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Jiao Yuanyuan,Wu Yepeng,Lu Qiang Steven 기술경영경제학회 2020 ASIAN JOURNAL OF TECHNOLOGY INNOVATION Vol.28 No.2
Drawing upon the knowledge-based view, this study divides firm knowledge-processing capability (KPC) into market and technical knowledge-processing capabilities, and examines the moderating effect of social media use and two knowledge-processing capabilities on customer participation (CP) in new product development (NPD). The results show that social media use enhances the effect of customer participation on NPD performance (product innovativeness, market performance, and financial performance); firms’ two key capabilities (market knowledge-processing capability and technical knowledge-processing capability) further strengthen the moderating effect of social media use. Furthermore, the effect of customer participation on product innovativeness follows an inverted U-shape. This study not only confirms the crucial role of social media use and firm capabilities in customer participation in NPD but also provides firms with theoretical direction for how to use social media.
Study on Carbon Sequestration Capacity of Typical Crops in Northern China
Tianxin Li,Fang Zhang,Yuanyuan Jiao,Minjie Zhang,Yanhong Chang,Nametso Matomela 한국식물학회 2019 Journal of Plant Biology Vol.62 No.3
The carbon sequestration potential of differentcrops in their mature period in Northern China was analyzedin order to promote the selection of green species. Carbondioxide infrared gas detection, three-dimensional fluorescence,fixed carbon enzyme activity analysis and other methodswere used to test the carbon sequestration capacity of ninerepresentative mature crops in the Beijing area. Results showthat the carbon sequestration capacity of the nine crops was:corn > sorghum > wheat > tomato > cucumber > cabbage >celery > eggplant > pepper. Among them, the carbonsequestration capacity of corn and sorghum which are C4crops was stronger than that of other crops. Meanwhile, thethree-dimensional fluorescence spectra of corn were closer tosorghum, and there were significant differences in thecharacteristics of the three-dimensional fluorescence spectraof C3 crops. Based on the analysis of the activity of the fixedcarbon enzyme—Phosphoenolpyruvate Carboxylase (PEP)carboxylase and Ribulose-1, 5-Bisphosphate (RuBP)Carboxylase of these plants show that the carbon sequestrationcapacity of C4 crops was much larger than C3 crops becauseof its higher PEP carboxylase activity. The carbon sequestrationcapacity of C3 crops was positively correlated with theactivity of RuBP carboxylase in addition to cabbage. Therefore,the carbon sequestration capacity of crops can be measuredby using the portable carbon dioxide infrared analyzer.
Bulitta, Jü,rgen B.,Paik, Soo Heui,Chi, Yong Ha,Kim, Tae Hwan,Shin, Soyoung,Landersdorfer, Cornelia B.,Jiao, Yuanyuan,Yadav, Rajbharan,Shin, Beom Soo Elsevier 2017 European journal of pharmaceutical sciences Vol.107 No.-
<P><B>Abstract</B></P> <P>Fimasartan is a novel angiotensin II receptor blocker. Our aims were to characterize the time-course of the antihypertensive activity of fimasartan <I>via</I> a new population pharmacokinetic/pharmacodynamic model and to define its optimal dose range. We simultaneously modelled all fimasartan plasma concentrations and 24-h ambulatory blood pressure monitoring (ABPM) data from 39 patients with essential hypertension and 56 healthy volunteers. Patients received placebo, 20, 60, or 180mg fimasartan every 24h for 28days and healthy volunteers received placebo or 20 to 480mg as a single oral dose or as seven doses every 24h. External validation was performed using data on 560 patients from four phase II or III studies. One turnover model each was used to describe diastolic and systolic blood pressure. The input rates into these compartments followed a circadian rhythm and were inhibited by fimasartan. The average predicted (observed) diastolic blood pressure over 24-h in patients decreased by 10.1±7.5 (12.6±9.2; mean±SD)mmHg for 20mg, 14.2±7.0 (15.1±9.3) mmHg for 60mg, and 15.9±6.8 (11.5±9.9)mmHg for 180mg daily relative to placebo. The model explained the saturation of antihypertensive activity by counter-regulation at high fimasartan concentrations. Drug effect was maximal at approximately 23ng/mL fimasartan for diastolic and 12ng/mL for systolic blood pressure. The proposed mechanism-based population model characterized the circadian rhythm of ABPM data and the antihypertensive effect of fimasartan. After internal and external model validation, 30 to 60mg oral fimasartan given once daily was predicted as optimal dose range.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>