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- 저자 : Jiaying Long (검색결과 2 건)
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Atractylenolides (I, II, and III): a review of their pharmacology and pharmacokinetics
Mao Deng,Huijuan Chen,Jiaying Long,Jiawen Song,Long Xie,Xiaofang Li 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.7
Atractylodes macrocephala Koidz is a widelyused as a traditional Chinese medicine. Atractylenolides(-I, -II, and -III) are a class of lactone compounds derivedfrom Atractylodes macrocephala Koidz . Research intoatractylenolides over the past two decades has shown thatatractylenolides have anti-cancer, anti-infl ammatory, antiplatelet,anti-osteoporosis, and antibacterial activity; protectthe nervous system; and regulate blood glucose and lipids. Because of structural diff erences, both atractylenolide-I andatractylenolide-II have remarkable anti-cancer activities,and atractylenolide-I and atractylenolide-III have remarkableanti-infl ammatory and neuroprotective activities. Wetherefore recommend further clinical research on the anticancer,anti-infl ammatory and neuroprotective eff ects ofatractylenolides, determine their therapeutic eff ects, aloneor in combination. To investigate their ability to regulateblood glucose and lipid, as well as their anti-platelet, antiosteoporosis,and antibacterial activities, both in vitro andin vivo studies are necessary. Atractylenolides are rapidlyabsorbed but slowly metabolized; thus, solubilization studiesmay not be necessary. However, due to the inhibitory eff ectsof atractylenolides on metabolic enzymes, it is necessaryto pay attention to the possible side eff ects of combiningatractylenolides with other drugs, in clinical application. Inshort, atractylenolides have considerable medicinal valueand warrant further study.
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Zhang Zu-Bing,Yin Ning-Na,Long Ji-Ming,Zhang Yong-Ke,Liu Nai-Yong,Zhu Jiaying 한국응용곤충학회 2021 Journal of Asia-Pacific Entomology Vol.24 No.1
Noorda blitealis (Lepidoptera: Pyraloidea: Crambidae) is a major defoliating pest of Moringa trees. Focusing on its mating and reproduction, here we sequenced and analyzed the transcriptome of its pheromone glands (PGs) with a combination of Illumina sequencing, bioinformatics and phylogenetics approaches, coupled with a genomebased analysis. Transcriptome sequencing led to the yields of approximately 162 million clean reads, which were assembled into 60,578 unigenes and 121,692 transcripts, respectively. From the transcriptome, totally 117 genes encoding eight pheromone biosynthesis enzymes and one pheromone degradation enzyme were identified, 90 of which had complete open reading frames. A comparative analysis between PGs and bodies (removing PGs) revealed a large number of differentially expressed genes, including 79 pheromone biosynthesis and degradation related genes. Of the identified genes, NbliDES12 belonging to the △11 desaturase group was likely to a strong candidate for the desaturation of sex pheromones in N. blitealis, as implied by phylogenetic analyses and expression profiles. Finally and most notably, through genome and transcriptome analyses we discovered, for the first time, a novel aldehyde oxidase 6 (AOX6) group of the superfamily Pyraloidea that have been slightly expanded by gene duplications. Moreover, each orthologous AOX group shared highly conserved gene structure. Together, this current study has characterized the genes associated with sex pheromone biosynthesis and degradation from the PG transcriptome of N. blitealis, and more importantly, identifies a novel AOX group of the Pyraloidea.
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