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Lei Cai,Jianjun Li,Lujun Yu,Yuanzheng Wei,Zongyu Miao,Meili Chen,Ren Huang 한국유전학회 2019 Genes & Genomics Vol.41 No.1
Benzo[a]pyrene (BaP) is one of the most studied targets among polycyclic aromatic hydrocarbons (PAHs). Because of the complexity of the toxicity mechanism in BaP, little is known about the molecular mechanism at the level of transcription of BaP in marine fishes. The primary objective of this study was to investigate the molecular basis of the effects of BaP on marine fish, using Mugilogobius chulae (Smith 1932) as the model. A closed colony of M. chulae was used for the BaP toxicity test. Two fish liver samples per replicate from each group were excised and blended into one sample by pooling an equal amount of liver tissue. Total RNA of all samples was extracted separately. Equal quantities of total RNA from the three replicates of the two groups were pooled for sequencing. The sequencing cDNA libraries were sequenced using Illumina HiSeq 2000 system. Differentially expressed genes were detected with the DEGSeq R package. In total, 52,364,032 and 53,771,748 clean nucleotide reads were obtained in the control and BaP-exposed libraries, respectively, with N50 lengths of 1277 and 1288 bp, respectively. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses revealed a significant enrichment of genes related to detoxification, transportation, and lipid metabolism. We also identified, for the first time, an association between endoplasmic reticulum dysfunction and lipid metabolism resulting from BaP exposure. Using quantitative real-time PCR, some effective molecular biomarkers for monitoring of BaP-polluted seawater were identified. The results demonstrate that BaP enhanced the expression of genes involved in detoxification in M. chulae and inhibited that of genes related to lipid metabolism, possibly by suppressing the expression of numerous ER-related genes involved in fat digestion and absorption.
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Eco-efficiency Analysis of Urban Agglomeration in the Middle Reaches of the Yangtze River
Minghui Chen,Jianjun Miao 한국유통과학회 2019 The Journal of Industrial Distribution & Business( Vol.10 No.1
Purpose - Urban agglomeration construction is one of national strategic plans to accelerate the development of industrialization and urbanization in China, which has threatened the eco-environmental quality at the same time. This paper selected the urban agglomeration in the middle reaches of the Yangtze River as the research area. Research design, data, and methodology - The the slack-based measurement (SBM) model considering undesirable outputs is applied to measure the eco-efficiency of this urban agglomerations during 2006-2015. Results - The empirical results show that average eco-efficiency of the urban agglomeration in the middle reaches of the Yangtze River is 0.595. Regional ecological development is unbalanced. The highest eco-efficiency is recorded at Wuhan Metropolitan Area, and the lowest one is at the Changsha-Zhuzhou-Xiangtan City Group. Energy consumption and waste dust emissions are the key factors led to ecological inefficiency. Based on this, potentials for energy saving and waste dust reducing are calculated. Conclusions - Finally, this study provides policy implications targeted to promote the coordinating development of economy and eco-environment under the construction of urban agglomeration.
ScienceON
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