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JiSheng Hu,ShangJing Pi,MingRui Xiong,ZhongYing Liu,Xia Huang,Ran An,TongCun Zhang,BaiYin Yuan 한국분자세포생물학회 2020 Molecules and cells Vol.43 No.8
The migration, dedifferentiation, and proliferation of vascular smooth muscle cells (VSMCs) are responsible for intimal hyperplasia, but the mechanism of this process has not been elucidated. WD repeat domain 1 (WDR1) promotes actin-depolymerizing factor (ADF)/cofilin-mediated depolymerization of actin filaments (F-actin). The role of WDR1 in neointima formation and progression is still unknown. A model of intimal thickening was constructed by ligating the left common carotid artery in Wdr1 deletion mice, and H&E staining showed that Wdr1 deficiency significantly inhibits neointima formation. We also report that STAT3 promotes the proliferation and migration of VSMCs by directly promoting WDR1 transcription. Mechanistically, we clarified that WDR1 promotes the proliferation and migration of VSMCs and neointima formation is regulated by the activation of the JAK2/STAT3/WDR1 axis.
Yongsheng Fan,Yixi Cai,Xiaohua Li,Haiyun Yin,Jisheng Xia 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.46 No.-
HZSM-5 zeolite was employed in the upgrading of biomass pyrolysis vapors in this study. The cokingcharacteristics were investigated by means of TG, FT-IR, XRD, N2 adsorption–desorption, NH3-TPD, Py-IR,SEM and TEM methods. When the zeolite was used for three times about 120 min, its activity had beenlost and the amount of coke was 12.15% composed of 9.90% of I typefilamentous coke and 2.25% of II typegraphite-like coke. The skeleton structure of zeolite was basically intact, which had not been seriouslydestroyed by coke. The surface area, pore volume and acidity of zeolite were all deteriorated vary degreeswith the usage time. The zeolite granules became larger after deactivated, and thefilamentous coke canbe observed both on the surface and in the pore. The compositions of the coke precursors were analyzedby FT-IR and GC/MS. The precursors of coke deposited in the pore were mainly aromatic hydrocarbons,while the species of the precursors deposited on the outer surface was more including many long-chainsaturated hydrocarbons. The deactivation of HZSM-5 zeolite began from inner, large molecularsubstances blocked the pores which resulted in the zeolite deactivation eventually