epidural hematoma, 3 for wound infection, 2 for wound dehiscence, and 2 for recurrent primary disease. One patient was readmitted for a delayed spinal fluid leak. The average length of stay for patients with and without intraoperative durotomy was 7.3 and 5.9 days, respectively, with a nonsignificant trend for an increased length of stay in the durotomy cases (p=0.098). Conclusion: Surgery for extradural tumor resections can be complicated by CSF leaks due to the proximity of the tumor to the dura. When encountered, a variety of strategies may be employed to minimize subsequent morbidity.
Biological Approaches to Treating Intervertebral Disk Degeneration: Devising Stem Cell Therapies
Han, Inbo,Ropper, Alexander E.,Konya, Deniz,Kabatas, Serdar,Toktas, Zafer,Aljuboori, Zaid,Zeng, Xiang,Chi, John H.,Zafonte, Ross,Teng, Yang D. Cognizant Communication Corp. 2015 CELL TRANSPLANTATION Vol.24 No.11