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Min, Jiho,Ahn, Ji-Young,Sekhon, Simranjeet Singh,Jin, Yoon Mi,Um, Hyun-Ju,Jo, Inho,Kim, Yang-Hoon 대한독성유전단백체학회 2014 Molecular & cellular toxicology Vol.10 No.2
Cigarette smoke is a contributory factor for the cardiovascular disease, lung diseases and cancers as the dominant illnesses. The proteomic analysis of bovine aortic endothelial cells (BAECs) exposed to cigarette smoke has been performed in the broad (Non-linear pH 3-11) and narrow (Linear pH 4-7) range by using two-dimensional gel electrophoresis (2-DE). Out of an average 950 spots observed in 2-DE gels under pH 3-11, the expression level of 25 proteins significantly increased with an increase of cigarette smoke extract (CSE) level, whereas 21 proteins were strongly down-regulated. In narrow (4-7) pH range analysis, 80 proteins showed a significant change in expression level as compared with control. Some of the proteins were found to show similar spot intensity patterns in both the linear (4-7) and nonlinear (3-11) pH ranges. Most of the proteins identified in both pH conditions were found to be involved in apoptosis, inflammation, transcription modulator, signal transduction pathway, ROS production, cell proliferation and extracellular structure formation. In addition, extracellular structural proteins also responded to apoptotic signaling as an indicator. The findings of the present study can be used as an early biomarker to indicate the risks of cigarette smoke related diseases and also in the design of new therapeutic and diagnostic approaches to control these diseases.
쑥갓 중 metalaxyl-M과 dinotefuran 입제의 잔류 특성 및 위해성 평가
송민호 ( Min-ho Song ),유지우 ( Ji-woo Yu ),김진찬 ( Jinchan Kim ),이광헌 ( Kwanghun Lee ),고락도 ( Rakdo Ko ),금영수 ( Young-soo Keum ),이지호 ( Jiho Lee ) 한국환경농학회 2022 한국환경농학회 학술대회집 Vol.2022 No.-
Glebionis coronaria (called crown daisy) is commonly consumed in the Republic of Korea due to its unique smell. Since the Positive List System (PLS) was enforced in the Republic of Korea, Maximum Residue Limits (MRLs) of many crops have been established. However, the pesticides available for the crown daisy are still limited. In this study, the residual characteristics of metalaxyl-M and dinotefuran in crown daisy were investigated to expand the registration of pesticides. Additionally, risk assessment was performed by using the residual concentration of pesticides and dietary intake. Two pesticides were treated in soil on two levels, and samples were collected 51 days after seeding. The analytes were extracted using acetonitrile and the QuEChERS extraction packet (MgSO4 4 g, NaCl 1 g). The mixture was centrifuged at 4,000 rpm for 5 min, and the supernatant was diluted 1:1 with acetonitrile. The results for the concentration of pesticides were obtained with a high-performance liquid chromatography-triple quadrupole mass spectrometer. The quantitative methods for analytes were validated in linearity, accuracy, and precision. Daily dietary intake was obtained from Korea national nutrition statistics 2019. The residual concentration of metalaxyl-M in crown daisy were 0.09∼0.10 mg/kg (6 kg/10 a) and 0.17∼0.19 mg/kg (12 kg/10 a), respectively. The residual concentrations of dinotefuran in the crop were 0.53∼0.75 mg/kg (3 kg/10 a) and 1.17∼1.26 mg/kg (6 kg/10 a), each. The amounts of pesticides were less than the MRL specified by the Korean Ministry of Food and Drug Safety. The Hazard Index (HI) of metalaxyl-M and dinotefuran for consumers was 0.0075% and 0.2250%, respectively. For females in the age between 50∼64, the major consumer group, the HIs of the pesticides were <3%. Considering the consumption of crown daisy, they are not concidered to be of toxicological concern.