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RISS 인기검색어
- 검색키워드
- 저자 : Jiaye Xu (검색결과 3 건)
- 무료
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Metabolism Characteristics of Mycoplasma pneumoniae Infection in Asthmatic Children
Luo Jiaying,Chen Huian,Zhang Qiyong,Huang Xinyun,Qin Xu,Li Jing,Chen Siyi,Xiao Yongxin,Sun Lihong,Sun Baoqing 대한천식알레르기학회 2022 Allergy, Asthma & Immunology Research Vol.14 No.6
Purpose: Studies have shown that Mycoplasma pneumoniae (Mp) infection can aggravate symptoms in asthmatics. However, the mechanism by which Mp infection exacerbates asthma remains unclear. Metabolomics can help identify the mechanism of Mp aggravating asthma in children, thereby providing more a potential target for improving clinical treatment programs. In this article, we analyzed the metabolic level of patients to explain how Mp aggravates asthma in children. Methods: We divided the subjects into the asthma, Mp infection, asthma combined with Mp infection and healthy groups. Patients’ peripheral blood was collected for metabolic and interaction analysis. Cytokine levels were measured via serum and exhaled breath condensate (EBC). Results: A total of 150 participating subjects were divided into four groups after exclusion. We found out that there were different metabolic pathways between the healthy and disease groups. The major pathways of both asthma and asthma combined with Mp infection were valine, leucine and isoleucine biosynthesis; malate-aspartate shuttle was the main differential pathway for Mp infection. Moreover, even though three disease groups involved 81 metabolites at the same time, compared with asthma combined with Mp infection, 2 single disease groups still involved different amino acid pathways (phenylalanine, tyrosine and tryptophan biosynthesis; valine, leucine and isoleucine biosynthesis). Interaction analysis showed that Mp infection in asthmatic patients not only activated cytokines, but also activated Toll-like receptors (TLRs) 2 and 6. Finally, the levels of interleukin (IL)-4, IL-8, IL-13 and tumor necrosis factor-α in EBC with asthma combined with Mp infection were significantly higher than the 2 single disease groups. Conclusions: Mp infection in asthmatic children can cause changes in the levels of various amino acids in the body, which were enriched in the pathways such as valine, leucine and isoleucine biosynthesis. Palmitic acid can activate TLR2, and iloprost reduces IL-10 levels, ultimately leading to the increased airway inflammation.
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Lingling Li,Zhenghai Liu,Jiaye Xu,Xuedong Ma 한국전기전자재료학회 2020 Transactions on Electrical and Electronic Material Vol.21 No.3
In order to enhance the segregation eff ect of material particles in a hemispherical shell swing-oscillating trough under combination swing-oscillating, by means of three dimensional discrete element method, and by use of the two-dimensional dry granules of plastic ball and steel ball, the discrete element simulation study of particle segregation process is carried out in turn in three cases, which is composed of a single swing-oscillating in smooth trough, a combination swing-oscillating in smooth trough, and a combination swing-oscillating in adding bulge trough. The particle segregation eff ect was evaluated by particle volume concentration and combined with segregation cloud picture simulated. The result indicates that segregation effect of combination swing-oscillating is better than that in single swing-oscillating; layering eff ect of the trough added bulge is better than that in the smooth trough. And compared to single swing-oscillating in smooth trough, the degree of segregation of particles in added bulge trough can be increased by 10–15% when being combination swing-oscillating.
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Liang Cai,Cai Jiaying,Xu Guiling,Xu Pan,Chen Xiaoping,Zhao Changsui 한국화학공학회 2013 Korean Journal of Chemical Engineering Vol.30 No.2
Conveying characteristics and flow stability are very important for design and control of a conveying system at high pressure. The influences of operating parameters and material properties on conveying characteristics were investigated in an experimental test facility with a conveying pressure up to 4MPa. Wavelet transform and Shannon entropy analysis were applied to analyzing pressure drops through horizontal pipe in order to obtain the stability criterion. Results indicated that the mass flow rate of biomass decreased, while the mass flow rate of pulverized coal increased at first and then decreased with the increase in fluidization velocity. Solid loading ratios for four kinds of powders decreased with the increase in fluidization velocity. Conveying phase diagrams and pressure drops through different test sections of pulverized coal and biomass at high pressure were obtained and analyzed. The influences of coal category,fracture characteristics and particle size on conveying characteristics were determined.
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